scholarly journals Three‐dimensional printing of patient‐specific lung phantoms for CT imaging: emulating lung tissue with accurate attenuation profiles and textures

2021 ◽  
Author(s):  
Kai Mei ◽  
Michael Geagan ◽  
Leonid Roshkovan ◽  
Harold I. Litt ◽  
Grace J. Gang ◽  
...  
Keyword(s):  
Lung Tissue ◽  
Three Dimensional ◽  
Ct Imaging ◽  
Patient Specific ◽  
Three Dimensional Printing ◽  
Attenuation Profiles ◽  
Dimensional Printing

scholarly journals Main Clinical Use of Additive Manufacturing (Three-Dimensional Printing) in Finland Restricted to the Head and Neck Area in 2016–2017

2019 ◽  
Vol 109 (2) ◽  
pp. 166-173 ◽  
Author(s):  
A.B.V. Pettersson ◽  
M. Salmi ◽  
P. Vallittu ◽  
W. Serlo ◽  
J. Tuomi ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Computer Aided Design ◽  
Three Dimensional ◽  
Patient Specific ◽  
Future Research ◽  
Imaging Data ◽  
University Hospitals ◽  
Three Dimensional Printing ◽  
Dimensional Printing ◽  
Head Area

Background and Aims: Additive manufacturing or three-dimensional printing is a novel production methodology for producing patient-specific models, medical aids, tools, and implants. However, the clinical impact of this technology is unknown. In this study, we sought to characterize the clinical adoption of medical additive manufacturing in Finland in 2016–2017. We focused on non-dental usage at university hospitals. Materials and Methods: A questionnaire containing five questions was sent by email to all operative, radiologic, and oncologic departments of all university hospitals in Finland. Respondents who reported extensive use of medical additive manufacturing were contacted with additional, personalized questions. Results: Of the 115 questionnaires sent, 58 received answers. Of the responders, 41% identified as non-users, including all general/gastrointestinal (GI) and vascular surgeons, urologists, and gynecologists; 23% identified as experimenters or previous users; and 36% identified as heavy users. Usage was concentrated around the head area by various specialties (neurosurgical, craniomaxillofacial, ear, nose and throat diseases (ENT), plastic surgery). Applications included repair of cranial vault defects and malformations, surgical oncology, trauma, and cleft palate reconstruction. Some routine usage was also reported in orthopedics. In addition to these patient-specific uses, we identified several off-the-shelf medical components that were produced by additive manufacturing, while some important patient-specific components were produced by traditional methodologies such as milling. Conclusion: During 2016–2017, medical additive manufacturing in Finland was routinely used at university hospitals for several applications in the head area. Outside of this area, usage was much less common. Future research should include all patient-specific products created by a computer-aided design/manufacture workflow from imaging data, instead of concentrating on the production methodology.

Ankylosis and pseudoankylosis of the temporomandibular joint in 10 dogs (1993–2015)

2016 ◽  
Vol 29 (05) ◽  
pp. 409-415 ◽  
Author(s):  
Peter Strøm ◽  
Boaz Arzi ◽  
Derek Cissell ◽  
Frank Verstraete
Keyword(s):  
Surgical Treatment ◽  
Range Of Motion ◽  
Temporomandibular Joint ◽  
Three Dimensional ◽  
Case Series ◽  
Patient Specific ◽  
Three Dimensional Printing ◽  
Temporomandibular Joint Ankylosis ◽  
Dimensional Printing ◽  
Joint Ankylosis

SummaryObjective: To describe the clinical features and results of treatment of true ankylosis and pseudoankylosis of the temporomandibular joint in dogs.Methods: This study was a retrospective case series. Ten client-owned dogs that were presented for inability to open the mouth or a severely decreased range of motion of the temporomandibular joint were included. Information on the surgical procedures performed and the perioperative complications were documented. Three-dimensional printing of the skull was performed in four dogs.Results: Two dogs were diagnosed with temporomandibular joint ankylosis and seven dogs with pseudoankylosis. One dog had evidence of combined temporomandibular joint ankylosis and pseudoankylosis. Of the seven dogs with pseudoankylosis, six had an osseous fusion involving the zygomatic arch and mandible. Surgical treatment was performed in nine dogs and a revision surgery was needed in one dog. Follow-up ranged from five months to eight years (mean: 48.6 months). Eight out of nine dogs that were treated surgically regained the ability to open their mouth, but six dogs never regained a fully normal temporomandibular joint range of motion.Clinical significance: Temporomandibular joint ankylosis and pseudoankylosis are uncommon in the dog. Surgical treatment for temporomandibular joint ankylosis or pseudoankylosis in dogs is a successful option and carries a prognosis dependent on patient-specific abnormalities. Computed tomography complemented with three- dimensional printing is valuable for understanding the extent of abnormalities and for preoperative planning.Supplementary material for this paper is available online at http://dx.doi.org/10.3415/VCOT-15-11-0189.

scholarly journals Three-dimensional printing of a patient-specific engineered nasal cartilage for augmentative rhinoplasty

2019 ◽  
Vol 10 ◽  
pp. 204173141882479 ◽  
Author(s):  
Hee-Gyeong Yi ◽  
Yeong-Jin Choi ◽  
Jin Woo Jung ◽  
Jinah Jang ◽  
Tae-Ha Song ◽  
...  
Keyword(s):  
Stem Cells ◽  
Computer Aided Design ◽  
Three Dimensional ◽  
Patient Specific ◽  
Adipose Derived Stem Cells ◽  
Three Dimensional Printing ◽  
Nasal Cartilage ◽  
Computer Aided ◽  
Aided Design ◽  
Dimensional Printing

Autologous cartilages or synthetic nasal implants have been utilized in augmentative rhinoplasty to reconstruct the nasal shape for therapeutic and cosmetic purposes. Autologous cartilage is considered to be an ideal graft, but has drawbacks, such as limited cartilage source, requirements of additional surgery for obtaining autologous cartilage, and donor site morbidity. In contrast, synthetic nasal implants are abundantly available but have low biocompatibility than the autologous cartilages. Moreover, the currently used nasal cartilage grafts involve additional reshaping processes, by meticulous manual carving during surgery to fit the diverse nose shape of each patient. The final shapes of the manually tailored implants are highly dependent on the surgeons’ proficiency and often result in patient dissatisfaction and even undesired separation of the implant. This study describes a new process of rhinoplasty, which integrates three-dimensional printing and tissue engineering approaches. We established a serial procedure based on computer-aided design to generate a three-dimensional model of customized nasal implant, and the model was fabricated through three-dimensional printing. An engineered nasal cartilage implant was generated by injecting cartilage-derived hydrogel containing human adipose-derived stem cells into the implant containing the octahedral interior architecture. We observed remarkable expression levels of chondrogenic markers from the human adipose-derived stem cells grown in the engineered nasal cartilage with the cartilage-derived hydrogel. In addition, the engineered nasal cartilage, which was implanted into mouse subcutaneous region, exhibited maintenance of the exquisite shape and structure, and striking formation of the cartilaginous tissues for 12 weeks. We expect that the developed process, which combines computer-aided design, three-dimensional printing, and tissue-derived hydrogel, would be beneficial in generating implants of other types of tissue.

Cardiovascular interventions planning through a three-dimensional printing patient-specific approach

2019 ◽  
Vol 20 (9) ◽  
pp. 584-596 ◽  
Author(s):  
Francesca Uccheddu ◽  
Michele Gallo ◽  
Erica Nocerino ◽  
Fabio Remondino ◽  
Miroslava Stolocova ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Patient Specific ◽  
Three Dimensional Printing ◽  
Specific Approach ◽  
Cardiovascular Interventions ◽  
Dimensional Printing

Modeling three-dimensional-printed trabecular metal structures with a homogenization approach: Application to hemipelvis reconstruction

2019 ◽  
Vol 42 (10) ◽  
pp. 575-585
Author(s):  
Luigi La Barbera ◽  
Milena Trabace ◽  
Giancarlo Pennati ◽  
José Félix Rodríguez Matas
Keyword(s):  
Asymptotic Expansion ◽  
Mechanical Response ◽  
Three Dimensional ◽  
Experimental Tests ◽  
Design Parameters ◽  
Patient Specific ◽  
Real Patient ◽  
Three Dimensional Printing ◽  
Homogenization Approach ◽  
Dimensional Printing

The application of three-dimensional printing technologies to metal materials allows us to design innovative, low-weight, patient-specific implants for orthopedic prosthesis. This is particularly true when the reconstruction of extensive metastatic bone defect is planned. Modeling complex three-dimensional-printed highly repetitive trabecular-like structures based on finite elements is computationally demanding, while homogenization algorithms offer the advantage of reduced simulation cost and time, allowing an effective evaluation of new personalized design suitable for clinical needs. This article describes and discusses the implementation of a reliable method for the multiscale modeling of trabecular structures by means of asymptotic expansion homogenization. Following the material characterization of the Ti6Al4V alloy obtained by electron beam melting technology, the asymptotic expansion homogenization was applied to two alternative low-density cell-unit designs. Model predictions demonstrated satisfactory agreement with compressive experimental tests and cantilever bending tests performed on both designs (differences lower than 5.5%). The method was extended to a real patient-specific hemipelvis reconstruction, exploiting the capability of the asymptotic expansion homogenization approach in quantitatively describing the effect of cell-unit designs and three-dimensional-printing stack direction (i.e. cell-unit orientation) both on the overall mechanical response of the implant and on the stress distribution. The hemipelvis implant filled with the higher density cell unit demonstrated to be 14% stiffer than using the lower density one, while changing the cell-unit orientation affected the stiffness up to 10%. The maximum stress values reached at the anchors were affected in a minor extent by the investigated design parameters.

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