Feasibility study of patient‐specific dose verification in proton therapy utilizing positron emission tomography (PET) and generative adversarial network (GAN)

2020 ◽  
Vol 47 (10) ◽  
pp. 5194-5208
Author(s):  
Saiqun Ma ◽  
Zongsheng Hu ◽  
Kuangkuang Ye ◽  
Xiaoke Zhang ◽  
Yuenan Wang ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Feasibility Study ◽  
Proton Therapy ◽  
Emission Tomography ◽  
Patient Specific ◽  
Dose Verification ◽  
Generative Adversarial Network ◽  
Adversarial Network ◽  
Positron Emission

scholarly journals New Digital Plug and Imaging Sensor for a Proton Therapy Monitoring System Based on Positron Emission Tomography

Sensors ◽  
2018 ◽  
Vol 18 (9) ◽  
pp. 3006 ◽  
Author(s):  
Nicola D’Ascenzo ◽  
Min Gao ◽  
Emanuele Antonecchia ◽  
Paolo Gnudi ◽  
Hsien-Hsin Chen ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Monitoring System ◽  
Proton Therapy ◽  
Therapy Monitoring ◽  
Emission Tomography ◽  
Sensor System ◽  
Reconstruction Algorithms ◽  
Experimental Conditions ◽  
Positron Emission ◽  
Therapy Room

One of the most challenging areas of sensor development for nuclear medicine is the design of proton therapy monitoring systems. Sensors are operated in a high detection rate regime in beam-on conditions. We realized a prototype of a monitoring system for proton therapy based on the technique of positron emission tomography. We used the Plug and Imaging (P&I) technology in this application. This sensing system includes LYSO/silicon photomultiplier (SiPM) detection elements, fast digital multi voltage threshold (MVT) readout electronics and dedicated image reconstruction algorithms. In this paper, we show that the P&I sensor system has a uniform response and is controllable in the experimental conditions of the proton therapy room. The prototype of PET monitoring device based on the P&I sensor system has an intrinsic experimental spatial resolution of approximately 3 mm (FWHM), obtained operating the prototype both during the beam irradiation and right after it. The count-rate performance of the P&I sensor approaches 5 Mcps and allows the collection of relevant statistics for the nuclide analysis. The measurement of both the half life and the relative abundance of the positron emitters generated in the target volume through irradiation of 10 10 protons in approximately 15 s is performed with 0.5% and 5 % accuracy, respectively.

Adaptive planning using positron emission tomography for locally advanced lung cancer: A feasibility study

2016 ◽  
Vol 6 (2) ◽  
pp. 96-104 ◽  
Author(s):  
Chris R. Kelsey ◽  
Jared D. Christensen ◽  
Junzo P. Chino ◽  
Justus Adamson ◽  
Neal E. Ready ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Positron Emission Tomography ◽  
Feasibility Study ◽  
Locally Advanced ◽  
Emission Tomography ◽  
Advanced Lung Cancer ◽  
Adaptive Planning ◽  
Positron Emission ◽  
Locally Advanced Lung Cancer
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