scholarly journals A novel method for quantification of beam's-eye-view tumor tracking performance

2017 ◽  
Vol 44 (11) ◽  
pp. 5650-5659 ◽  
Author(s):  
Yue-Houng Hu ◽  
Marios Myronakis ◽  
Joerg Rottmann ◽  
Adam Wang ◽  
Daniel Morf ◽  
...  
2018 ◽  
Vol 8 (12) ◽  
pp. 2525 ◽  
Author(s):  
Timothy Rozario ◽  
Tsuicheng Chiu ◽  
Mingli Chen ◽  
Xun Jia ◽  
Weiguo Lu ◽  
...  

A novel method was developed to track lung tumor motion in real time during radiation therapy with the purpose to allow target radiation dose escalation while simultaneously reducing the dose to sensitive structures, thereby increasing local control without increasing toxicity. This method analyzes beam’s eye view radiation therapy treatment megavoltage (MV) images with simulated digitally reconstructed radiographs (DRRs) as references. Instead of comparing global DRRs with projection images, this method incorporates a technique that divides the global composite DRR and the corresponding MV projection into sub-images called tiles. Registration is performed independently on tile pairs in order to reduce the effects of global discrepancies due to scattering or imaging modality differences. This algorithm was evaluated by phantom studies while simulated tumors were controlled to move with various patterns in a complex humanoid torso. Approximately 15,000 phantom MV images were acquired at nine gantry angles, with different tumors moving within ranges between 10 and 20 mm. Tumors were successfully identified on every projection with a total maximum/average error of 1.84/0.98 mm. This algorithm was also applied to over 5,000 frames of MV projections acquired during radiation therapy of five lung cancer patients. This tumor-tracking methodology is capable of accurately locating lung tumors during treatment without implanting any internal fiducial markers nor delivering extra imaging radiation doses.


2014 ◽  
Vol 41 (6Part8) ◽  
pp. 180-180
Author(s):  
X Shi ◽  
J Lin ◽  
T Diwanji ◽  
K Mooney ◽  
W D' Souza ◽  
...  

Author(s):  
M.A. Gregory ◽  
G.P. Hadley

The insertion of implanted venous access systems for children undergoing prolonged courses of chemotherapy has become a common procedure in pediatric surgical oncology. While not permanently implanted, the devices are expected to remain functional until cure of the primary disease is assured. Despite careful patient selection and standardised insertion and access techniques, some devices fail. The most commonly encountered problems are colonisation of the device with bacteria and catheter occlusion. Both of these difficulties relate to the development of a biofilm within the port and catheter. The morphology and evolution of biofilms in indwelling vascular catheters is the subject of ongoing investigation. To date, however, such investigations have been confined to the examination of fragments of biofilm scraped or sonicated from sections of catheter. This report describes a novel method for the extraction of intact biofilms from indwelling catheters.15 children with Wilm’s tumour and who had received venous implants were studied. Catheters were removed because of infection (n=6) or electively at the end of chemotherapy.


GeroPsych ◽  
2012 ◽  
Vol 25 (4) ◽  
pp. 235-245 ◽  
Author(s):  
Katja Franke ◽  
Christian Gaser

We recently proposed a novel method that aggregates the multidimensional aging pattern across the brain to a single value. This method proved to provide stable and reliable estimates of brain aging – even across different scanners. While investigating longitudinal changes in BrainAGE in about 400 elderly subjects, we discovered that patients with Alzheimer’s disease and subjects who had converted to AD within 3 years showed accelerated brain atrophy by +6 years at baseline. An additional increase in BrainAGE accumulated to a score of about +9 years during follow-up. Accelerated brain aging was related to prospective cognitive decline and disease severity. In conclusion, the BrainAGE framework indicates discrepancies in brain aging and could thus serve as an indicator for cognitive functioning in the future.


Author(s):  
K. Botterill ◽  
R. Allen ◽  
P. McGeorge

The Multiple-Object Tracking paradigm has most commonly been utilized to investigate how subsets of targets can be tracked from among a set of identical objects. Recently, this research has been extended to examine the function of featural information when tracking is of objects that can be individuated. We report on a study whose findings suggest that, while participants can only hold featural information for roughly two targets this task does not affect tracking performance detrimentally and points to a discontinuity between the cognitive processes that subserve spatial location and featural information.


1954 ◽  
Author(s):  
E. J. Archer ◽  
L. B. Wyckoff ◽  
F. G. Brown
Keyword(s):  

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