Pre-eruptive varicella zoster virus encephalitis in two children after haematopoietic stem cell transplantation

2002 ◽  
Vol 38 (4) ◽  
pp. 288-289 ◽  
Author(s):  
Tobias Tenenbaum ◽  
Christof Maria Kramm ◽  
Hans-Jürgen Laws ◽  
Wenzel Nürnberger ◽  
Hans-Gerd Lenard ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Varicella Zoster Virus ◽  
Cell Transplantation ◽  
Haematopoietic Stem Cell Transplantation ◽  
Haematopoietic Stem Cell ◽  
Virus Encephalitis ◽  
Varicella Zoster

Dynamics in children and adolescents who experience varicella zoster virus infections after haematopoietic stem cell transplantation: a case-control study

2011 ◽  
Vol 139 (11) ◽  
pp. 1701-1709 ◽  
Author(s):  
S. AYTAÇ ◽  
S. S. YALÇIN ◽  
Ö. KÜÇÜKBAYRAK ◽  
M. ÇETİN ◽  
D. UÇKAN
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Varicella Zoster Virus ◽  
Haematopoietic Stem Cell Transplantation ◽  
Case Control Study ◽  
Case Control ◽  
Haematopoietic Stem Cell ◽  
Control Group ◽  
Varicella Zoster ◽  
Control Study

SUMMARYWe evaluated the incidence of varicella-zoster virus (VZV) infections, including herpes zoster (HZ), and investigated the associated risk factors for HZ and compared lymphocyte subsets of these patients at 1, 3 and 6 months following haematopoietic stem cell transplantation (HSCT) in a case-control study in children and adolescents. The incidence of HZ infection at the first year after HSCT was 17/125 (13·6%). The cumulative incidence of HZ infection was 22/125 (17·6%). Sixteen (73%) cases with HZ and 11 (32%) cases in the control group had a diagnosis of malignant disorder. No significant difference was noted between the HZ group and the control group in absolute lymphocyte number and subsets (except WBC) at the pre-transplant evaluation. Pre-transplant WBC count was statistically lower in the HZ group (P<0·05). The CD4/CD8 ratios were lower in the HZ group during the first 6 months after HSCT, and the decrease was statistically significant at 6 months compared to the control group. In conclusion, patients undergoing HSCT for a malignant disorder had a significantly higher risk of VZV infection than those with non-malignant disorders and pretransplant donor characteristics were not helpful in predicting risk of post-transplant VZV infection.

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