scholarly journals On the feasibility of automatically selecting similar patients in highly individualized radiotherapy dose reconstruction for historic data of pediatric cancer survivors

2018 ◽  
Vol 45 (4) ◽  
pp. 1504-1517 ◽  
Author(s):  
Marco Virgolin ◽  
Irma W. E. M. van Dijk ◽  
Jan Wiersma ◽  
Cécile M. Ronckers ◽  
Cees Witteveen ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Pediatric Cancer ◽  
Dose Reconstruction ◽  
Pediatric Cancer Survivors ◽  
Individualized Radiotherapy ◽  
Historic Data ◽  
Radiotherapy Dose

Neurocognitive Deficits and IEP Monitoring of Pediatric Cancer Survivors

2006 ◽  
Author(s):  
Irene Delgado ◽  
Maria L. Goldman ◽  
Mary Whitney Ward ◽  
Monica Bocanegra ◽  
Erin O'Callaghan ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Pediatric Cancer ◽  
Neurocognitive Deficits ◽  
Pediatric Cancer Survivors

Exercise cardiac MRI unmasks cardiac dysfunction in childhood and adolescent cancer survivors with reduced cardiopulmonary fitness

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
S Foulkes ◽  
B Costello ◽  
E.J Howden ◽  
K Janssens ◽  
H Dillon ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiac Function ◽  
Cancer Survivors ◽  
Pediatric Cancer ◽  
Cardiac Dysfunction ◽  
Cardiopulmonary Fitness ◽  
Cardiac Reserve ◽  
Pediatric Cancer Survivors ◽  
Increased Risk

Abstract Background Young cancer survivors are at increased risk of impaired cardiopulmonary fitness (VO2peak) and heart failure. Assessment of exercise cardiac reserve may reveal sub-clinical abnormalities that better explain impairments in fitness and long term heart failure risk. Purpose To investigate the presence of impaired VO2peak in pediatric cancer survivors with increased risk of heart failure, and to assess its relationship with resting cardiac function and cardiac reserve Methods Twenty pediatric cancer survivors (aged 8–24 years) treated with anthracycline chemotherapy underwent cardiopulmonary exercise testing to quantify VO2peak, with a value <85% of predicted defined as impaired VO2peak. Resting cardiac function was assessed using 3-dimensional echocardiography, with cardiac reserve quantified from resting and peak exercise heart rate (HR), stroke volume index (SVi) and cardiac index (CI) using exercise cardiac magnetic resonance imaging. Results 12 of 20 survivors (60%) had impaired VO2peak (97±14% vs. 70±16% of age and gender predicted). There were no differences in echocardiographic or CMR measurements of resting cardiac function between survivors with normal or impaired VO2peak. However, those with reduced VO2peak had diminished cardiac reserve, with a lesser increase in CI (Fig. 1A) and SVi (Fig. 1B) during exercise (Interaction P=0.001 for both), whilst the HR response was similar (Fig. 1C; P=0.71). Conclusions Resting measures of cardiac function are insensitive to significant cardiac dysfunction amongst pediatric cancer survivors with reduced VO2peak. Measures of cardiopulmonary fitness and cardiac reserve may aid in early identification of survivors with heightened risk of long-term heart failure. Figure 1 Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): National Heart Foundation

scholarly journals Fear of progression in parents of childhood cancer survivors: prevalence and associated factors

2021 ◽  
Author(s):  
Mona L. Peikert ◽  
Laura Inhestern ◽  
Konstantin A. Krauth ◽  
Gabriele Escherich ◽  
Stefan Rutkowski ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Pediatric Cancer ◽  
Coping Style ◽  
Associated Factors ◽  
Childhood Cancer Survivors ◽  
Cns Tumor ◽  
Mothers And Fathers ◽  
Fear Of Progression ◽  
Pediatric Cancer Survivors

Abstract Purpose Recent research demonstrated that fear of progression (FoP) is a major burden for adult cancer survivors. However, knowledge on FoP in parents of childhood cancer survivors is scarce. This study aimed to determine the proportion of parents who show dysfunctional levels of FoP, to investigate gender differences, and to examine factors associated with FoP in mothers and fathers. Methods Five hundred sixteen parents of pediatric cancer survivors (aged 0–17 years at diagnosis of leukemia or central nervous system (CNS) tumor) were consecutively recruited after the end of intensive cancer treatment. We conducted hierarchical multiple regression analyses for mothers and fathers and integrated parent-, patient-, and family-related factors in the models. Results Significantly more mothers (54%) than fathers (41%) suffered from dysfunctional levels of FoP. Maternal FoP was significantly associated with depression, a medical coping style, a child diagnosed with a CNS tumor in comparison to leukemia, and lower family functioning (adjusted R2 = .30, p < .001). Paternal FoP was significantly associated with a lower level of education, depression, a family coping style, a child diagnosed with a CNS tumor in comparison to leukemia, and fewer siblings (adjusted R2 = .48, p < .001). Conclusions FoP represents a great burden for parents of pediatric cancer survivors. We identified associated factors of parental FoP. Some of these factors can be targeted by health care professionals within psychosocial interventions and others can provide an indication for an increased risk for higher levels of FoP. Implications for Cancer Survivors Psychosocial support targeting FoP in parents of childhood cancer survivors is highly indicated.

Abstract 18153: Abnormal Dynamic Myocardial Response to Exercise Despite Normal Resting Ejection Fraction in Childhood Cancer Survivors Treated With Anthracyclines

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Ching Kit - Chen ◽  
Barbara Cifra ◽  
Cameron Slorach ◽  
Cedric Manlhiot ◽  
Brian W McCrindle ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Pediatric Cancer ◽  
Lateral Wall ◽  
Childhood Cancer Survivors ◽  
Peak Exercise ◽  
Force Frequency ◽  
Exercise Echocardiography ◽  
Pediatric Cancer Survivors ◽  
Basal Septum ◽  
Response To Exercise

Introduction: There are limited data on myocardial systolic & diastolic response to exercise in pediatric cancer survivors treated with anthracycline. We used exercise echocardiography to evaluate ventricular systolic and diastolic reserve in these patients. Methods: 50 children (age 14.4±2.4 years) who had received anthracycline treatment with median dose 178mg/m 2 (range 60-450) underwent stepwise exercise echocardiography at 9.3±2.9 years after end of therapy, and compared with 50 normal controls. All subjects had normal resting LVEF. Peak systolic (s’) & early diastolic (e’) myocardial velocities in the LV & RV lateral wall, & basal septum were measured at rest & during exercise using color TDI. Measurements of myocardial isovolumic acceleration (IVA) at incremental heart rates (HR) were used to study force-frequency relationships (FFR). Results: At rest, LV systolic parameters were preserved in patients; septal e’ was significantly lower compared to controls (10.4±1.9cm/s vs 11.4±1.9cm/s; p =0.009). At peak exercise, LV & RV lateral wall, & basal septal e’ velocities were lower in patients (17.4±3.8cm/s vs 19.6±3.1cm/s, p =0.002; 21.5±1.6cm/s vs 22.3±1.9cm/s, p =0.02; & 16.3±2.4cm/s vs 18.7±2.7cm/s, p <0.001; respectively) & the slopes of change with increasing HR were significantly lower in patients for LV lateral e’ [EST (SE): +0.68 (0.08) vs +0.85 (0.05) cm/s per 10 bpm; p <0.001], RV lateral e’ [+1.47 (0.05) vs 1.69 (0.06) cm/s per 10 bpm; p <0.001] & basal septum e’ [+0.50 (0.05) vs 0.58 (0.05) cm/s per 10 bpm; p =0.001]. During exercise, peak contractile force developed by patients was significantly lower (LV IVA 5.12±1.85m/s 2 vs 6.75±3.28m/s 2 ; p =0.004). FFR analysis showed reduced rate-contractility trajectory in patients [+0.202 (0.008) vs +0.217 (0.008) natural log m/s 2 per 10 bpm; p =0.001]. Conclusions: Long-term survivors of anthracycline-treated pediatric cancer have reduced systolic & diastolic myocardial reserve in response to exercise.

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