Total variation based DCE-MRI decomposition by separating lesion from background for time-intensity curve estimation

2017 ◽  
Vol 44 (6) ◽  
pp. 2321-2331 ◽  
Author(s):  
Hui Liu ◽  
Yuanjie Zheng ◽  
Dong Liang ◽  
Pinpin Tang ◽  
Fuquan Ren ◽  
...  
Keyword(s):  
Total Variation ◽  
Intensity Curve ◽  
Time Intensity Curve ◽  
Curve Estimation ◽  
Dce Mri

Motion Correction for Liver DCE-MRI with Time-Intensity Curve Constraint

2021 ◽  
pp. 733-742
Author(s):  
Yuhang Sun ◽  
Dongming Wei ◽  
Zhiming Cui ◽  
Yujia Zhou ◽  
Caiwen Jiang ◽  
...  
Keyword(s):  
Motion Correction ◽  
Intensity Curve ◽  
Time Intensity Curve ◽  
Dce Mri

Reproducibility of DCE-MRI time-intensity curve-shape analysis in patients with knee arthritis: A comparison with qualitative and pharmacokinetic analyses

2015 ◽  
Vol 42 (6) ◽  
pp. 1497-1506 ◽  
Author(s):  
Christiaan van der Leij ◽  
Cristina Lavini ◽  
Marleen G.H. van de Sande ◽  
Marjolein J.H. de Hair ◽  
Christophe Wijffels ◽  
...  
Keyword(s):  
Shape Analysis ◽  
Curve Shape ◽  
Intensity Curve ◽  
Time Intensity Curve ◽  
Knee Arthritis ◽  
Dce Mri

Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Diagnostic Tool in the Assessment of Tumour Angiogenesis in Urinary Bladder Cancer

2019 ◽  
Vol 70 (3) ◽  
pp. 254-263 ◽  
Author(s):  
Omar Ahmad Hassanien ◽  
Rasha T. Abouelkheir ◽  
Mohamed Ibrahim Abou El-Ghar ◽  
Manal Ezzat Badawy ◽  
Samir Abdel-hakim El Gamal ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Signal Intensity ◽  
Bladder Tumour ◽  
Urinary Bladder Cancer ◽  
Time Signal ◽  
Intensity Curve ◽  
Tumour Angiogenesis ◽  
Signal Intensity Curve ◽  
Dce Mri ◽  
Contrast Enhanced

Purpose The aim of study is to assess the role of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and correlation with tumour angiogenesis in evaluation of urinary bladder cancer. Material and Methods The study included 81 patients with recent presumed diagnosis of bladder tumour or who came for follow up after management of histopathologically proven bladder cancer. All had DCE-MRI with time–signal intensity curve. The radiologic results then correlated with the histopathologic results using both haematoxylin and eosin stain and immuno-histochemical staining for localization and evaluation of CD34 immunoreactivity as a detector for the microvessel density (MVD) and tumour angiogenesis. Results Seventy-one cases were pathologically proven to be malignant: 41 cases (58%) showed type III time–signal intensity curve (descending); 22 cases (31%) showed type II (plateau); and 8 cases (11%) showed type I (ascending) curve. The sensitivity of DCE-MRI in stage T1 bladder tumour was 80%; in stage T2, it was (90.9%); and in stage T3, it was (96.9%). Overall accuracy of DCE-MRI in tumour staging was 89.5% and P = .001 (significant). Values more than the cutoff value = 76.13 MVD are cystitis with sensitivity (90%), specificity (91%), and P value is .001, which is statistically highly significant. Conclusion There is a strong positive association between DCE-MRI (staging and washout slope of the time–signal intensity curve) with histopathologic grade, tumour stage, and MVD in bladder cancer. So, DCE-MRI can be used as reliable technique in preoperative predictions of tumour behavior and affect the planning of antiangiogenetic therapy.

scholarly journals Time-intensity-curve Analysis and Tumor Extravasation of Nanobubble Ultrasound Contrast Agents

2019 ◽  
Vol 45 (9) ◽  
pp. 2502-2514 ◽  
Author(s):  
Hanping Wu ◽  
Eric C. Abenojar ◽  
Reshani Perera ◽  
Al Christopher De Leon ◽  
Tianzhi An ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Ultrasound Contrast Agents ◽  
Curve Analysis ◽  
Intensity Curve ◽  
Time Intensity Curve ◽  
Ultrasound Contrast

scholarly journals Relative time-intensity curve: a new method to differentiate benign and malignant lesions on breast MRI

2014 ◽  
Vol 14 (S1) ◽  
Author(s):  
H Sherif ◽  
A Mahfouz ◽  
A Kambal ◽  
A Sayedin ◽  
I Mujeeb
Keyword(s):  
Breast Mri ◽  
New Method ◽  
Intensity Curve ◽  
Time Intensity Curve ◽  
Relative Time ◽  
Malignant Lesions

scholarly journals Changes in Tumor Stem Cell Markers and Epithelial-Mesenchymal Transition Markers in Nonluminal Breast Cancer after Neoadjuvant Chemotherapy and Their Correlation with Contrast-Enhanced Ultrasound

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Xiaoling Leng ◽  
Guofu Huang ◽  
Lianhua Zhang ◽  
Jianbing Ding ◽  
Fucheng Ma
Keyword(s):  
Breast Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Two Dimensional ◽  
Intensity Curve ◽  
Time Intensity Curve ◽  
Mesenchymal Transition ◽  
Contrast Enhanced ◽  
Response To Chemotherapy ◽  
Perfusion Defects ◽  
Emt Markers

Nonluminal breast cancer has high early metastasis and treatment resistance, and neoadjuvant chemotherapy (NAC) is needed. The presence of cancer stem cells (CSC) and epithelial-mesenchymal transition (EMT) leads to poor prognosis. This study investigated the changes in CSC markers and EMT markers after NAC in nonluminal breast cancer and their correlation with contrast-enhanced ultrasound (CEUS) features and chemotherapy efficacy. Before NAC, the range of nonluminal breast cancer on CEUS was larger than that of two-dimensional ultrasound, but after NAC, it was significantly smaller than that of two-dimensional ultrasound and closer to the postoperative pathological size. After NAC, the enlarged lesions and perfusion defects were significantly less than those before NAC. The time-intensity curve showed the characteristics of slow-in, low enhancement, and low perfusion. Nonluminal breast cancer downregulated the expression of CSC markers and EMT markers after NAC, but the epithelial phenotype of nonluminal breast cancer with good response to chemotherapy was upregulated. In nonluminal breast cancer with poor response to chemotherapy, markers of CSC and EMT were highly expressed before chemotherapy. In conclusion, CEUS is better than conventional ultrasound in estimating NAC efficacy in this mode. CEUS can also predict the prognosis of nonluminal breast cancer before NAC with the characteristics of enhanced enlargement and perfusion defects. The contrast-enhanced time-intensity curve of lesions with relatively poor blood supply may have more CSC and EMT characteristics.

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