Long-term sequelae after pediatric brain tumors: Their effect on disability and quality of life

1990 ◽  
Vol 18 (4) ◽  
pp. 304-310 ◽  
Author(s):  
Birgitta Lannering ◽  
Ildiko Marky ◽  
Anita Lundberg ◽  
Elisabeth Olsson
Keyword(s):  
Quality Of Life ◽  
Brain Tumors ◽  
Pediatric Brain Tumors ◽  
Pediatric Brain

Impact of Late Effects on Health-Related Quality of Life in Survivors of Pediatric Brain Tumors

2014 ◽  
Vol 37 (6) ◽  
pp. E1-E14 ◽  
Author(s):  
Iori Sato ◽  
Akiko Higuchi ◽  
Takaaki Yanagisawa ◽  
Shiho Murayama ◽  
Toshihiro Kumabe ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Brain Tumors ◽  
Late Effects ◽  
Pediatric Brain Tumors ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Pediatric Brain

One-year Quality of Life Results After Proton Irradiation for Pediatric Brain Tumors

2012 ◽  
Vol 84 (3) ◽  
pp. S634-S635
Author(s):  
R.B. Marcus ◽  
D.J. Indelicato ◽  
C.G. Morris ◽  
R.L. Rotondo ◽  
P. Aldana ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Brain Tumors ◽  
Proton Irradiation ◽  
Pediatric Brain Tumors ◽  
One Year ◽  
Pediatric Brain

Determinants of quality of life outcomes for survivors of pediatric brain tumors

2017 ◽  
Vol 64 (9) ◽  
pp. e26481 ◽  
Author(s):  
Maru Barrera ◽  
Eshetu G. Atenafu ◽  
Fiona Schulte ◽  
Ute Bartels ◽  
Lillian Sung ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Brain Tumors ◽  
Pediatric Brain Tumors ◽  
Life Outcomes ◽  
Quality Of Life Outcomes ◽  
Pediatric Brain

scholarly journals Incidence, risk factors, and longitudinal outcome of seizures in long-term survivors of pediatric brain tumors

Epilepsia ◽  
2015 ◽  
Vol 56 (10) ◽  
pp. 1599-1604 ◽  
Author(s):  
Nicole J. Ullrich ◽  
Scott L. Pomeroy ◽  
Kush Kapur ◽  
Peter E. Manley ◽  
Liliana C. Goumnerova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Brain Tumors ◽  
Pediatric Brain Tumors ◽  
Longitudinal Outcome ◽  
Incidence Risk ◽  
Long Term Survivors ◽  
Pediatric Brain

scholarly journals Epilepsy surgery related to pediatric brain tumors: Miami Children’s Hospital experience

2015 ◽  
Vol 16 (6) ◽  
pp. 675-680 ◽  
Author(s):  
Aria Fallah ◽  
Alexander G. Weil ◽  
Samir Sur ◽  
Ian Miller ◽  
Prasanna Jayakar ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Brain Tumors ◽  
Epilepsy Surgery ◽  
Pediatric Patients ◽  
Pediatric Brain Tumors ◽  
Seizure Freedom ◽  
Seizure Recurrence ◽  
Children's Hospital ◽  
Pediatric Brain

OBJECT Pediatric brain tumors may be associated with medically intractable epilepsy for which surgery is indicated. The authors sought to evaluate the efficacy of epilepsy surgery for seizure control in pediatric patients with brain tumors. METHODS The authors performed a retrospective review of consecutive patients undergoing resective epilepsy surgery related to pediatric brain tumors at Miami Children’s Hospital between June 1986 and June 2014. Time-to-event analysis for seizure recurrence was performed; an “event” was defined as any seizures that occurred following resective epilepsy surgery, not including seizures and auras in the 1st postoperative week. The authors analyzed several preoperative variables to determine their suitability to predict seizure recurrence following surgery. RESULTS Eighty-four patients (47 males) with a mean age (± standard deviation) of 8.7 ± 5.5 years (range 0.5–21.6 years) were included. The study included 39 (46%) patients with gliomas, 20 (24%) with dysembryoplastic neuroepithelial tumors (DNETs), 14 (17%) with gangliogliomas, and 11 (13%) with other etiologies. Among the patients with gliomas, 18 were classified with low-grade glioma, 5 had oligodendroglioma, 6 had uncategorized astrocytoma, 3 had pilocytic astrocytoma, 3 had pleomorphic xanthoastrocytoma, 3 had glioblastoma, and 1 had gliomatosis cerebri. Seventy-nine (94.0%) resections were guided by intraoperative electrocorticography (ECoG). The mean time (± standard deviation) to seizure recurrence was 81.8 ± 6.3 months. Engel Class I outcome was achieved in 66 (78%) and 63 (75%) patients at 1 and 2 years’ follow-up, respectively. Patients with ganglioglioma demonstrated the highest probability of long-term seizure freedom, followed by patients with DNETs and gliomas. In univariate analyses, temporal location (HR 1.75, 95% CI 0.26–1.27, p = 0.171) and completeness of resection (HR 1.69, 95% CI 0.77–3.74, p = 0.191) demonstrated a trend toward a longer duration of seizure freedom. CONCLUSIONS ECoG-guided epilepsy surgery for pediatric patients with brain tumors is highly effective. Tumors located in the temporal lobe and those in which a complete ECoG-guided resection is performed may result in a greater likelihood of long-term seizure freedom.

Tumor location and neurocognitive impairment in adult survivors of pediatric brain tumors: A report from the St. Jude Lifetime Cohort (SJLIFE).

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 9531-9531
Author(s):  
Tara M. Brinkman ◽  
Wei Liu ◽  
Gregory T. Armstrong ◽  
Amar J. Gajjar ◽  
Thomas E. Merchant ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Processing Speed ◽  
Adult Survivors ◽  
Pediatric Brain Tumors ◽  
Tumor Location ◽  
Age At Diagnosis ◽  
Neurocognitive Functions ◽  
Pediatric Brain

9531 Background: Follow-up guidelines identify supratentorial tumor location as a risk factor for poor neurocognitive outcomes during childhood; yet few studies have systematically compared long-term cognitive outcomes between adult survivors of childhood infratentorial and supratentorial brain tumors. Methods: Neurocognitive functions were evaluated in 130 adult survivors of pediatric brain tumors (58 supratentorial and 72 infratentorial, mean [SD] current age = 27.4 years [5.2], age at diagnosis = 8.6 years [4.6], and time since diagnosis = 18.8 years [4.8]) participating in the SJLIFE long-term follow-up protocol. Age-adjusted standard scores for measures of intelligence, attention, memory, processing speed, and executive functioning were calculated, with clinical impairment defined as scores <10th percentile. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable logistic regression models to examine associations between neurocognitive functions and tumor location. Results: As a group, survivors performed below average across multiple neurocognitive domains, including full scale IQ (mean=88.1; SD=18.2), with 34% demonstrating impaired IQ. Survivors of infratentorial tumors were more likely to be impaired on measures of focused attention (OR=2.19, 95% CI=1.03-4.65) and fine motor dexterity (OR=2.62, 95% CI=1.21-5.66) compared to survivors of supratentorial tumors. After adjusting for sex, age at diagnosis, shunt placement and cranial radiation (yes/no), infratentorial tumor location was only associated with reduced performance on a task of visual abstract reasoning (OR=3.76, 95% CI=1.40-10.1). Cranial radiation therapy was independently associated with impaired short-term memory (OR=15.6, 95% CI=1.64-147.8) and processing speed (OR=3.86, 95% CI=1.15-13.0). Conclusions: Tumor location was not associated with neurocognitive impairment after adjusting for treatment exposures. To further delineate potential differences associated with tumor location, future studies will examine factors including radiation dose/volume, extent of surgical resection, and medical complications.

Management and Surveillance of Short- and Long-Term Sequelae of Radiation Therapy for the Treatment of Pediatric Brain Tumors

2020 ◽  
Vol 18 (06) ◽  
pp. 307-312
Author(s):  
Fred Chiu-Lai Lam ◽  
Ekkehard M Kasper ◽  
Anand Mahadevan
Keyword(s):  
Radiation Therapy ◽  
Brain Tumors ◽  
Pediatric Brain Tumors ◽  
Special Edition ◽  
Long Term Effects ◽  
Transition Into Adulthood ◽  
Short And Long Term ◽  
Pediatric Brain

AbstractRadiation therapy (RT) is a mainstay for the treatment of pediatric brain tumors. As improvements in and sophistication of this modality continue to increase the survival of patients, the long-term sequelae of RT pose significant challenges in the clinical management of this patient population as they transition into adulthood. In this special edition, we review the short- and long-term effects of RT for the treatment of pediatric brain tumors and the necessary surveillance required for follow-up.

Health-related Quality of Life in Long-term Survivors of Brain Tumors in Childhood and Adolescence

2015 ◽  
Vol 37 (5) ◽  
pp. 362-367 ◽  
Author(s):  
JoAnn Duckworth ◽  
Trishana Nayiager ◽  
Eleanor Pullenayegum ◽  
Anthony Whitton ◽  
Robert Hollenberg ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Brain Tumors ◽  
Childhood And Adolescence ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Long Term Survivors
Sign in / Sign up

Export Citation Format

Share Document