Absorption, Pharmacokinetics, and Urinary Excretion of Pyridines After Consumption of Coffee and Cocoa‐Based Products Containing Coffee in a Repeated Dose, Crossover Human Intervention Study

2020 ◽  
Vol 64 (18) ◽  
pp. 2000489 ◽  
Author(s):  
Letizia Bresciani ◽  
Michele Tassotti ◽  
Alice Rosi ◽  
Daniela Martini ◽  
Monica Antonini ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Intervention Study ◽  
Repeated Dose ◽  
Human Intervention ◽  
Human Intervention Study

Urinary Excretion of Anthocyanins Following Consumption of Strawberry and Red Grape Juice

2019 ◽  
Vol 89 (1-2) ◽  
pp. 29-36 ◽  
Author(s):  
Yana Cahyana ◽  
Michael H. Gordon ◽  
Trevor M. Gibson
Keyword(s):  
Urinary Excretion ◽  
Intervention Study ◽  
Grape Juice ◽  
Human Intervention ◽  
Red Grapes ◽  
Human Intervention Study ◽  
Red Grape Juice ◽  
Red Grape

Abstract. The excretion of anthocyanins in urine following consumption of a mixed juice prepared from strawberry and red grape juice was investigated in a human intervention study. Unmetabolised anthocyanins, and glucuronide derivatives have been detected, with pelargonidin-3 glucoside metabolised into pelargonidin monoglucuronide and pelargonidin-3-glucoside monoglucuronide. The mass of urinary anthocyanins excreted in 24 h following consumption of the mixed juice (containing 21.93 mg of anthocyanins) was 144 nmol consisting of 106 nmol of anthocyanins derived from strawberries (0.32% of ingested dose) and 38 nmol derived from red grapes (0.22% of ingested dose). A higher proportion of delphinidin–3-glucoside was excreted in the unmetabolised form than less polar anthocyanins (at p ≤ 0.05). Excretion of anthocyanins peaked between 2 and 4 h following consumption of the juice. The proportion of the ingested anthocyanins excreted was not significantly different for strawberry and red grape anthocyanins despite the differences in the structures.

scholarly journals Perfomance Enhancing Effects Of Ecdysterone- A Human Intervention Study

2019 ◽  
Vol 51 (Supplement) ◽  
pp. 89
Author(s):  
Patrick Diel ◽  
Eduard Isenmann ◽  
Gabriella Ambrosio ◽  
Jan Felix Joseph ◽  
Xavier de la Torre ◽  
...  
Keyword(s):  
Intervention Study ◽  
Human Intervention ◽  
Human Intervention Study

scholarly journals High phosphorus intake and gut-related parameters – results of a randomized placebo-controlled human intervention study

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Ulrike Trautvetter ◽  
Amélia Camarinha-Silva ◽  
Gerhard Jahreis ◽  
Stefan Lorkowski ◽  
Michael Glei
Keyword(s):  
Intervention Study ◽  
Human Intervention ◽  
High Phosphorus ◽  
Human Intervention Study ◽  
Phosphorus Intake

scholarly journals Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study

2010 ◽  
Vol 3 (1) ◽  
Author(s):  
Marjan J van Erk ◽  
Suzan Wopereis ◽  
Carina Rubingh ◽  
Trinette van Vliet ◽  
Elwin Verheij ◽  
...  
Keyword(s):  
Intervention Study ◽  
Human Intervention ◽  
Human Intervention Study

scholarly journals The SYNCAN project: goals, set-up, first results and settings of the human intervention study

2005 ◽  
Vol 93 (S1) ◽  
pp. S91-S98 ◽  
Author(s):  
Jan Van Loo ◽  
Yvonne Clune ◽  
Mary Bennett ◽  
John Kevin Collins
Keyword(s):  
Colon Cancer ◽  
Intervention Study ◽  
Intestinal Flora ◽  
Gastrointestinal Transit ◽  
Synergistic Activity ◽  
Protective Effects ◽  
Human Intervention ◽  
Food Ingredients ◽  
Human Intervention Study

Experimental evidence on the anticancer properties of dietary prebiotics such as chicory inulin and oligofructose and dietary probiotics has accumulated in recent years. Various experimental models ranging from chemoprevention studies, tumour implantation models to genetically modified mice models, etc. have systematically shown the protective effects of these food ingredients. In some studies it appeared that synbiotics (combination of pre- and probiotics) exerted synergistic activity against processes of carcinogenesis. The logical next step in research was to find out if these observations also would be valid for human volunteers. This was the principal goal of the EU-sponsored SYNCAN project (QLK1-1999-346) which involved the integration of an in vitro study to select the most suitable synbiotic preparation, the application of this synbiotic in an in vivo rat model of chemically induced colon cancer, and, as the heart of the project, the investigation of the synbiotic effects in a human intervention study. The in vitro tests consisted of fermentation studies where the interaction of pre- and probiotics was studied. Cell-free supernatants were generated from various synbiotic combinations fermented by faecal slurry, which were then used to optimise a series of bioassays. In the rat study the anticarcinogenic effect of prebiotics and synbiotics but not of probiotics was demonstrated. Using tissue samples generated in this model, attempts were made to gain a better insight into the mechanisms underlying cancer development. The human intervention study consisted of two groups of volunteers. One group was composed of people at high risk (polypectomised subjects) for colon cancer and the other of volunteers (colon cancer subjects) who had previously undergone ‘curative resection‘ for colon cancer but were not currently receiving treatment. The present paper describes the experimental design of the SYNCAN study, and demonstrates a functional effect of the synbiotic preparation (probiotic survival during gastrointestinal transit and modification of the intestinal flora). Detailed experimental outcome of the human intervention study will be reported elsewhere.

Coffee and oxidative stress: a human intervention study

2016 ◽  
Vol 57 (2) ◽  
pp. 533-544 ◽  
Author(s):  
Sergey Shaposhnikov ◽  
Thomas Hatzold ◽  
Naouale El Yamani ◽  
Philip Mark Stavro ◽  
Yolanda Lorenzo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intervention Study ◽  
Human Intervention ◽  
Human Intervention Study ◽  
And Oxidative Stress
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