Spatially fractionated (GRID) radiation therapy using proton pencil beam scanning (PBS): Feasibility study and clinical implementation

2018 ◽  
Vol 45 (4) ◽  
pp. 1645-1653 ◽  
Author(s):  
M. Gao ◽  
M. M. Mohiuddin ◽  
W. F. Hartsell ◽  
M. Pankuch
Keyword(s):  
Radiation Therapy ◽  
Feasibility Study ◽  
Pencil Beam ◽  
Clinical Implementation ◽  
Beam Scanning ◽  
Pencil Beam Scanning

Pencil beam scanning proton therapy vs rotational arc radiation therapy: A treatment planning comparison for postoperative oropharyngeal cancer

2017 ◽  
Vol 42 (1) ◽  
pp. 7-11 ◽  
Author(s):  
Ontida Apinorasethkul ◽  
Maura Kirk ◽  
Kevin Teo ◽  
Samuel Swisher-McClure ◽  
John N. Lukens ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Treatment Planning ◽  
Proton Therapy ◽  
Oropharyngeal Cancer ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Pencil Beam Scanning

Implementation of planar proton minibeam radiation therapy using a pencil beam scanning system: A proof of concept study

2018 ◽  
Vol 45 (11) ◽  
pp. 5305-5316 ◽  
Author(s):  
Ludovic De Marzi ◽  
Annalisa Patriarca ◽  
Catherine Nauraye ◽  
Eric Hierso ◽  
Rémi Dendale ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Scanning System ◽  
Pencil Beam ◽  
Proof Of Concept ◽  
Beam Scanning ◽  
Concept Study ◽  
Pencil Beam Scanning ◽  
System A

scholarly journals Clinical Implementation of Proton Therapy Using Pencil-Beam Scanning Delivery Combined With Static Apertures

2021 ◽  
Vol 11 ◽  
Author(s):  
Christian Bäumer ◽  
Sandija Plaude ◽  
Dalia Ahmad Khalil ◽  
Dirk Geismar ◽  
Paul-Heinz Kramer ◽  
...  
Keyword(s):  
At Risk ◽  
Proton Therapy ◽  
Target Volume ◽  
Delivery Mode ◽  
Pencil Beam ◽  
Clinical Implementation ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Spot Scanning ◽  
The Mean

Proton therapy makes use of the favorable depth-dose distribution with its characteristic Bragg peak to spare normal tissue distal of the target volume. A steep dose gradient would be desired in lateral dimensions, too. The widespread spot scanning delivery technique is based, however, on pencil-beams with in-air spot full-widths-at-half-maximum of typically 1 cm or more. This hampers the sparing of organs-at-risk if small-scale structures adjacent to the target volume are concerned. The trimming of spot scanning fields with collimating apertures constitutes a simple measure to increase the transversal dose gradient. The current study describes the clinical implementation of brass apertures in conjunction with the pencil-beam scanning delivery mode at a horizontal, clinical treatment head based on commercial hardware and software components. Furthermore, clinical cases, which comprised craniopharyngiomas, re-irradiations and ocular tumors, were evaluated. The dosimetric benefits of 31 treatment plans using apertures were compared to the corresponding plans without aperture. Furthermore, an overview of the radiation protection aspects is given. Regarding the results, robust optimization considering range and setup uncertainties was combined with apertures. The treatment plan optimizations followed a single-field uniform dose or a restricted multi-field optimization approach. Robustness evaluation was expanded to account for possible deviations of the center of the pencil-beam delivery and the mechanical center of the aperture holder. Supplementary apertures improved the conformity index on average by 15.3%. The volume of the dose gradient surrounding the PTV (evaluated between 80 and 20% dose levels) was decreased on average by 17.6%. The mean dose of the hippocampi could be reduced on average by 2.9 GyRBE. In particular cases the apertures facilitated a sparing of an organ-at-risk, e.g. the eye lens or the brainstem. For six craniopharyngioma cases the inclusion of apertures led to a reduction of the mean dose of 1.5 GyRBE (13%) for the brain and 3.1 GyRBE (16%) for the hippocampi.

SU-E-T-267: Proton Pencil Beam Scanning for Mediastinal Lymphoma: 4-Dimensional Feasibility Study

2014 ◽  
Vol 41 (6Part15) ◽  
pp. 285-285
Author(s):  
C Zeng ◽  
J Plastaras ◽  
Z Tochner ◽  
C Hill-Kayser ◽  
S Hahn ◽  
...  
Keyword(s):  
Feasibility Study ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Mediastinal Lymphoma

scholarly journals Dosimetric Comparison of Pencil-Beam Scanning and Photon-Based Radiation Therapy as a Boost in Carcinoma of Cervix

2017 ◽  
Vol 4 (2) ◽  
pp. 1-10 ◽  
Author(s):  
Manoj K. Sharma ◽  
Eugen B. Hug ◽  
Manindra Bhushan ◽  
Dennis Mah ◽  
Dominic Maes ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Dosimetric Comparison ◽  
Pencil Beam Scanning ◽  
Carcinoma Of Cervix

PO-1611: Clinical implementation of liver cancer treatments with pencil beam scanning proton therapy

2020 ◽  
Vol 152 ◽  
pp. S877
Author(s):  
F. Fracchiolla ◽  
F. Dionisi ◽  
R. Righetto ◽  
L. Widesott ◽  
I. Giacomelli ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Proton Therapy ◽  
Pencil Beam ◽  
Clinical Implementation ◽  
Cancer Treatments ◽  
Beam Scanning ◽  
Pencil Beam Scanning
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