Identification and Peptidomic Profiling of Exosomes in Preterm Human Milk: Insights Into Necrotizing Enterocolitis Prevention

2019 ◽  
pp. 1801247 ◽  
Author(s):  
Xingyun Wang ◽  
Xiangyun Yan ◽  
Le Zhang ◽  
Jinyang Cai ◽  
Yahui Zhou ◽  
...  
Keyword(s):  
Human Milk ◽  
Necrotizing Enterocolitis ◽  
Peptidomic Profiling

Dr. Barness Replies

PEDIATRICS ◽  
1977 ◽  
Vol 60 (4) ◽  
pp. 560-561
Author(s):  
LEWIS A. BARNESS
Keyword(s):  
Human Milk ◽  
Necrotizing Enterocolitis ◽  
Clinical Evidence ◽  
Bacterial Flora

Dr. Ainbender et al. are correct in questioning the clinical evidence indicating that human milk provides protection from necrotizing enterocolitis. We would be very interested in seeing their publication, which apparently is in conflict with many others, e.g., those of Gyorgy1 and Winberg and Wessner,2 regarding gastrointestinal bacterial flora.

scholarly journals Human milk oligosaccharides prevent Necrotizing Enterocolitis in neonatal rats

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Lars Bode ◽  
Kerstin Goth ◽  
Yigit Guner ◽  
Caroline Nissan ◽  
Monica Zherebtsov ◽  
...  
Keyword(s):  
Human Milk ◽  
Necrotizing Enterocolitis ◽  
Neonatal Rats ◽  
Human Milk Oligosaccharides ◽  
Milk Oligosaccharides

Feeding the feeble

2021 ◽  
pp. 265-272
Author(s):  
Michael Obladen
Keyword(s):  
Human Milk ◽  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Premature Infants ◽  
Tube Feeding ◽  
Theoretical Knowledge ◽  
Air Inlet ◽  
Nasogastric Tubes ◽  
Nutritional Needs ◽  
The 1960S

This chapter describes historic steps in feeding techniques and knowledge about the nutritional needs of premature infants. Devices to overcome weak sucking and swallowing were developed from 1851 to 1920: tube feeding by gavage, medicine droppers and pipettes, feeding bottles with air inlet, and beaked spoons for nasal feeding. Indwelling nasogastric tubes were in use from 1951. For alleged safety concerns, postnatal feeding was postponed until a week of starvation was reached in the 1950s and studies showed an association with neurological handicaps. The premature infant’s elevated need for energy, protein, and minerals has been known since 1919. However, nutritional practice lagged behind theoretical knowledge. Concentrated formula was developed in the 1940s, parenteral supplementation in the 1960s, and human milk fortifiers in the 1970s. In the 1990s, necrotizing enterocolitis was found to be more frequent in infants fed formula than in those fed human milk. Recently, probiotics were shown to reduce the risk of necrotizing enterocolitis. Compared to other aspects of neonatal medicine, there is little evidence on how to feed preterm infants.

scholarly journals Role of human milk in extremely low birth weight infants’ risk of necrotizing enterocolitis or death

2008 ◽  
Vol 29 (1) ◽  
pp. 57-62 ◽  
Author(s):  
J Meinzen-Derr ◽  
◽  
B Poindexter ◽  
L Wrage ◽  
A L Morrow ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Necrotizing Enterocolitis ◽  
Extremely Low Birth Weight ◽  
Low Birth Weight Infants

scholarly journals Reduced Necrotizing Enterocolitis after an Initiative to Promote Breastfeeding and Early Human Milk Administration

2017 ◽  
Vol 2 (2) ◽  
pp. e014 ◽  
Author(s):  
Michelle Feinberg ◽  
Lynn Miller ◽  
Barbara Engers ◽  
Kathy Bigelow ◽  
Ann Lewis ◽  
...  
Keyword(s):  
Human Milk ◽  
Necrotizing Enterocolitis ◽  
Early Human

Necrotizing enterocolitis and human milk

1979 ◽  
Vol 94 (2) ◽  
pp. 295-296 ◽  
Author(s):  
R.R. Moriartey ◽  
N.N. Finer ◽  
S.F. Cox ◽  
H.J. Phillips ◽  
A. Theman ◽  
...  
Keyword(s):  
Human Milk ◽  
Necrotizing Enterocolitis

scholarly journals The Role of Human Milk Oligosaccharides and Probiotics on the Neonatal Microbiome and Risk of Necrotizing Enterocolitis: A Narrative Review

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3052
Author(s):  
Lila S. Nolan ◽  
Jamie M. Rimer ◽  
Misty Good
Keyword(s):  
Human Milk ◽  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Mode Of Delivery ◽  
Intestinal Barrier ◽  
Vulnerable Population ◽  
Human Milk Oligosaccharides ◽  
Milk Oligosaccharides ◽  
Intestinal Homeostasis

Preterm infants are a vulnerable population at risk of intestinal dysbiosis. The newborn microbiome is dominated by Bifidobacterium species, though abnormal microbial colonization can occur by exogenous factors such as mode of delivery, formula feeding, and exposure to antibiotics. Therefore, preterm infants are predisposed to sepsis and necrotizing enterocolitis (NEC), a fatal gastrointestinal disorder, due to an impaired intestinal barrier, immature immunity, and a dysbiotic gut microbiome. Properties of human milk serve as protection in the prevention of NEC. Human milk oligosaccharides (HMOs) and the microbiome of breast milk are immunomodulatory components that provide intestinal homeostasis through regulation of the microbiome and protection of the intestinal barrier. Enteral probiotic supplements have been trialed to evaluate their impact on establishing intestinal homeostasis. Here, we review the protective role of HMOs, probiotics, and synbiotic combinations in protecting a vulnerable population from the pathogenic features associated with necrotizing enterocolitis.

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