Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 2: A treatment planning study

2017 ◽  
Vol 44 (5) ◽  
pp. 1993-2001 ◽  
Author(s):  
Lidia Strigari ◽  
Veronica Ferrero ◽  
Giovanni Visonà ◽  
Federico Dalmasso ◽  
Andrea Gobbato ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Treatment Planning ◽  
Planning Study ◽  
Dose Enhancement

Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 1: A radiobiological model study

2017 ◽  
Vol 44 (5) ◽  
pp. 1983-1992 ◽  
Author(s):  
Veronica Ferrero ◽  
Giovanni Visonà ◽  
Federico Dalmasso ◽  
Andrea Gobbato ◽  
Piergiorgio Cerello ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Dose Enhancement ◽  
Model Study ◽  
Radiobiological Model

scholarly journals Dose enhancement effects of gold nanoparticles specifically targeting RNA in breast cancer cells

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0190183 ◽  
Author(s):  
Georg Hildenbrand ◽  
Philipp Metzler ◽  
Götz Pilarczyk ◽  
Vladimir Bobu ◽  
Wilhelm Kriz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Dose Enhancement

Simultaneous integrated boost for breast cancer using imrt: a radiobiological and treatment planning study

2004 ◽  
Vol 59 (5) ◽  
pp. 1513-1522 ◽  
Author(s):  
Mariana Guerrero ◽  
X.Allen Li ◽  
Matthew A. Earl ◽  
Mehrdad Sarfaraz ◽  
Edward Kiggundu
Keyword(s):  
Breast Cancer ◽  
Treatment Planning ◽  
Simultaneous Integrated Boost ◽  
Planning Study ◽  
Integrated Boost

Dosimetry and Radioenhancement Comparison of Gold Nanoparticles in Kilovoltage and Megavoltage Radiotherapy using MAGAT Polymer Gel Dosimeter

2019 ◽  
Vol 9 (2Apr) ◽  
Author(s):  
S Farahani ◽  
N Riyahi Alam ◽  
S Haghgoo ◽  
M Khoobi ◽  
Gh Geraily ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
3D Visualization ◽  
Energy Levels ◽  
Polymer Gel ◽  
External Radiotherapy ◽  
Dose Enhancement ◽  
Internal Radiotherapy ◽  
Boost Radiotherapy

Background: Numerous unique characteristics of the nanosized gold, including high atomic number, low toxicity, and high biocompatibility make it one of the most appropriate nanostructures to boost radiotherapy efficacy. Many in-vivo and in-vitro investigations have indicated that gold nanoparticles (AuNPs) can significantly increase tumor injuries in low kilovoltage radiotherapy. While deep-lying tumors require much higher energy levels with greater penetration power, and investigations carried out in megavoltage energy range show contradictory results.Objective: In this study, we quantitatively assess and compare dose enhancement factors (DEFs) obtained through AuNPs under radiation of Cobalt-60 source (1.25MeV) versus Iridium-192 source (0.380 KeV) using MAGAT gel dosimeter.Material and Methods: MAGAT polymer gel in both pure and combined with 0.2 mM AuNPs was synthesized. In order to quantify the effect of energy on DEF, irradiation was carried out by Co-60 external radiotherapy and Ir-192 internal radiotherapy. Finally, readings of irradiated and non-irradiated gels were performed by MR imaging.Result: The radiation-induced R2 (1/T2) changes of the gel tubes doped with AuNPs compared to control samples, upon irradiation of beams released by Ir-192 source showed a significant dose enhancement (15.31% ±0.30) relative to the Co-60 external radiotherapy (5.85% ±0.14).Conclusion: This preliminary study suggests the feasibility of using AuNPs in radiation therapy (RT), especially in low-energy sources of brachytherapy. In addition, MAGAT polymer gel, as a powerful dosimeter, could be used for 3D visualization of radiation dose distribution of AuNPs in radiotherapy.

scholarly journals A proof of concept treatment planning study of gated proton radiotherapy for cardiac soft tissue sarcoma

2021 ◽  
Vol 19 ◽  
pp. 78-84
Author(s):  
Hyeri Lee ◽  
Jennifer Pursley ◽  
Hsiao-Ming Lu ◽  
Judith Adams ◽  
Thomas DeLaney ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Treatment Planning ◽  
Proof Of Concept ◽  
Proton Radiotherapy ◽  
Planning Study

scholarly journals Phosphatidylserine-Gold Nanoparticles (PS-AuNP) Induce Prostate and Breast Cancer Cell Apoptosis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1094
Author(s):  
Allan Radaic ◽  
Nam E. Joo ◽  
Soo-Hwan Jeong ◽  
Seong-II Yoo ◽  
Nicholas Kotov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Biomedical Applications ◽  
Therapeutic Potential ◽  
Control Treatment ◽  
Track Record ◽  
Males And Females ◽  
Breast And Prostate Cancer ◽  
First Time

Prostate and breast cancer are the current leading causes of new cancer cases in males and females, respectively. Phosphatidylserine (PS) is an essential lipid that mediates macrophage efferocytosis and is dysregulated in tumors. Therefore, developing therapies that selectively restore PS may be a potential therapeutic approach for carcinogenesis. Among the nanomedicine strategies for delivering PS, biocompatible gold nanoparticles (AuNPs) have an extensive track record in biomedical applications. In this study, we synthesized biomimetic phosphatidylserine-caped gold nanoparticles (PS-AuNPs) and tested their anticancer potential in breast and prostate cancer cells in vitro. We found that both cell lines exhibited changes in cell morphology indicative of apoptosis. After evaluating for histone-associated DNA fragments, a hallmark of apoptosis, we found significant increases in DNA fragmentation upon PS-AuNP treatment compared to the control treatment. These findings demonstrate the use of phosphatidylserine coupled with gold nanoparticles as a potential treatment for prostate and breast cancer. To the best of our knowledge, this is the first time that a phosphatidylserine-capped AuNP has been examined for its therapeutic potential in cancer therapy.

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