The role of biopsy in the diagnosis of renal tumors of childhood: Results of the UKCCSG Wilms tumor study 3

2002 ◽  
Vol 40 (1) ◽  
pp. 18-22 ◽  
Author(s):  
Gordan M. Vujani? ◽  
Anna Kelsey ◽  
Chris Mitchell ◽  
Rosemary S. Shannon ◽  
Peter Gornall
Keyword(s):  
Wilms Tumor ◽  
Renal Tumors ◽  
Tumor Study

919: Ureteral Extension in Childhood Renal Tumors: A Report From the National Wilms Tumor Study Group (NWTSG)

2007 ◽  
Vol 177 (4S) ◽  
pp. 305-305
Author(s):  
Shane Daley ◽  
Michael Ritchey ◽  
Robert Shamberger ◽  
Robert Sawin ◽  
Thomas Hamilton ◽  
...  
Keyword(s):  
Wilms Tumor ◽  
Renal Tumors ◽  
Study Group ◽  
Tumor Study ◽  
Tumor Study Group

Ureteral extension in childhood renal tumors: a report from the national wilms tumor study group (NWTSG)

2007 ◽  
Vol 3 ◽  
pp. S40-S41
Author(s):  
Michael Ritchey ◽  
Shane Daley ◽  
Robert Shamberger ◽  
Peter Ehrlich ◽  
Gerald Haase ◽  
...  
Keyword(s):  
Wilms Tumor ◽  
Renal Tumors ◽  
Study Group ◽  
Tumor Study ◽  
Tumor Study Group

Outcome of renal tumors registered in Japan Wilms Tumor Study-2 (JWiTS-2): A report from the Japan Children's Cancer Group (JCCG)

2018 ◽  
Vol 65 (7) ◽  
pp. e27056 ◽  
Author(s):  
Tsugumichi Koshinaga ◽  
Tetsuya Takimoto ◽  
Takaharu Oue ◽  
Hajime Okita ◽  
Yukichi Tanaka ◽  
...  
Keyword(s):  
Wilms Tumor ◽  
Renal Tumors ◽  
Cancer Group ◽  
Tumor Study

Percutaneous needle biopsy preceding preoperative chemotherapy in the management of massive renal tumors in children.

1991 ◽  
Vol 9 (3) ◽  
pp. 406-415 ◽  
Author(s):  
U M Saarinen ◽  
S Wikström ◽  
O Koskimies ◽  
H Sariola
Keyword(s):  
Preoperative Chemotherapy ◽  
Needle Biopsy ◽  
Wilms Tumor ◽  
The United States ◽  
Current Approach ◽  
Renal Tumors ◽  
Tumor Study ◽  
Intratumoral Bleeding ◽  
Time Of Operation ◽  
Adequate Tissue

While the National Wilms' Tumor Study (NWTS) Group in the United States puts an emphasis on accurate staging and histology before any therapy is given for Wilms' tumor, the International Society of Pediatric Oncology (SIOP) in Europe focuses on preoperative therapy and safer surgery. Our current approach combines the benefits of both policies in the management of massive renal tumors in children. In seven consecutive patients we first obtained a percutaneous posterior needle biopsy to obtain adequate tissue for histology, and proceeded with preoperative chemotherapy with vincristine and dactinomycin until tumor shrinkage was sufficient. Tumor removals were feasible and uneventful. At the time of operation, two tumors were found to be totally or almost totally necrotic. In the others, which still included viable tumor, the histology corresponded well to the needle biopsy findings. One case with unfavorable histology and one with rhabdoid sarcoma would have been missed and given suboptimal therapy without the primary needle biopsy. As possible biopsy-related complications, subcapsular intratumoral bleeding was recognized in two patients. We conclude that percutaneous posterior needle biopsy is safe and yields definite, detailed histology in massive renal tumors in children. Preoperative chemotherapy facilitates surgery in these patients.

scholarly journals Current role of imaging in the management of children with Wilms tumor according to the new umbrella protocol

2020 ◽  
pp. 51-63
Author(s):  
Varchetta Giovanni ◽  
Tanzillo Paolina ◽  
Mei Sara
Keyword(s):  
Wilms Tumor ◽  
Abdominal Mass ◽  
Epidemiological Data ◽  
Renal Tumors ◽  
Postoperative Treatment ◽  
Malignant Rhabdoid Tumor ◽  
Presumptive Diagnosis ◽  
Medical Checkup ◽  
Abdominal Masses

Wilms tumor is the most common primary renal tumor in childhood. Children with Wilms tumor typically present with an asymptomatic abdominal mass, usually detected on a routine medical checkup or discovered coincidentally by parents. The initial differential diagnosis is with extrarenal abdominal masses; once a tumor of renal origin is established, distinguishing between Wilms tumor and other primary renal neoplasms such as congenital mesoblastic nephroma, clear cell sarcoma, malignant rhabdoid tumor and renal cell carcinoma may not be easy. However, in many cases imaging findings in conjunction with the patient's clinical and epidemiological data, allow the diagnosis of Wilms tumor. Wilms tumor care offers one of the most striking examples of success of pediatric oncology. Over the last decades the European SIOP studies have been the key to developing standardized diagnostic procedures, improved risk stratification, and adjusted treatment recommendations for children with Wilms tumor and this has resulted rate of overall survival is currently greater than 90%. As in previous SIOP trials and studies, the new protocol for the diagnosis and treatment of childhood renal tumors, the UMBRELLA SIOP–RTSG 2016, mandates preoperative chemotherapy without preceding mandatory histological assessment. Therefore, imaging studies are essential to obtain a presumptive diagnosis of WT, to provide disease staging information and to measure the tumor volume after neoadjuvant chemotherapy for the purposes of postoperative treatment stratification. This review describes role of imaging in the management of children with Wilms tumor, according to the current recommendations of the UMBRELLA protocol.

The role of surgical excision in the management of relapsed Wilms' tumor patients with pulmonary metastases: A report from the National Wilms' Tumor Study

1991 ◽  
Vol 26 (6) ◽  
pp. 728-733 ◽  
Author(s):  
Daniel M. Green ◽  
Norman E. Breslow ◽  
Yoichi li ◽  
Paul E. Grundy ◽  
Stephen J. Shochat ◽  
...  
Keyword(s):  
Pulmonary Metastases ◽  
Wilms Tumor ◽  
Surgical Excision ◽  
Tumor Patients ◽  
Tumor Study

Pathological Evaluation of Renal Tumors in Children: International Society of Pediatric Oncology Approach

1998 ◽  
Vol 1 (3) ◽  
pp. 243-248 ◽  
Author(s):  
Liliane A. Boccon-Gibod
Keyword(s):  
International Society ◽  
Pediatric Oncology ◽  
Wilms Tumor ◽  
Risk Group ◽  
Renal Tumors ◽  
Pathological Evaluation ◽  
Methods Of Treatment ◽  
New Criteria

In the majority of European countries, children with renal tumors now enter the SIOP-93-01 Trial and Study. The objective of this Study is to refine methods of treatment especialy in stage I patients. The role of institutional pathologists is important in this trial. There are new criteria for stages I and II, a new SIOP Working Classification of Renal Tumors of Childhood, and morphologic and prognostic similarities of pretreated and non-pretreated anaplastic cases. Specific problems encountered in assessing tumors treated with preoperative chemotherapy, administered to the majority of children over 6 months of age entering the SIOP Study, are discussed. The identification of a new low-risk group, the completely necrotic Wilms tumor, is outlined.

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