Metabolomics Reveals Altered Hepatic Bile Acids, Gut Microbiome Metabolites, and Cell Membrane Lipids Associated with Marginal Vitamin A Deficiency in a Mongolian Gerbil Model

2020 ◽  
Vol 64 (13) ◽  
pp. 1901319
Author(s):  
Michael R. La Frano ◽  
Alex Brito ◽  
Catherine M. Johnson ◽  
Baylee Wilhelmson ◽  
Bryan Gannon ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Vitamin A ◽  
Bile Acids ◽  
Mongolian Gerbil ◽  
Gut Microbiome ◽  
Membrane Lipids ◽  
Vitamin A Deficiency ◽  
Hepatic Bile ◽  
Hepatic Bile Acids

Intestinal MiR194 Regulates Hepatic Bile Acids through Intestinal FXR‐FGF15 Pathway in Alcoholic Liver Disease in Mice

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Mengwei Jiang ◽  
Yunhuan Liu ◽  
Zelin Gu ◽  
Fengyuan Li ◽  
Lihua Zhang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Bile Acids ◽  
Alcoholic Liver Disease ◽  
Hepatic Bile ◽  
Hepatic Bile Acids

The inhibition of hepatic bile acids transporters Ntcp and Bsep is involved in the pathogenesis of isoniazid/rifampicin-induced hepatotoxicity

2015 ◽  
Vol 25 (5) ◽  
pp. 382-387 ◽  
Author(s):  
Yao Xue Guo ◽  
Xue Fei Xu ◽  
Qi Zhi Zhang ◽  
Chun Li ◽  
Ye Deng ◽  
...  
Keyword(s):  
Bile Acids ◽  
Hepatic Bile ◽  
Hepatic Bile Acids

Uteroplacental Insufficiency Impairs Cholesterol Elimination in Adult Female Growth-Restricted Rat Offspring Fed a High-Fat Diet

2018 ◽  
Vol 26 (9) ◽  
pp. 1173-1180 ◽  
Author(s):  
Erin K. Zinkhan ◽  
Baifeng Yu ◽  
Robert McKnight
Keyword(s):  
Young Adult ◽  
Bile Acids ◽  
Adult Female ◽  
High Fat Diet ◽  
Female Rats ◽  
Hepatic Cholesterol ◽  
High Fat ◽  
Hepatic Bile ◽  
Artery Ligation ◽  
Hepatic Bile Acids

Uteroplacental insufficiency (UPI) causes intrauterine growth restriction (IUGR) and increases the risk of hypercholesterolemia and cardiovascular disease, which are leading causes of morbidity and mortality worldwide. Little is known about the mechanism through which UPI increases cholesterol. Hepatic Cholesterol 7 alpha-hydroxylase (Cyp7a1) is the rate-limiting and most highly regulated step of cholesterol catabolism to bile acids. Cholesterol 7 alpha-hydroxylase is regulated by transcription factor liver X receptor α (Lxrα) and by microRNA-122. We previously showed that microRNA-122 inhibition of Cyp7a1 translation decreased cholesterol catabolism to bile acids in female IUGR rats at the time of weaning. We hypothesized that UPI would increase cholesterol and microRNA-122 and decrease Cyp7a1 protein and hepatic bile acids in young adult female IUGR rats. To test our hypothesis, we used a rat model of IUGR induced by bilateral uterine artery ligation. Both control and IUGR offspring were exposed to a maternal high-fat diet from before conception through lactation, and all offspring were weaned to a high-fat diet on postnatal day 21. At postnatal day 60, IUGR female rats had increased total and low-density lipoprotein serum cholesterol and hepatic cholesterol, decreased Lxrα and Cyp7a1 protein, and decreased hepatic bile acids. Hepatic microRNA-122 was not changed by UPI. Our findings suggest that UPI decreased cholesterol catabolism to bile acids in young adult female rats through a mechanism independent of microRNA-122.

scholarly journals Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis

2016 ◽  
Vol 139 (8) ◽  
pp. 1764-1775 ◽  
Author(s):  
Guoxiang Xie ◽  
Xiaoning Wang ◽  
Fengjie Huang ◽  
Aihua Zhao ◽  
Wenlian Chen ◽  
...  
Keyword(s):  
Bile Acids ◽  
Liver Carcinogenesis ◽  
Hepatic Bile ◽  
Hepatic Bile Acids

scholarly journals Hepatic bile acids and bile acid-related gene expression in pregnant and lactating rats

PeerJ ◽  
2013 ◽  
Vol 1 ◽  
pp. e143 ◽  
Author(s):  
Qiong N. Zhu ◽  
Hong M. Xie ◽  
Dan Zhang ◽  
Jie Liu ◽  
Yuan F. Lu
Keyword(s):  
Gene Expression ◽  
Bile Acid ◽  
Bile Acids ◽  
Related Gene ◽  
Hepatic Bile ◽  
Hepatic Bile Acids

scholarly journals CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid

2013 ◽  
Vol 266 (2) ◽  
pp. 245-253 ◽  
Author(s):  
Jie Cheng ◽  
Kristopher W. Krausz ◽  
Feng Li ◽  
Xiaochao Ma ◽  
Frank J. Gonzalez
Keyword(s):  
Bile Acids ◽  
Serum Cholesterol ◽  
Hepatic Bile ◽  
Hepatic Bile Acids
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