Combining computed tomography and biologically effective dose in radiomics and deep learning improves prediction of tumor response to robotic lung stereotactic body radiation therapy

2021 ◽  
Author(s):  
Michele Avanzo ◽  
Vito Gagliardi ◽  
Joseph Stancanello ◽  
Oliver Blanck ◽  
Giovanni Pirrone ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Radiation Therapy ◽  
Deep Learning ◽  
Effective Dose ◽  
Stereotactic Body Radiation Therapy ◽  
Tumor Response ◽  
Biologically Effective Dose ◽  
Stereotactic Body Radiation

scholarly journals Clinical applicability of biologically effective dose calculation for spinal cord in fractionated spine stereotactic body radiation therapy

2015 ◽  
Vol 49 (2) ◽  
pp. 185-191 ◽  
Author(s):  
Seung Heon Lee ◽  
Kyu Chan Lee ◽  
Jinho Choi ◽  
So Hyun Ahn ◽  
Seok Ho Lee ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Radiation Therapy ◽  
Effective Dose ◽  
Stereotactic Body Radiation Therapy ◽  
Maximum Dose ◽  
Biologically Effective Dose ◽  
Stereotactic Body Radiation ◽  
Tolerance Dose ◽  
Prescription Dose ◽  
Spinal Cord Tolerance

Abstract Background. The aim of the study was to investigate whether biologically effective dose (BED) based on linearquadratic model can be used to estimate spinal cord tolerance dose in spine stereotactic body radiation therapy (SBRT) delivered in 4 or more fractions. Patients and methods. Sixty-three metastatic spinal lesions in 47 patients were retrospectively evaluated. The most frequently prescribed dose was 36 Gy in 4 fractions. In planning, we tried to limit the maximum dose to the spinal cord or cauda equina less than 50% of prescription or 45 Gy2/2. BED was calculated using maximum point dose of spinal cord. Results. Maximum spinal cord dose per fraction ranged from 2.6 to 6.0 Gy (median 4.3 Gy). Except 4 patients with 52.7, 56.4, 62.4, and 67.9 Gy2/2, equivalent total dose in 2-Gy fraction of the patients was not more than 50 Gy2/2 (12.1- 67.9, median 32.0). The ratio of maximum spinal cord dose to prescription dose increased up to 82.2% of prescription dose as epidural spinal cord compression grade increased. No patient developed grade 2 or higher radiationinduced spinal cord toxicity during follow-up period of 0.5 to 53.9 months. Conclusions. In fractionated spine SBRT, BED can be used to estimate spinal cord tolerance dose, provided that the dose per fraction to the spinal cord is moderate, e.g. < 6.0 Gy. It appears that a maximum dose of up to 45-50 Gy2/2 to the spinal cord is tolerable in 4 or more fractionation regimen.

Automated hepatobiliary toxicity prediction after liver stereotactic body radiation therapy with deep learning-based portal vein segmentation

2020 ◽  
Vol 392 ◽  
pp. 181-188 ◽  
Author(s):  
Bulat Ibragimov ◽  
Diego A.S. Toesca ◽  
Daniel T. Chang ◽  
Yixuan Yuan ◽  
Albert C. Koong ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Deep Learning ◽  
Portal Vein ◽  
Stereotactic Body Radiation Therapy ◽  
Toxicity Prediction ◽  
Stereotactic Body Radiation
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