The staging of childhood acute lymphoblastic leukemia: Strategies of the childrens cancer study group and a three-dimensional technic of multivariate analysis

1986 ◽  
Vol 14 (5) ◽  
pp. 271-280 ◽  
Author(s):  
W. Archie Bleyer ◽  
Harland Sather ◽  
Peter Coccia ◽  
John Lukens ◽  
Stuart Siegel ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Three Dimensional ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Study Group ◽  
Cancer Study ◽  
Cancer Study Group

Effects of radiation on ovarian function in long-term survivors of childhood acute lymphoblastic leukemia: a report from the Childrens Cancer Study Group.

1987 ◽  
Vol 5 (11) ◽  
pp. 1759-1765 ◽  
Author(s):  
M R Hamre ◽  
L L Robison ◽  
M E Nesbit ◽  
H N Sather ◽  
A T Meadows ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Ovarian Function ◽  
Lymphoblastic Leukemia ◽  
Pubertal Development ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Study Group ◽  
Cancer Study ◽  
Cancer Study Group ◽  
Sexual Characteristics

The Childrens Cancer Study Group has assessed serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and pubertal development in 97 long-term female survivors of childhood acute lymphoblastic leukemia (ALL). All patients received identical induction and maintenance therapy with either 18 or 24 Gy of radiation therapy (RT) to one of the following fields: cranial, craniospinal, or craniospinal plus 12 Gy abdominal RT including the ovaries. Thirty-six percent (35 patients) were found to have above normal levels of FSH and/or LH. The percentages of elevated values for RT fields were 93% for craniospinal plus abdominal RT, 49% for craniospinal RT, and 9% for cranial RT (P less than .001). A dose-response relationship was observed between 18 Gy and 24 Gy in females receiving only craniospinal RT (P = .01). Craniospinal plus abdominal RT and abnormal FSH/LH levels were significantly associated with lack of pubertal development and delayed onset of menses. Duration of maintenance chemotherapy was not associated with abnormal gonadotropin levels or the development of secondary sexual characteristics. Additional follow-up of this cohort is needed to establish the ultimate pubertal development and fertility of these patients.

Sign in / Sign up

Export Citation Format

Share Document