Menthol from Mentha piperita Suppresses the Milk Production of Lactating Mammary Epithelial Cells In Vivo and In Vitro

2020 ◽  
Vol 64 (24) ◽  
pp. 2000853
Author(s):  
Norihiro Suzuki ◽  
Yusaku Tsugami ◽  
Haruka Wakasa ◽  
Takahiro Suzuki ◽  
Takanori Nishimura ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Milk Production ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Mentha Piperita

scholarly journals A Dual Role for Oncostatin M Signaling in the Differentiation and Death of Mammary Epithelial Cells in Vivo

2008 ◽  
Vol 22 (12) ◽  
pp. 2677-2688 ◽  
Author(s):  
Paul G. Tiffen ◽  
Nader Omidvar ◽  
Nuria Marquez-Almuina ◽  
Dawn Croston ◽  
Christine J. Watson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cell ◽  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Oncostatin M ◽  
Specific Gene ◽  
Mammary Involution

Abstract Recent studies in breast cancer cell lines have shown that oncostatin M (OSM) not only inhibits proliferation but also promotes cell detachment and enhances cell motility. In this study, we have looked at the role of OSM signaling in nontransformed mouse mammary epithelial cells in vitro using the KIM-2 mammary epithelial cell line and in vivo using OSM receptor (OSMR)-deficient mice. OSM and its receptor were up-regulated approximately 2 d after the onset of postlactational mammary regression, in response to leukemia inhibitory factor (LIF)-induced signal transducer and activator of transcription-3 (STAT3). This resulted in sustained STAT3 activity, increased epithelial apoptosis, and enhanced clearance of epithelial structures during the remodeling phase of mammary involution. Concurrently, OSM signaling precipitated the dephosphorylation of STAT5 and repressed expression of the milk protein genes β-casein and whey acidic protein (WAP). Similarly, during pregnancy, OSM signaling suppressed β-casein and WAP gene expression. In vitro, OSM but not LIF persistently down-regulated phosphorylated (p)-STAT5, even in the continued presence of prolactin. OSM also promoted the expression of metalloproteinases MMP3, MMP12, and MMP14, which, in vitro, were responsible for OSM-specific apoptosis. Thus, the sequential activation of IL-6-related cytokines during mammary involution culminates in an OSM-dependent repression of epithelial-specific gene expression and the potentiation of epithelial cell extinction mediated, at least in part, by the reciprocal regulation of p-STAT5 and p-STAT3.

scholarly journals Regulatory function of whey acidic protein in the proliferation of mouse mammary epithelial cells in vivo and in vitro

2004 ◽  
Vol 274 (1) ◽  
pp. 31-44 ◽  
Author(s):  
Naoko Nukumi ◽  
Kayoko Ikeda ◽  
Megumi Osawa ◽  
Tokuko Iwamori ◽  
Kunihiko Naito ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Whey Acidic Protein ◽  
Mammary Epithelial ◽  
Acidic Protein ◽  
Regulatory Function

Differential in vitro and in vivo glycosylation of human erythropoietin expressed in adenovirally transduced mouse mammary epithelial cells

2005 ◽  
Vol 1726 (1) ◽  
pp. 48-56 ◽  
Author(s):  
Jorge R. Toledo ◽  
Oliberto Sánchez ◽  
Raquel Montesino Seguí ◽  
Yaiza Fernández García ◽  
María P. Rodríguez ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Human Erythropoietin

Adenoviral-mediated gene transfer into primary human and mouse mammary epithelial cells in vitro and in vivo

1995 ◽  
Vol 98 (1) ◽  
pp. 9-17 ◽  
Author(s):  
Jason Yang ◽  
Tetsuya Tsukamoto ◽  
Nikolay Popnikolov ◽  
Raphael C. Guzman ◽  
Xiaoyan Chen ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Human And Mouse

cAMP levels in proliferating rat mammary epithelial cells in vitro and in vivo

1989 ◽  
Vol 182 (2) ◽  
pp. 653-658 ◽  
Author(s):  
Stephen P. Ethier ◽  
Rochelle M. Van De Velde ◽  
Kimberly C. Cundiff
Keyword(s):  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Camp Levels
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