A Quantitative Assessment of Dual Energy Computed Tomography‐Based Material Decomposition for Imaging Bone Marrow Edema Associated with Acute Knee Injury

2021 ◽  
Author(s):  
Chantal M.J. de Bakker ◽  
Richard E.A. Walker ◽  
Bryce A. Besler ◽  
Justin J. Tse ◽  
Sarah L. Manske ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Marrow ◽  
Quantitative Assessment ◽  
Knee Injury ◽  
Bone Marrow Edema ◽  
Dual Energy ◽  
Material Decomposition ◽  
Acute Knee ◽  
Acute Knee Injury ◽  
Marrow Edema

scholarly journals Diagnostic Accuracy of Dual-energy CT for Bone Marrow Edema in Patients with Acute Knee Injuries: A Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Xuelong Chen ◽  
Zhizhuo Li ◽  
Hui Fang ◽  
Xiangyang Yin ◽  
Chengxin Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bone Marrow ◽  
Knee Injury ◽  
Bone Marrow Edema ◽  
Meta Analysis ◽  
Knee Injuries ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Acute Knee ◽  
Marrow Edema

Abstract Background: The prevalence of knee injury is high and early diagnosis is significant to guide clinical treatment. MRI is recognized as the gold standard for detecting bone marrow edema (BME) in patients with acute knee injury, but limitations still exist. Dual-energy CT (DECT) is investigated as a promising alternative.Methods: We systematically retrieved studies from EMBASE, Scopus, PUBMED, and the Cochrane Library and collected gray literatures. According to PRISMA-DTA guidelines, a systematic review was performed from inception to July 31, 2021, assessing the diagnostic accuracy of DECT for detecting BME in at least 10 adult patients with acute knee injuries and with an MRI reference standard. Study details were independently extracted by two reviewers. Meta-analysis was performed using a bivariate mixed-effects regression model with subgroup analysis performed to evaluate for sources of variability. Results: Nine studies evaluating 290 patients between the ages of 23–53 with acute knee injuries undergoing DECT and MRI were included in analysis. Summary sensitivity, specificity, and AUC values for BME were 85% (95% confidence interval (CI) 77–90%), 96% (95% CI 93–97%), and 0.97 (95% CI 0.95–0.98), respectively. There were no statistically significant differences in specificity and sensitivity amongst comparative subgroups to account for presumed variability amongst studies.Conclusion: DECT is accurate for detecting BME in patients with acute knee injuries and can be used as an alternative to MRI, particularly when MRI is contraindicated or unavailable.

Dual-Energy Computed Tomography Virtual Noncalcium Imaging for the Detection of Acute Bone Marrow Edema in Vertebrae: Qualitative and Quantitative Analysis

2021 ◽  
Vol 11 (3) ◽  
pp. 752-759
Author(s):  
Lingjing Gu ◽  
Jianchao Liang ◽  
Yingying Zhan ◽  
Jielin Pan ◽  
Yi Zhang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Marrow ◽  
Mr Imaging ◽  
Bone Marrow Edema ◽  
Dual Energy ◽  
Grading System ◽  
Qualitative And Quantitative ◽  
Ct Value ◽  
Quantitative Analyses ◽  
Marrow Edema

Purpose: To evaluate the feasibility of dual-energy computed tomography (DECT) virtual noncalcium (VNCa) images for detecting vertebral bone marrow edema (BME), both in qualitative and quantitative analyses. Materials and Methods: Nineteen cases with acute spinal trauma were enrolled. DECT and MR Imaging were performed over an interval of 0–3 days within 3 weeks of injury. Both gray-scale and color-coded VNCa images were evaluated in an independent and blind manner using a three-scale grading system (2 = distinct BME, 1 = suspicious BME, and 0 = no edema) by two radiologists. CT value of bone marrow were measured for each region and subjected to receiver operating characteristic (ROC) curve analysis for diagnosis of BME on VNCa images from DECT. Subsequently, as a standard of reference, MR imaging was evaluated by a third radiologist for the presence of traumatic BME. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for the detection of BME using VNCa images were evaluated. Kappa analysis and one-way ANOVA were performed to evaluate the consistency and variance of VNCa images in the BME. Results: For two observers, the sensitivity of VNCa images for detecting BME (grade 2) were 97.8% and 96.7%, with the specificity 76% and 72%, the PPV 93.8% and 92.7%, the NPV 90.5% and 85.7%, respectively. And the sensitivity for detecting BME (grade 1–2) were 94.3% and 94.3%, with the specificity 96.7% and 93.3%, the PPV 98.8% and 97.6%, the NPV 85.3% and 84.8%, respectively. The consistency test between the two observers showed that Kappa value was 0.650 (P < 0.001). The VNCa images had higher CT value in the positive regions than in the negative regions (P < 0.05). Statistically significant differences in the CT value were identified in different regions with the three-scale grading system (thoracic levels: F = 136.690, P < 0.001; lumbar levels: F = 92.689, P < 0.001). Conclusions: Acute traumatic BME in the vertebrae can be detected on VNCa images in both qualitative and quantitative analyses. DECT VNCa images are expected to serve as an additional method for the evaluation of BME.

Dual-Energy Computed Tomography–Based Display of Bone Marrow Edema in Incidental Vertebral Compression Fractures

2018 ◽  
Vol 53 (7) ◽  
pp. 409-416 ◽  
Author(s):  
Claudia Frellesen ◽  
Mehrnoush Azadegan ◽  
Simon S. Martin ◽  
Katharina Otani ◽  
Tommaso DʼAngelo ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Marrow ◽  
Bone Marrow Edema ◽  
Dual Energy ◽  
Vertebral Compression Fractures ◽  
Dual Energy Computed Tomography ◽  
Compression Fractures ◽  
Marrow Edema

Identification of bone marrow edema around the ankle joint in non-traumatic patients: Diagnostic accuracy of dual-energy computed tomography

2021 ◽  
Vol 69 ◽  
pp. 341-348
Author(s):  
Giovanni Foti ◽  
Massimo Guerriero ◽  
Niccolò Faccioli ◽  
Alessandro Fighera ◽  
Luigi Romano ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Marrow ◽  
Diagnostic Accuracy ◽  
Ankle Joint ◽  
Bone Marrow Edema ◽  
Dual Energy ◽  
Dual Energy Computed Tomography ◽  
Marrow Edema
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