Successful umbilical cord blood transplantation in an infant with ALL failing initial autologous peripheral blood stem cell transplantation

2001 ◽  
Vol 38 (1) ◽  
pp. 60-61
Author(s):  
Tatsuo Shimokawa ◽  
Hiromi Ohashi ◽  
Yoichi Takaue ◽  
Yoshifumi Kawano ◽  
Takanori Abe ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cord Blood ◽  
Umbilical Cord Blood ◽  
Peripheral Blood ◽  
Peripheral Blood Stem Cell ◽  
Cord Blood Transplantation ◽  
Umbilical Cord Blood Transplantation ◽  
Blood Transplantation ◽  
Blood Stem Cell Transplantation

scholarly journals Comparison of Umbilical Cord Blood Transplantation with Bone Marrow or Peripheral Blood Derived Stem-Cell Transplantation in Transfusion Dependent Thalassemia Patients: A Single Center Propensity Score Matching Analysis

2020 ◽  
Author(s):  
Tahereh Rostami ◽  
Amir Kasaeian ◽  
Azadeh Kiumarsi ◽  
Soroush Rad ◽  
Elham Mohammadzadeh ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Propensity Score ◽  
Stem Cell Transplantation ◽  
Umbilical Cord Blood ◽  
Peripheral Blood ◽  
Cord Blood Transplantation ◽  
Chronic Gvhd ◽  
Umbilical Cord Blood Transplantation ◽  
Blood Transplantation

Abstract Background: Successful hematopoietic stem cell transplantation (HSCT) could cure the hematological manifestations of transfusion-dependent thalassemia (TDT), but introduces risks of morbidity and mortality. Umbilical cord blood transplantation (UCBT) is considered as an acceptable strategy, by providing a condensed graft versus host disease (GvHD). This paper compares the outcomes of UCBT with HSCT from peripheral blood and bone marrow in TDT patients.Methods: Between 1998 and 2014, 10 patients with TDT underwent UCBT, which were matched with 20 patients undergone BMSCT and 20 patients undergone PBSCT, by using propensity score matching (PSM) for age, gender and thalassemia class. All patients received the same myeloablative conditioning regimen and were transplanted from a fully HLA matched sibling donor. Results: The median follow-up time after HSCT was 5.7 years. Rejection incidence was 70.0% (95% CI = 28.1%-90.4%) after UCBT, 25.6% (95% CI = 8.9%-46.4%) after BMSCT, and no rejection occurred in the PBSCT group. Acute GVHD incidence was 20.0% (95% CI = 2.6%-49.0%), 35.0% (95% CI = 15.1%-55.8%), and 40.0% (95% CI = 18.6%-60.6%) in patients undergone UCBT, BMSCT and PBSCT, respectively (P=0.62). The incidence of chronic GVHD was 7.2% (95% CI = 0.3%-28.7%), and 35.2% (95% CI = 13.7%-57.8%) in patients undergone BMSCT and PBSCT, respectively (P=0.026) and none of the patients in the UCBT group experienced chronic GvHD. Conclusions: Although the overall survival is not significantly influenced by the graft source, due to the high incidence of rejection after UCBT, the probability of thalassemia free survival is very low in these patients.

Sign in / Sign up

Export Citation Format

Share Document