scholarly journals Commissioning of an ultra‐high dose rate pulsed electron beam medical LINAC for FLASH RT pre‐clinical animal experiments and future clinical human protocols

2021 ◽  
Author(s):  
Raphaël Moeckli ◽  
Patrik Gonçalves Jorge ◽  
Veljko Grilj ◽  
Roxane Oesterle ◽  
Nicolas Cherbuin ◽  
...  
Keyword(s):  
Electron Beam ◽  
Dose Rate ◽  
Animal Experiments ◽  
High Dose Rate ◽  
High Dose ◽  
Pulsed Electron Beam ◽  
Medical Linac

Dosimetric and preparation procedures for irradiating biological models with pulsed electron beam at ultra-high dose-rate

2019 ◽  
Vol 139 ◽  
pp. 34-39 ◽  
Author(s):  
Patrik Gonçalves Jorge ◽  
Maud Jaccard ◽  
Kristoffer Petersson ◽  
Maude Gondré ◽  
Maria Teresa Durán ◽  
...  
Keyword(s):  
Electron Beam ◽  
Dose Rate ◽  
High Dose Rate ◽  
High Dose ◽  
Biological Models ◽  
Pulsed Electron Beam

scholarly journals EP-1494: Absolute dosimetry with EBT3 Gafchromic films in a pulsed electron beam at high dose-rate

2016 ◽  
Vol 119 ◽  
pp. S690
Author(s):  
M. Jaccard ◽  
K. Petersson ◽  
T. Buchillier ◽  
C. Bailat ◽  
J.F. Germond ◽  
...  
Keyword(s):  
Electron Beam ◽  
Dose Rate ◽  
High Dose Rate ◽  
High Dose ◽  
Pulsed Electron Beam ◽  
Gafchromic Films

scholarly journals High-Dose-Rate Electron-Beam Dosimetry Using an Advanced Markus Chamber with Improved IonRecombination Corrections

2020 ◽  
Vol 31 (4) ◽  
pp. 145-152
Author(s):  
Dong Hyeok Jeong ◽  
Manwoo Lee ◽  
Heuijin Lim ◽  
Sang Koo Kang ◽  
Kyoung Won Jang
Keyword(s):  
Electron Beam ◽  
Dose Rate ◽  
High Dose Rate ◽  
High Dose ◽  
Beam Dosimetry

CLO19-032: Skin Cancer of the Nose: Outcome in 405 Cases Treated With Accelerated High Dose Rate Radiation Therapy

2019 ◽  
Vol 17 (3.5) ◽  
pp. CLO19-032
Author(s):  
Nicholas E. Flores ◽  
T. A. Mian ◽  
D. Liu
Keyword(s):  
Radiation Therapy ◽  
Electron Beam ◽  
Patient Satisfaction ◽  
Skin Cancer ◽  
Dose Rate ◽  
Response Rates ◽  
High Dose Rate ◽  
High Dose ◽  
Bulky Disease ◽  
Electronic Brachytherapy

Overview: Between 2013 and 2016, we treated 1,500 cases of nonmelanoma skin cancer using high-dose radiation therapy. In this series, 405 cases involved the nose. Patient selection was limited to age >35 years, tumor size <40 mm in diameter and <5 mm thick. Demographics included 86.7% basal, 12.8% squamous, 1 lymphoma, 1 melanoma. Size by treatment field: 66.9% 10mm, 28.1% 20mm, 4.7% 35mm, and <1% 50mm. Age: 76.8 years median (37.3–99.7 years) Methods: Radiation therapy was administered following guidelines suggested by ASTRO and AAPM using either a 6MeV LINAC electron beam or 50kV x-ray source. The majority of patients received 4,000 cGy in 500 cGy fractions given twice weekly. Prescribed treatment depth was zero (0) mm for non-bulky disease. Bolus was used for all electron treatments. Wax-coated nasal shields were used for lateralized or large midline lesions. Devitalized tumor was debrided and/or treatment depth modified during treatment as needed. Treatment interruptions were rare, usually due to infection, and limited to less than 2 weeks. Results: 99% of patients maintained a complete response at 2 years (0.2–3.7 years) median follow-up, with 1 edge-of-field progression and 1 in-field recurrence. Side effects seen included transient nasal mucositis (10%) limited to lateralized or large midline lesions, superficial infection (<1%) limited to patients with a history of moderate to severe acne and/or patients applying cosmetic concealers during treatment. No chronic nasal dryness, cartilage necrosis, ophthalmic injury, nasolacrimal disruption, or dental complications occurred. Patient satisfaction/cosmesis: patient-scored functional and cosmetic outcomes ranged from very good to excellent in 100% of patients. Conclusion: Accelerated high dose rate radiation therapy using either LINAC electron beam or electronic brachytherapy is an effective and well-tolerated treatment option for carefully selected patients with basal and squamous cell skin cancer of the nose. Response rates for electron beam or low-energy x-rays with this dose schedule were similar. When compared to surgery, radiation therapy results in high patient satisfaction and excellent cosmesis without the need for lengthy postoperative care or reconstruction. When compared to conventional radiation therapy, the high response rates, smaller field sizes, shorter treatment times, and reduced radiation dose to adjacent critical tissues makes electronic brachytherapy a useful addition to standard techniques.

Sign in / Sign up

Export Citation Format

Share Document