Reply to “Comment on Methodological accuracy of image‐based electron density assessment using dual‐energy computed tomography” [Med. Phys. 44, 2429–2437 (2017)]

2019 ◽  
Vol 46 (2) ◽  
pp. 1077-1078
Author(s):  
Christian Möhler ◽  
Patrick Wohlfahrt ◽  
Christian Richter ◽  
Steffen Greilich
Keyword(s):  
Computed Tomography ◽  
Electron Density ◽  
Dual Energy ◽  
Dual Energy Computed Tomography ◽  
Density Assessment

scholarly journals Methodological accuracy of image-based electron density assessment using dual-energy computed tomography

2017 ◽  
Vol 44 (6) ◽  
pp. 2429-2437 ◽  
Author(s):  
Christian Möhler ◽  
Patrick Wohlfahrt ◽  
Christian Richter ◽  
Steffen Greilich
Keyword(s):  
Computed Tomography ◽  
Electron Density ◽  
Dual Energy ◽  
Dual Energy Computed Tomography ◽  
Density Assessment

Correlation of dual energy computed tomography electron density measurements with cerebral glioma grade

2021 ◽  
pp. 197140092110474
Author(s):  
Ritwik Chakrabarti ◽  
Vivek Gupta ◽  
Sameer Vyas ◽  
Kirti Gupta ◽  
Vikram Singh
Keyword(s):  
Computed Tomography ◽  
Electron Density ◽  
Dual Energy ◽  
Low Grade ◽  
High Grade ◽  
Cerebral Glioma ◽  
Density Measurements ◽  
Dual Energy Computed Tomography ◽  
Low Grade Gliomas ◽  
High Grade Gliomas

Objective To correlate dual energy computed tomography electron density measurements with histopathological cerebral glioma grading to determine whether it can be used as a non-invasive predictor of cerebral glioma grade. Materials and methods Fifty patients with suspected cerebral gliomas on imaging scheduled to undergo resection were included. We tested our hypothesis that with increasing glioma grade, increased tumor cellularity should translate into increased electron density and if a statistically significant difference between electron density of low-grade gliomas and high-grade gliomas is seen, we may have a clinical use of dual energy computed tomography as a non-invasive tool to predict cerebral glioma grade. A pre-operative dual energy computed tomography scan of the brain was performed, and electron density measurements calculated from the solid part of the tumor. Obtaining a ratio with electron density of contralateral normal brain parenchyma normalized these values. The minimum, maximum and mean electron density and their normalized values recorded between high-grade gliomas and low-grade gliomas were compared for presence of statistical significance. Results A statistically significant difference was found between all six parameters recorded (minimum electron density and normalized values, mean electron density and normalized values, maximum electron density and normalized values) between low-grade gliomas and high-grade gliomas. The predictivity ranged from 75% (for minimum electron density and maximum normalized values) to 81.25% (for mean normalized values). All six parameters were found to have statistically significant positive correlation with Ki-67 index. Conclusion Dual energy computed tomography electron density measurements in cerebral gliomas are predictive of pre-operative differentiation of low-grade gliomas from high-grade gliomas and show a linear, statistically significant positive correlation with Ki-67 index.

Experimental feasibility of dual-energy computed tomography based on the Thomson scattering X-ray source

2018 ◽  
Vol 25 (6) ◽  
pp. 1797-1802 ◽  
Author(s):  
Zhijun Chi ◽  
Yingchao Du ◽  
Lixin Yan ◽  
Dong Wang ◽  
Hongze Zhang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Electron Density ◽  
Light Source ◽  
Atomic Number ◽  
Effective Atomic Number ◽  
Thomson Scattering ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
X Ray ◽  
Dual Energy Computed Tomography

Unlike large-scale and expensive synchrotron radiation facilities, the Thomson scattering X-ray source can provide quasi-monochromatic, energy-tunable and high-brightness X-ray pulses with a small footprint and moderate cost, making it an excellent candidate for dual-energy and multi-energy imaging at laboratories and hospitals. Here, the first feasibility study on dual-energy computed tomography (CT) based on this type of light source is reported, and the effective atomic number and electron-density distribution of a standard phantom consisting of polytetrafluoroethylene, water and aluminium is derived. The experiment was carried out at the Tsinghua Thomson scattering X-ray source with peak energies of 29 keV and 68 keV. Both the reconstructed effective atomic numbers and the retrieved electron densities of the three materials were compared with their theoretical values. It was found that these values were in agreement by 0.68% and 2.60% on average for effective atomic number and electron density, respectively. These results have verified the feasibility of dual-energy CT based on the Thomson scattering X-ray source and will further expand the scope of X-ray imaging using this type of light source.

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