scholarly journals Statistical properties of cerebral CT perfusion imaging systems. Part I. Cerebral blood volume maps generated from nondeconvolution‐based systems

2019 ◽  
Vol 46 (11) ◽  
pp. 4869-4880
Author(s):  
Ke Li ◽  
Charles M. Strother ◽  
Guang‐Hong Chen
Keyword(s):  
Blood Volume ◽  
Perfusion Imaging ◽  
Cerebral Blood Volume ◽  
Ct Perfusion ◽  
Statistical Properties ◽  
Imaging Systems ◽  
Ct Perfusion Imaging

Computed Tomographic Perfusion in the Management of Aneurysmal Subarachnoid Hemorrhage: New Application of an Existent Technique

Neurosurgery ◽  
2005 ◽  
Vol 56 (2) ◽  
pp. 304-317 ◽  
Author(s):  
Mark R. Harrigan ◽  
Christopher R. Magnano ◽  
Lee R. Guterman ◽  
L Nelson Hopkins
Keyword(s):  
Cerebral Ischemia ◽  
Blood Volume ◽  
Perfusion Imaging ◽  
Cerebral Blood Volume ◽  
Ct Perfusion ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Delayed Cerebral Ischemia ◽  
Computed Tomographic ◽  
Time To Peak ◽  
Ct Perfusion Imaging

Abstract OBJECTIVE: Cerebral blood flow (CBF) alterations are common after aneurysmal subarachnoid hemorrhage (SAH). Treatment of delayed cerebral ischemia in this setting depends on timely and accurate diagnosis. Techniques to measure cerebral blood flow are useful and important. Computed tomographic (CT) perfusion imaging is a technique for the measurement of CBF, cerebral blood volume, and time to peak. It is a fast and inexpensive brain imaging modality that offers promise in the management of patients with SAH. METHODS: CT perfusion imaging was performed in 10 patients with aneurysmal SAH when neurological changes raised suspicions of cerebral ischemia. Quantitative values for CBF, cerebral blood volume, and time to peak were obtained in each study. The case history, CT perfusion results, and an analysis of how patient management was influenced are presented for each patient. RESULTS: A total of 17 CT perfusion studies were performed. Five studies showed evidence of cerebral ischemia, leading to endovascular treatment of vasospasm. Eight studies excluded cerebral ischemia, and two studies identified cerebral hyperemia, resulting in adjustments in hyperdynamic therapy. CT perfusion was used to help predict a poor prognosis and withhold aggressive intervention in two patients with poor Hunt and Hess grades. Time-to-peak values identified regions of cerebral ischemia more readily than CBF or cerebral blood volume values. CONCLUSION: CT perfusion imaging can be used to identify patients with delayed cerebral ischemia after SAH and to guide medical and endovascular therapy. The findings can lead to alterations in patient management.

Comparison of cerebral blood volume and permeability in preoperative grading of intracranial glioma using CT perfusion imaging

2006 ◽  
Vol 48 (10) ◽  
pp. 773-781 ◽  
Author(s):  
Bei Ding ◽  
Hua Wei Ling ◽  
Ke Min Chen ◽  
Hong Jiang ◽  
Yan Bo Zhu
Keyword(s):  
Blood Volume ◽  
Perfusion Imaging ◽  
Cerebral Blood Volume ◽  
Ct Perfusion ◽  
Ct Perfusion Imaging

scholarly journals Collateral status contributes to differences between observed and predicted 24-h infarct volumes in DEFUSE 3

2020 ◽  
Vol 40 (10) ◽  
pp. 1966-1974 ◽  
Author(s):  
Vaishnavi L Rao ◽  
Michael Mlynash ◽  
Søren Christensen ◽  
Amarnath Yennu ◽  
Stephanie Kemp ◽  
...  
Keyword(s):  
Blood Volume ◽  
Perfusion Imaging ◽  
Intensity Ratio ◽  
Cerebral Blood Volume ◽  
Ct Perfusion ◽  
Infarct Volume ◽  
Ct Perfusion Imaging

We previously demonstrated that in the DEFUSE 3 trial, the union of the baseline core and the 24-h Tmax > 6 s perfusion lesion predicts the infarct volume at 24 h. Presently, we assessed if collateral robustness measured by the hypoperfusion intensity ratio (HIR) and cerebral blood volume (CBV) index accounts for the variance in these predictions. DEFUSE 3 patients underwent MRI/CT perfusion imaging at baseline and 24 h post-randomization. We compared baseline and follow-up HIR and CBV index across subgroups stratified by differences between predicted and observed 24-h infarct volumes. Of 123 eligible patients, 34 with 24-h infarcts larger than predicted had less favorable collaterals at baseline (HIR 0.43 vs. 0.32, p = 0.006; CBV Index 0.78 vs. 0.85, p = 0.001) and 24 h (HIR 0.56 vs. 0.07, p = 0.004; CBV Index 0.47 vs. 0.73, p = 0.006) compared to 71 patients with more accurate infarct volume prediction. Eighteen patients with 24-h infarcts smaller than predicted had similar baseline collateral scores but more favorable 24-h CBV indices (0.81 vs. 0.73, p = 0.040). Overall, patients with 24-h infarcts larger than predicted had evidence of less favorable baseline collaterals that fail within 24 h, while patients with 24-h infarcts smaller than predicted typically had favorable collaterals that persisted for 24 h.

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