Epigenetics Predicts Serum 25‐Hydroxyvitamin D Response to Vitamin D 3 Supplementation in African Americans

2019 ◽  
Vol 64 (1) ◽  
pp. 1900738
Author(s):  
Li Chen ◽  
Yanbin Dong ◽  
Jie Chen ◽  
Ying Huang ◽  
Haidong Zhu
Keyword(s):  
Vitamin D ◽  
African Americans ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Vitamin D 3

scholarly journals Common Variation in Vitamin D Pathway Genes Predicts Circulating 25-Hydroxyvitamin D Levels among African Americans

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e28623 ◽  
Author(s):  
Lisa B. Signorello ◽  
Jiajun Shi ◽  
Qiuyin Cai ◽  
Wei Zheng ◽  
Scott M. Williams ◽  
...  
Keyword(s):  
Vitamin D ◽  
African Americans ◽  
Common Variation ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Molecular cloning of 25-hydroxyvitamin D-3 24-hydroxylase (Cyp-24) from mouse kidney: its inducibility by vitamin D-3

1995 ◽  
Vol 1264 (1) ◽  
pp. 26-28 ◽  
Author(s):  
Susumu Itoh ◽  
Takuya Yoshimura ◽  
Osamu Iemura ◽  
Eitaro Yamada ◽  
Kazutake Tsujikawa ◽  
...  
Keyword(s):  
Vitamin D ◽  
Molecular Cloning ◽  
Mouse Kidney ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Vitamin D 3

scholarly journals Does the High Prevalence of Vitamin D Deficiency in African Americans Contribute to Health Disparities?

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 499
Author(s):  
Bruce N. Ames ◽  
William B. Grant ◽  
Walter C. Willett
Keyword(s):  
Vitamin D ◽  
African Americans ◽  
Vitamin D Deficiency ◽  
High Latitudes ◽  
Uvb Radiation ◽  
Vitamin D Status ◽  
Dark Skin ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Tract Infections

African Americans have higher incidence of, and mortality from, many health-related problems than European Americans. They also have a 15 to 20-fold higher prevalence of severe vitamin D deficiency. Here we summarize evidence that: (i) this health disparity is partly due to insufficient vitamin D production, caused by melanin in the skin blocking the UVB solar radiation necessary for its synthesis; (ii) the vitamin D insufficiency is exacerbated at high latitudes because of the combination of dark skin color with lower UVB radiation levels; and (iii) the health of individuals with dark skin can be markedly improved by correcting deficiency and achieving an optimal vitamin D status, as could be obtained by supplementation and/or fortification. Moderate-to-strong evidence exists that high 25-hydroxyvitamin D levels and/or vitamin D supplementation reduces risk for many adverse health outcomes including all-cause mortality rate, adverse pregnancy and birth outcomes, cancer, diabetes mellitus, Alzheimer’s disease and dementia, multiple sclerosis, acute respiratory tract infections, COVID-19, asthma exacerbations, rickets, and osteomalacia. We suggest that people with low vitamin D status, which would include most people with dark skin living at high latitudes, along with their health care provider, consider taking vitamin D3 supplements to raise serum 25-hydroxyvitamin D levels to 30 ng/mL (75 nmol/L) or possibly higher.

scholarly journals Effects of vitamin D supplementation on depression in patients with colorectal cancer

2020 ◽  
Author(s):  
JianWen Duan ◽  
YongSheng Chen ◽  
WenFei Wu ◽  
Cong Xiong ◽  
ZuLiang Hu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Vitamin D3 ◽  
Rating Scale ◽  
Vitamin D Supplementation ◽  
Hydroxyvitamin D ◽  
Vitamin D3 Supplementation ◽  
Healthy Control ◽  
25 Hydroxyvitamin D ◽  
Vitamin D 3

Abstract Background: The relation and possible mechnism of vitamin D supplementation on depression in colorectal cancer (CRC) patients was not clearly ; Objective: This study investigates the effect of vitamin D supplementation on depression in colorectal cancer (CRC) patients. Methods : We recruited 168 CRC patients and 168 healthy control subjects into this study. 17-item Hamilton Depression Rating Scale (HDRS-17) was used to assess depression. Results: We found that 25-hydroxyvitamin D (25(OH)D) concentrations were independently associated with depression among CRC patients. For the 45 depressed patients receiving vitamin D3 supplementation, depression scores decreased markedly with 25(OH)D concentrations increasing to normal. Conclusion: Therefore, we advise monitoring this indicator in CRC patients and supplementing with vitamin D 3 when their 25(OH)D concentrations are low.

Plasma concentrations of 25-hydroxyvitamin D in meat eaters, fish eaters, vegetarians and vegans: results from the EPIC–Oxford study

2010 ◽  
Vol 14 (2) ◽  
pp. 340-346 ◽  
Author(s):  
Francesca L Crowe ◽  
Marinka Steur ◽  
Naomi E Allen ◽  
Paul N Appleby ◽  
Ruth C Travis ◽  
...  
Keyword(s):  
Vitamin D ◽  
Plasma Concentrations ◽  
White Men ◽  
Food Sources ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Animal Product ◽  
25 Hydroxyvitamin D ◽  
Vitamin D 3 ◽  
Sectional Analysis

AbstractObjectiveVegetarians and vegans exclude certain food sources of vitamin D from their diet, but it is not clear to what extent this affects plasma concentrations of 25-hydroxyvitamin D (25(OH)D). The objective was to investigate differences in vitamin D intake and plasma concentrations of 25(OH)D among meat eaters, fish eaters, vegetarians and vegans.DesignA cross-sectional analysis.SettingUnited Kingdom.SubjectsPlasma 25(OH)D concentrations were measured in 2107 white men and women (1388 meat eaters, 210 fish eaters, 420 vegetarians and eighty-nine vegans) aged 20–76 years from the European Prospective Investigation into Cancer and Nutrition (EPIC)–Oxford cohort.ResultsPlasma 25(OH)D concentrations reflected the degree of animal product exclusion and, hence, dietary intake of vitamin D; meat eaters had the highest mean intake of vitamin D (3·1 (95 % CI 3·0, 3·2) μg/d) and mean plasma 25(OH)D concentrations (77·0 (95 % CI 75·4, 78·8) nmol/l) and vegans the lowest (0·7 (95 % CI 0·6, 0·8) μg/d and 55·8 (95 % CI 51·0, 61·0) nmol/l, respectively). The magnitude of difference in 25(OH)D concentrations between meat eaters and vegans was smaller (20 %) among those participants who had a blood sample collected during the summer months (July–September) compared with the winter months (38 %; January–March). The prevalence of low plasma concentrations of 25(OH)D (<25 nmol/l) during the winter and spring ranged from <1 % to 8 % across the diet groups.ConclusionsPlasma 25(OH)D concentrations were lower in vegetarians and vegans than in meat and fish eaters; diet is an important determinant of plasma 25(OH)D in this British population.

Depressed Serum 25-Hydroxyvitamin D Levels Increase Hospital Stay and Alter Glucose Homeostasis in First-ever Ischemic Stroke

2019 ◽  
Vol 16 (4) ◽  
pp. 340-347
Author(s):  
Yuge Wang ◽  
Yanqiang Wang ◽  
Bingjun Zhang ◽  
Yinyao Lin ◽  
Sha Tan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Ischemic Stroke ◽  
Hospital Stay ◽  
Functional Outcome ◽  
Vitamin D Deficiency ◽  
Glucose Homeostasis ◽  
Clinical Severity ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Deficiency Group

Background and Objective: Vitamin D deficiency is internationally recognized among the potentially modifiable risk factors for ischemic cardio-cerebrovascular diseases. However, the association between vitamin D deficiency and stroke morbidity or mortality remains insufficiently known. Our aim is to investigate their relevance to 25-hydroxyvitamin D [25(OH) D] levels and clinical severity and outcome after 3 months in first-ever ischemic stroke. Methods: Retrospective analysis of 356 consecutive patients in first-ever ischemic stroke between 2013 and 2015. Serum 25(OH) D levels were measured at baseline. Stroke severity was assessed at admission using the National Institutes of Health Stroke Scale (NIHSS) score. Functional outcome after 3 months of onset was evaluated using the modified Rankin scale (mRS). Results: Among the 356 enrolled patients, HbA1c was higher in insufficiency/deficiency group than that in the sufficiency group (6.3 ± 1.7 vs. 5.9 ± 1.1, p =0.015). The hospital stay was longer in insufficiency/deficiency group than that in the sufficiency group (11 (8-17) vs. 9.5 (7-13), p = 0.035). There was a significant inversed trend between serum 25(OH) D levels and hospital stay (OR 0.960, P = 0.031), using logistic regression. Conclusions: 25(OH)D levels are associated with glucose homeostasis, 25(OH) D contributes to increase the length of hospital stay. Low serum 25-OHD level is an independent predictor for hospital stay in first-ever ischemic stroke. Vitamin D deficiency did not predict functional outcome in the span of 3 months.

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