Vincristine and prednisone vs vincristine, l-asparaginase, and prednisone for second remission induction of acute lymphocytic leukemia in children

1979 ◽  
Vol 6 (4) ◽  
pp. 317-323 ◽  
Author(s):  
Jay Herson ◽  
Kenneth A. Starling ◽  
Paul G. Dyment ◽  
G. Bennett Humphrey ◽  
Jeanette Pullen ◽  
...  
Keyword(s):  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Remission Induction ◽  
Leukemia In Children

scholarly journals Intensive chemotherapy with mitoxantrone and high-dose cytosine arabinoside followed by granulocyte-macrophage colony-stimulating factor in the treatment of patients with acute lymphocytic leukemia

Blood ◽  
1992 ◽  
Vol 79 (4) ◽  
pp. 876-881 ◽  
Author(s):  
HM Kantarjian ◽  
EH Estey ◽  
S O'Brien ◽  
E Anaissie ◽  
M Beran ◽  
...  
Keyword(s):  
Acute Lymphocytic Leukemia ◽  
Complete Response ◽  
Lymphocytic Leukemia ◽  
Remission Induction ◽  
Intensive Chemotherapy ◽  
Colony Stimulating Factor ◽  
Gm Csf ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

Abstract Thirty-four adults with refractory acute lymphocytic leukemia received salvage therapy with mitoxantrone 5 mg/m2 intravenously over 1 hour daily for 5 days and cytosine arabinoside (ara-C) 3 g/m2 intravenously over 2 hours every 12 hours for six doses, followed by granulocyte- macrophage colony-stimulating factor (GM-CSF) 125 microgram/m2 intravenously over 4 hours daily until recovery of granulocytes above 2.0 x 10(3)/microL. Their outcome was compared with 29 prognostically similar historical control patients treated with the identical chemotherapy without GM-CSF. Overall, the complete response rates were similar in the treatment and control groups (13 of 34 [38%] v 11 of 29 [38%]). There was a trend for less remission induction mortality in the GM-CSF-treated patients (2 of 34 [6%] v 6 of 29 [21%]; P = .08), but, conversely, a higher rate of resistant disease (19 of 34 [56%] v 10 of 29 [34%]; P = .09). Recovery of granulocyte counts above 500/microL was significantly faster in the GM-CSF-treated group (25 days v 33 days; P less than .01), but there was no reduction in the incidence of febrile episodes (91% v 93%) or of documented infections (59% v 59%). Survival was prolonged in the GM-CSF-treated patients but was not of clinical relevance (31 v 20 weeks; P = .05). In summary, the addition of GM-CSF to intensive chemotherapy in refractory adult ALL was associated with a reduction in the remission induction mortality, probably secondary to a shorter duration of granulocytopenia, but not with an improvement in complete response rates.

Systemic Exposure to Mercaptopurine as a Prognostic Factor in Acute Lymphocytic Leukemia in Children

1990 ◽  
Vol 323 (1) ◽  
pp. 17-21 ◽  
Author(s):  
Gideon Koren ◽  
Gianmario Ferrazini ◽  
Hassan Sulh ◽  
Anne Marie Langevin ◽  
Joseph Kapelushnik ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Acute Lymphocytic Leukemia ◽  
Systemic Exposure ◽  
Lymphocytic Leukemia ◽  
Leukemia In Children

Early results of intensified remission induction chemotherapy for childhood acute lymphocytic leukemia

1986 ◽  
Vol 14 (3) ◽  
pp. 177-181 ◽  
Author(s):  
Gaston K. Rivera ◽  
Stephen L. George ◽  
Dorothy Williams ◽  
A. Thomas Look ◽  
Minnie Abromowitch ◽  
...  
Keyword(s):  
Induction Chemotherapy ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Remission Induction ◽  
Early Results

Acute lymphocytic leukemia in children

Cancer ◽  
1975 ◽  
Vol 36 (S2) ◽  
pp. 770-774 ◽  
Author(s):  
Joseph V. Simone ◽  
Rhomes J. A. Aur ◽  
H. Omar Hustu ◽  
Manuel Verzosa
Keyword(s):  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Leukemia In Children

scholarly journals TS Gene Polymorphisms Correlate with Susceptibility to Acute Lymphocytic Leukemia in Children

2017 ◽  
Vol 23 ◽  
pp. 3095-3104 ◽  
Author(s):  
Runyin Zou ◽  
Xiangling He ◽  
Yanpeng Wu ◽  
Xin Tian ◽  
Yalan You ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Leukemia In Children
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