scholarly journals Endorsement frequencies and factor structure of DSM-III-R and DSM-IV Generalized Anxiety Disorder symptoms in women: implications for future research, classification, clinical practice and comorbidity

2005 ◽  
Vol 14 (2) ◽  
pp. 69-81 ◽  
Author(s):  
Thomas S. Kubarych ◽  
Steven H. Aggen ◽  
John M. Hettema ◽  
Kenneth S. Kendler ◽  
Michael C. Neale
Assessment ◽  
2008 ◽  
Vol 15 (3) ◽  
pp. 343-350 ◽  
Author(s):  
Thomas L. Rodebaugh ◽  
Robert M. Holaway ◽  
Richard G. Heimberg

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Michael S. Scheeringa ◽  
Lauren C. Burns

Generalized anxiety disorder (GAD) is purported to start in early childhood but concerns about attenuation of anxiety symptoms over time and the development of emerging cognitive and emotional processing capabilities pose multiple challenges for accurate detection. This paper presents the first known case reports of very young children with GAD to examine these developmental challenges at the item level. Three children, five-to-six years of age, were assessed with the Diagnostic Infant and Preschool Assessment twice in a test-retest reliability study. One case appeared to show attenuation of the worries during the test-retest period based on caregiver report but not when followed over two years. The other two cases showed stability of the full complement of diagnostic criteria. The cases were useful for demonstrating that the current diagnostic criteria appear adequate for this developmental period. The challenges of accurate assessment of young children that might cause missed diagnoses are discussed. Future research on the underlying dysregulation of negative emotionality and long-term follow-ups are needed to better understand the etiology, treatment, and course of GAD in this age group.


2011 ◽  
Vol 3 ◽  
pp. CMPsy.S5069 ◽  
Author(s):  
Mark J. Boschen

Generalized anxiety disorder (GAD) is a chronic illness which impacts significantly on an individual's functioning and quality of life. Pregabalin is a novel structural analogue of the inhibitory neurotransmitter GABA, acting to reduce calcium ion flow through the α2δ subunit of pre-synaptic voltage-dependent calcium channels. Pregabalin has been used in treatment of GAD in a total of eight published controlled trials. In each trial, pregabalin has demonstrated a superiority over placebo, with response rates of over 40% in all studies, including patients on lower doses. One study has provided preliminary evidence for the efficacy of pregabalin in treatment of GAD in older adults. Pregabalin is generally well tolerated, with the most common adverse events being dizziness and somnolence. Adverse effects are generally mild-to-moderate, and transient. Pregabalin has low abuse potential. Limitations of the current literature are discussed, and directions for future research are proposed.


2002 ◽  
Vol 43 (7) ◽  
pp. 959-967 ◽  
Author(s):  
Armando A. Pina ◽  
Wendy K. Silverman ◽  
Candice A. Alfano ◽  
Lissette M. Saavedra

2005 ◽  
Vol 20 (3) ◽  
pp. 229-235 ◽  
Author(s):  
Marc Ansseau ◽  
Benjamin Fischler ◽  
Michel Dierick ◽  
Annick Mignon ◽  
Sophie Leyman

AbstractPurposeGADIS aims at determining the prevalence of generalized anxiety disorder (GAD) and major depression (MD) in primary care and their impact on the patient’s functioning in Belgium and Luxemburg.MethodsA large scale screening program was conducted at the consultation of general practitioners to detect patients with GAD and MD according to DSM-IV criteria. We collected additional data regarding the use of hypnotic, tranquilizer, antidepressant and analgesic medications. Impact on the patient was assessed with the Sheehan disability scale.ResultsThree hundred GP’s in Belgium and Luxemburg were asked to screen 50 consecutive patients. Of the 13,677 analyzed patients, 8.3% were diagnosed to have GAD and 6.3% MD. Comorbidity was observed in 4.2% of patients. The prevalence was much higher in the French-speaking part of Belgium. GAD and MD were associated with impairment in social, familial and professional functioning. Only a minority of patients with GAD and/or MD was treated with an antidepressant and almost half of subjects with GAD and/or MD were treated with a tranquilizer.ConclusionsPrevalence rates of GAD and MD in primary care in Belgium are comparable to other countries. GAD and MD are disabling conditions. Antidepressants are still used only in a minority of subjects with GAD and/or MD in primary care in Belgium and Luxemburg. The prevalence of GAD and MD appears to be much higher in French-speaking parts of Belgium.


2012 ◽  
Vol 20 (11) ◽  
pp. 963-972 ◽  
Author(s):  
Johan Nilsson ◽  
Svante Östling ◽  
Margda Waern ◽  
Björn Karlsson ◽  
Robert Sigström ◽  
...  

2002 ◽  
Vol 32 (7) ◽  
pp. 1227-1237 ◽  
Author(s):  
J. HOYER ◽  
E. S. BECKER ◽  
J. MARGRAF

Background. This article presents epidemiological data on the prevalence of DSM-IV generalized anxiety disorder (GAD) and sub-threshold GAD (fulfilling three out of four GAD criteria) in young women together with data on co-morbidity and psychosocial functioning. The prevalence of clinically relevant worry and its predictive validity for the diagnosis of GAD were also examined.Method. Young women (N = 2064), aged between 18 and 25, from a representative German community sample were diagnosed with a structured clinical interview (ADIS-L, German research version). An additional interview questioned all the participants about the frequency/intensity and uncontrollability of diverse worry topics.Results. Thirty-seven participants (1.8%) fulfilled the criteria of current GAD (1 week point prevalence) and 56 received a lifetime diagnosis (2.7%); a further 50 participants (2.3%) were diagnosed with sub-threshold GAD. Co-morbidity between GAD and other disorders was high for current (68%) and lifetime GAD (91%). GAD, as well as sub-threshold GAD, showed clearly reduced levels of psychosocial functioning. Whereas worries of low intensity and high controllability were ubiquitous in all subsamples, clinically defined worrying was rarely present in healthy subjects (0.89%) and of adequate predictive accuracy for GAD.Conclusions. Full GAD and sub-threshold GAD were moderately frequent in young women. Although DSM-IV worry criteria proved to be highly useful, the strictness of the complete GAD-criteria should not lead to absence of attention from subclinical generalized anxiety states in research and practice.


2019 ◽  
Vol 10 (2) ◽  
pp. 204380871984152 ◽  
Author(s):  
Melina M. Ovanessian ◽  
Naomi Koerner ◽  
Martin M. Antony ◽  
Michel J. Dugas

This experiment tested a novel written exposure intervention for generalized anxiety disorder (GAD) that consisted of guided rescripting of participants’ worst fear. After describing their worst fear, adults with GAD ( N = 79) were randomly assigned to one of three writing interventions, each consisting of three sessions on consecutive days: (1) standard written exposure (WE), (2) written exposure with rescripting (RWE), and (3) neutral control writing (NC). Measures of symptoms and worry-associated processes were administered at pre- and post-intervention, and at 1-week and 1-month follow-ups. Worry declined significantly in all three conditions. Participants in WE reported significant reductions in fear of anxiety, whereas those in RWE reported significant reductions in fear of anger. Participants in RWE and NC reported a significant decrease in fear of positive emotion. Following RWE, participants perceived their feared scenario as less costly and perceived themselves as better able to cope with it, whereas participants in the WE and NC did not show these changes. Cognitive avoidance, intolerance of uncertainty, and negative problem orientation did not change. Findings suggest overall, RWE was not superior to WE, and that more research is needed to assess their therapeutic potential. Strengths and limitations are discussed for the benefit of future research on exposure for GAD.


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