scholarly journals Optimization of hexagonal‐pattern minibeams for spatially fractionated radiotherapy using proton beam scanning

2020 ◽  
Vol 47 (8) ◽  
pp. 3485-3495
Author(s):  
Serdar Charyyev ◽  
Mark Artz ◽  
Gregory Szalkowski ◽  
Chih‐Wei Chang ◽  
Alexander Stanforth ◽  
...  
Keyword(s):  
Proton Beam ◽  
Beam Scanning ◽  
Fractionated Radiotherapy ◽  
Hexagonal Pattern

scholarly journals EP-1729: Dosimetric characterization of a novel phantom for cell irradiation in active proton beam scanning

2018 ◽  
Vol 127 ◽  
pp. S924-S925
Author(s):  
M. Clausen ◽  
S. Khachonkham ◽  
P. Kuess ◽  
B. Knäusl ◽  
D. Georg ◽  
...  
Keyword(s):  
Proton Beam ◽  
Beam Scanning ◽  
Cell Irradiation

Intrafractional motion during proton beam scanning

2005 ◽  
Vol 50 (20) ◽  
pp. 4853-4862 ◽  
Author(s):  
J Lambert ◽  
N Suchowerska ◽  
D R McKenzie ◽  
M Jackson
Keyword(s):  
Proton Beam ◽  
Beam Scanning ◽  
Intrafractional Motion

scholarly journals PV-0571: Transcriptomic changes in fibroblasts irradiated with proton beam scanning or Co-60 gamma rays

2018 ◽  
Vol 127 ◽  
pp. S300-S301
Author(s):  
S. Nielsen ◽  
N. Bassler ◽  
L. Grzanka ◽  
J. Swakoń ◽  
P. Olko ◽  
...  
Keyword(s):  
Proton Beam ◽  
Gamma Rays ◽  
Beam Scanning ◽  
Transcriptomic Changes

Characteristics of proton beam scanning dependent on Li target thickness from the viewpoint of heat removal and material strength for accelerator-based BNCT

2009 ◽  
Vol 67 (2) ◽  
pp. 259-265 ◽  
Author(s):  
Kenichi Tanaka ◽  
Hitoshi Yokobori ◽  
Satoru Endo ◽  
Tooru Kobayashi ◽  
Gerard Bengua ◽  
...  
Keyword(s):  
Proton Beam ◽  
Heat Removal ◽  
Target Thickness ◽  
Material Strength ◽  
Beam Scanning

scholarly journals Respiratory gating for proton beam scanning versus photon 3D-CRT for breast cancer radiotherapy

2016 ◽  
Vol 55 (5) ◽  
pp. 577-583 ◽  
Author(s):  
Anna M. Flejmer ◽  
Anneli Edvardsson ◽  
Frida Dohlmar ◽  
Dan Josefsson ◽  
Mats Nilsson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Proton Beam ◽  
Respiratory Gating ◽  
Beam Scanning ◽  
Cancer Radiotherapy ◽  
Breast Cancer Radiotherapy ◽  
3D Crt

scholarly journals FLASH Proton Pencil Beam Scanning Irradiation Minimizes Radiation-Induced Leg Contracture and Skin Toxicity in Mice

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1012
Author(s):  
Shannon Cunningham ◽  
Shelby McCauley ◽  
Kanimozhi Vairamani ◽  
Joseph Speth ◽  
Swati Girdhani ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Proton Beam ◽  
Skin Toxicity ◽  
Tumor Control ◽  
High Dose ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Dose Rates ◽  
Pencil Beam Scanning ◽  
Tgf Β1

Ultra-high dose rate radiation has been reported to produce a more favorable toxicity and tumor control profile compared to conventional dose rates that are used for patient treatment. So far, the so-called FLASH effect has been validated for electron, photon and scattered proton beam, but not yet for proton pencil beam scanning (PBS). Because PBS is the state-of-the-art delivery modality for proton therapy and constitutes a wide and growing installation base, we determined the benefit of FLASH PBS on skin and soft tissue toxicity. Using a pencil beam scanning nozzle and the plateau region of a 250 MeV proton beam, a uniform physical dose of 35 Gy (toxicity study) or 15 Gy (tumor control study) was delivered to the right hind leg of mice at various dose rates: Sham, Conventional (Conv, 1 Gy/s), Flash60 (57 Gy/s) and Flash115 (115 Gy/s). Acute radiation effects were quantified by measurements of plasma and skin levels of TGF-β1 and skin toxicity scoring. Delayed irradiation response was defined by hind leg contracture as a surrogate of irradiation-induced skin and soft tissue toxicity and by plasma levels of 13 different cytokines (CXCL1, CXCL10, Eotaxin, IL1-beta, IL-6, MCP-1, Mip1alpha, TNF-alpha, TNF-beta, VEGF, G-CSF, GM-CSF and TGF- β1). Plasma and skin levels of TGF-β1, skin toxicity and leg contracture were all significantly decreased in FLASH compared to Conv groups of mice. FLASH and Conv PBS had similar efficacy with regards to growth control of MOC1 and MOC2 head and neck cancer cells transplanted into syngeneic, immunocompetent mice. These results demonstrate consistent delivery of FLASH PBS radiation from 1 to 115 Gy/s in a clinical gantry. Radiation response following delivery of 35 Gy indicates potential benefits of FLASH versus conventional PBS that are related to skin and soft tissue toxicity.

Sign in / Sign up

Export Citation Format

Share Document