Caffeine Upregulates Hepatic Sex Hormone‐Binding Globulin Production by Increasing Adiponectin Through AKT/FOXO1 Pathway in White Adipose Tissue

2020 ◽  
Vol 64 (17) ◽  
pp. 1901253
Author(s):  
Laura Briansó‐Llort ◽  
Lidia Fuertes‐Rioja ◽  
Lorena Ramos‐Perez ◽  
Cristina Hernandez ◽  
Rafael Simó ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

scholarly journals Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women

Obesity ◽  
2013 ◽  
Vol 21 (3) ◽  
pp. 629-636 ◽  
Author(s):  
Rachel P. Wildman ◽  
Dan Wang ◽  
Ivonne Fernandez ◽  
Peter Mancuso ◽  
Nanette Santoro ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Sex Hormone ◽  
Midlife Women ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Tissue Hormones

scholarly journals Contribution of Body Fatness and Adipose Tissue Distribution to the Age Variation in Plasma Steroid Hormone Concentrations in Men: The HERITAGE Family Study*

2000 ◽  
Vol 85 (3) ◽  
pp. 1026-1031 ◽  
Author(s):  
Charles Couillard ◽  
Jacques Gagnon ◽  
Jean Bergeron ◽  
Arthur S. Leon ◽  
D. C. Rao ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Steroid Hormone ◽  
Older Men ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Older Individuals ◽  
Hormone Binding ◽  
Body Fatness ◽  
Hormone Profile ◽  
Age Related

Abstract Obesity has been associated with alterations in plasma steroid hormone concentrations in men. Older men present an altered steroid hormone profile compared to younger individuals, and an increase in body fatness and changes in adipose tissue (AT) distribution are noted with advancing age. Thus, there is a need to examine the relative importance of increased body fatness and changes in AT distribution with advancing age to plasma steroid hormone and sex hormone-binding globulin levels in men. We, therefore, investigated the relationships among age, body fatness, AT distribution, and the plasma steroid hormone profile in a group of 217 Caucasian men (mean age ± sd, 36.2± 14.9 yr) who covered a wide age range (17–64 yr). Compared to young adult men, older men were characterized by increased adiposity (P < 0.0001) expressed either as body mass index or total body fat mass assessed by underwater weighing. Differences in AT distribution were also noted with a preferential accumulation of abdominal fat as indicated by a larger waist girth (P < 0.0001) and higher visceral AT accumulation (P < 0.0001), measured by computed tomography, in older subjects. Age was associated with decreases (P < 0.0001) in C19 adrenal steroid levels, namely reduced dehydroepiandrosterone (DHEA), DHEA fatty acid ester, DHEA sulfate, as well as androstenedione levels. Androgens, i.e. dihydrotestosterone and testosterone, were also affected by age, with lower levels of both steroids being found in older individuals (P < 0.0005). When statistical adjustment for body fatness and AT distribution was performed, differences in C19 adrenal steroids between the age groups remained significant, whereas differences in androgens and sex hormone-binding globulin concentrations were no longer significant. The present study suggests that age-related differences in plasma steroid hormone levels, especially androgens, are partly mediated by concomitant variation in adiposity in men.

scholarly journals Associations of Testosterone and Sex Hormone Binding Globulin with Adipose Tissue Hormones in Midlife Women

Obesity ◽  
2012 ◽  
Author(s):  
Rachel P. Wildman ◽  
Dan Wang ◽  
Ivonne Fernandez ◽  
Peter Mancuso ◽  
Nanette Santoro ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Sex Hormone ◽  
Midlife Women ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Tissue Hormones

Effects of oestradiol on sex hormone binding globulin

1982 ◽  
Vol 101 (2) ◽  
pp. 248-253 ◽  
Author(s):  
Viveca Odlind ◽  
Kerstin Elamsson ◽  
Doris E. Englund ◽  
Arne Victor ◽  
Elof D. B. Johansson
Keyword(s):  
Luteal Phase ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Pronounced Increase ◽  
Menstrual Cycles ◽  
Menopausal Women ◽  
Plasma Oestradiol

Abstract. Sex hormone binding globulin (SHBG) levels were studied for possible effects of oestradiol-17β on SHBG. No change in SHBG plasma was recorded during normal menstrual cycles or during treatment with oestradiol-17β to menopausal women. However, gonadotrophin treatment to amenorrhoeic women to induce ovulation resulted in high oestradiol concentrations and a pronounced increase in SHBG was found during the luteal phase of these cycles. A marked increase of SHBG was also recorded in a woman with pronounced fluctuations of oestradiol during treatment with levonorgestrel sc implants for contraception. In conclusion, effects on SHBG were only found when extraordinarily high levels of plasma oestradiol were recorded.

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