Complete NMR signal assignments of flavonol derivatives

2006 ◽  
Vol 44 (2) ◽  
pp. 188-190 ◽  
Author(s):  
Hojung Kim ◽  
Byoung-Ho Moon ◽  
Joong-Hoon Ahn ◽  
Yoongho Lim
Keyword(s):  
Flavonol Derivatives

scholarly journals Dihydroflavonol and Flavonol Derivatives from Macaranga Recurvata

2012 ◽  
Vol 7 (10) ◽  
pp. 1934578X1200701
Author(s):  
Mulyadi Tanjung ◽  
Euis H. Hakim ◽  
Elfahmi ◽  
Jalifah Latip ◽  
Yana M. Syah
Keyword(s):  
Strong Activity ◽  
Spectroscopic Evidence ◽  
New Compounds ◽  
Flavonol Derivatives

Two new dihydroflavonol derivatives, macarecurvatins A and B, have been isolated from the leaves of Macaranga recurvata(Euphorbiaceaae), along with the known compounds diisoprenylaromadendrin, glyasperin A and broussoflavonol F. The structures of the new compounds were determined on the basis of spectroscopic evidence. Upon cytotoxic evaluation against P-388 cells, macarecurvatin B showed strong activity with an IC50 of 0.83 μM.

scholarly journals Hepatoprotective Effects of Standardized Extracts from an Ancient Italian Apple Variety (Mela Rosa dei Monti Sibillini) against Carbon Tetrachloride (CCl4)-Induced Hepatotoxicity in Rats

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1816 ◽  
Author(s):  
Hasan Yousefi-Manesh ◽  
Ahmad Reza Dehpour ◽  
Sedighe Ansari-Nasab ◽  
Sara Hemmati ◽  
Mohammad Amin Sadeghi ◽  
...  
Keyword(s):  
Day Treatment ◽  
Central Italy ◽  
Serum Levels ◽  
Liquid Chromatography Mass Spectrometry ◽  
Apple Variety ◽  
Tnf Α ◽  
Hematoxylin And Eosin ◽  
Factor Α ◽  
Flavonol Derivatives ◽  
Necrosis Factor

The aim of this research was to examine the effect of the hydroalcoholic extracts from the peel (APE) and pulp (APP) of a traditional apple cultivar from central Italy (Mela Rosa dei Monti Sibillini) on CCl4-induced hepatotoxicity in rats. Phytoconstituents were determined by liquid chromatography–mass spectrometry (LC-MS) analysis showing an abundance of proanthocyanidins and flavonol derivatives together with the presence of annurcoic acid in APE. Wistar rats received APE/APP (30 mg/kg oral administration) for three days before CCl4 injection (2 mL/kg intraperitoneal once on the third day). Treatment with both APE and APP prior to CCl4 injection significantly decreased the serum levels of aspartate aminotransferase (AST), alkaline phosphatase (ALP) and alanine aminotransferase (ALT) compared to the CCl4 group. Besides, pretreatment with APE reversed the CCl4 effects on superoxide dismutase (SOD), myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α) and interleukin-1beta (IL-1β) levels in liver tissue in rats and reduced tissue damage as shown in hematoxylin and eosin staining. These results showed that this ancient Italian apple is worthy of use in nutraceuticals and dietary supplements to prevent and/or protect against liver disorders.

scholarly journals Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs

2016 ◽  
Vol 59 (16) ◽  
pp. 7598-7616 ◽  
Author(s):  
Chiara Borsari ◽  
Rosaria Luciani ◽  
Cecilia Pozzi ◽  
Ina Poehner ◽  
Stefan Henrich ◽  
...  
Keyword(s):  
Flavonol Derivatives

scholarly journals Flavonoids from Milletia leucantha and Their Cytotoxicity

2018 ◽  
Vol 13 (8) ◽  
pp. 1934578X1801300
Author(s):  
Uraiwan Sriphana ◽  
Chavi Yenjai ◽  
Siriporn Tungnoi ◽  
Jongjai Srirapa ◽  
Auemporn Junsongduang
Keyword(s):  
Cytotoxic Activity ◽  
Vero Cell ◽  
Cell Line ◽  
Vero Cells ◽  
2D Nmr ◽  
Nmr Techniques ◽  
Vero Cell Lines ◽  
First Time ◽  
Flavonol Derivatives ◽  
Mcf 7

Two known chalcones (1–2), five known flavonol derivatives (3 and 5–8) and one flavone (4) were isolated for the first time from fruits of Millettia leucantha Kurz. In addition, 5 was found for the first time from this genus. Their structures were elucidated on the basis of IR, MS, 1D and 2D NMR techniques. Chalcone 1 exhibited moderate cytotoxicity against the MCF-7 cell line with an IC50 value of 50.93 μM, whereas this compound showed inactive cytotoxicity against Vero cells. Compound 2 exhibited cytotoxicity against the KB, NCI-H187 and Vero cell lines with IC50 values of 63.64, 114.44 and 28.44 μM, respectively. Compound 8 only showed cytotoxic activity against the KB cell line with an IC50 value of 110.23 μM.

ChemInform Abstract: Synthesis of Flavonol Derivatives as Probes of Biological Processes.

ChemInform ◽  
2001 ◽  
Vol 32 (10) ◽  
pp. no-no
Author(s):  
Hiroko Tanaka ◽  
Michelle M. Stohlmeyer ◽  
Thomas J. Wandless ◽  
Loverine P. Taylor
Keyword(s):  
Biological Processes ◽  
Flavonol Derivatives

Flavonol Derivatives for Determination of Cr(III) and W(VI)

2000 ◽  
Vol 135 (1-2) ◽  
pp. 19-27 ◽  
Author(s):  
Abdel-Aziz Youssef El-Sayed ◽  
Ebtesam Ahmad Saad ◽  
Basheer Mohamed Mohamed Ibrahime ◽  
Mohamed Tarek Mohamed Zaki
Keyword(s):  
Flavonol Derivatives

scholarly journals Photoacidity as a tool to rationalize excited state intramolecular proton transfer reactivity in flavonols

2018 ◽  
Vol 17 (2) ◽  
pp. 231-238 ◽  
Author(s):  
Luís Gustavo Teixeira Alves Duarte ◽  
José Carlos Germino ◽  
Cláudia de Ávila Braga ◽  
Cristina Aparecida Barboza ◽  
Teresa Dib Zambon Atvars ◽  
...  
Keyword(s):  
Excited State ◽  
Proton Transfer ◽  
Excited States ◽  
Intramolecular Proton Transfer ◽  
Flavonol Derivatives ◽  
Proton Transfer Reactivity ◽  
Electronic Ground

Determination of acidic strengths at the electronic ground and excited states of flavonol derivatives.

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