Intrinsic radiomic expression patterns after 20 Gy demonstrate early metabolic response of oropharyngeal cancers

2021 ◽  
Author(s):  
Kyle J. Lafata ◽  
Yushi Chang ◽  
Chunhao Wang ◽  
Yvonne M. Mowery ◽  
Irina Vergalasova ◽  
...  
Keyword(s):  
Metabolic Response ◽  
Expression Patterns ◽  
Early Metabolic Response

scholarly journals Proteomic Analysis of Aortae from Human Lipoprotein(a) Transgenic Mice Shows an Early Metabolic Response Independent of Atherosclerosis

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e30383 ◽  
Author(s):  
Euan J. Rodger ◽  
Rachel J. Suetani ◽  
Gregory T. Jones ◽  
Torsten Kleffmann ◽  
Alan Carne ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Proteomic Analysis ◽  
Metabolic Response ◽  
Lipoprotein A ◽  
Early Metabolic Response

scholarly journals In vivo evaluation of tumour acidosis for assessing the early metabolic response and onset of resistance to dichloroacetate by using magnetic resonance pH imaging

2017 ◽  
Vol 51 (2) ◽  
pp. 498-506 ◽  
Author(s):  
Annasofia Anemone ◽  
Lorena Consolino ◽  
Laura Conti ◽  
Francesca Reineri ◽  
Federica Cavallo ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Metabolic Response ◽  
In Vivo Evaluation ◽  
Ph Imaging ◽  
Early Metabolic Response

PET to assess early metabolic response and to guide treatment of adenocarcinoma of the oesophagogastric junction: the MUNICON phase II trial

2007 ◽  
Vol 8 (9) ◽  
pp. 797-805 ◽  
Author(s):  
Florian Lordick ◽  
Katja Ott ◽  
Bernd-Joachim Krause ◽  
Wolfgang A Weber ◽  
Karen Becker ◽  
...  
Keyword(s):  
Phase Ii ◽  
Metabolic Response ◽  
Phase Ii Trial ◽  
Oesophagogastric Junction ◽  
Early Metabolic Response

scholarly journals Amino Acid PET Imaging of the Early Metabolic Response During Tumor-Treating Fields (TTFields) Therapy in Recurrent Glioblastoma

2018 ◽  
Vol 43 (3) ◽  
pp. 176-179 ◽  
Author(s):  
Edit Bosnyák ◽  
Geoffrey R. Barger ◽  
Sharon K. Michelhaugh ◽  
Natasha L. Robinette ◽  
Alit Amit-Yousif ◽  
...  
Keyword(s):  
Amino Acid ◽  
Pet Imaging ◽  
Metabolic Response ◽  
Recurrent Glioblastoma ◽  
Tumor Treating Fields ◽  
Amino Acid Pet ◽  
Early Metabolic Response

Early metabolic response assessment of breast cancer liver metastases: 4-week posttreatment FDG PET predicts survival after 90Y microsphere radioembolization

2019 ◽  
Vol 58 (03) ◽  
pp. 242-248 ◽  
Author(s):  
Amir Sabet ◽  
Martin Ries ◽  
Yamen Al-Khalaf ◽  
Carsten Meyer ◽  
Christian Rudlowski ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Liver Metastases ◽  
Fdg Pet ◽  
Metabolic Response ◽  
Response Assessment ◽  
Tumor Burden ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Early Metabolic Response

Abstract Aim To evaluate the feasibility of early metabolic response assessment with 18F-FDG PET/CT in patients with breast cancer liver metastases 4 weeks after radioembolization with Yttrium-90 labeled microspheres. Methods 25 patients (mean age 58y, range 40–74) with advanced stage liver metastases of breast cancer were treated with 1.9 ± 0.4 GBq of 90Y-microspheres in the salvage setting and underwent 18F-FDG PET/CT at baseline and 4 weeks post-radioembolization. 14 patients (56 %) had an excessive hepatic tumor burden (> 50 % of total liver volume), 21 patients (84 %) had extrahepatic disease. Liver lesions with the highest SUVmax were selected as target lesions and a cut-off was set at 50 % reduction to separate responders from non-responders. The predictive impact of metabolic response on overall survival (OS) was investigated along with other prognostic factors. Results The median OS in this highly advanced metastatic cohort was 7 months (95 % CI, 5–9). All patients had a reduction in SUVmax (mean ΔSUVmax: –49 ± 26 %) at 4 weeks post-treatment. Patients with > 50 % SUVmax reduction survived longer (median OS 13 mo, 95 % CI 8–18) than the remaining patients (median OS 4 mo, 95 % CI 2–6; p = 0.001). From all investigated baseline factors including age, performance status, and presence of extra-hepatic disease, only the hepatic tumor burden had a significant impact on OS (p = 0.02). Conclusions This is the first preliminary evidence in breast cancer that early post-radioembolization molecular response assessment of treated liver metastases – as early as 4 weeks posttreatment – may predict survival. If confirmed by larger series, FDG PET/CT could be considered for early response-adapted treatment modifications.

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