scholarly journals Serum Omega‐6 Fatty Acids and Immunology‐Related Gene Expression in Peripheral Blood Mononuclear Cells: A Cross‐Sectional Analysis in Healthy Children

2019 ◽  
Vol 63 (7) ◽  
pp. 1800990
Author(s):  
Jacob J. Christensen ◽  
Siril S. Bakke ◽  
Stine M. Ulven ◽  
Kjetil Retterstøl ◽  
Tore Henriksen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Mononuclear Cells ◽  
Healthy Children ◽  
Related Gene ◽  
Peripheral Blood Mononuclear ◽  
Cross Sectional ◽  
Blood Mononuclear Cells ◽  
Omega 6 ◽  
Sectional Analysis

scholarly journals Effects of fish and krill oil on gene expression in peripheral blood mononuclear cells and circulating markers of inflammation: a randomised controlled trial

2018 ◽  
Vol 7 ◽  
Author(s):  
Amanda Rundblad ◽  
Kirsten B. Holven ◽  
Inge Bruheim ◽  
Mari C. Myhrstad ◽  
Stine M. Ulven
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Mrna Expression ◽  
Inflammatory Markers ◽  
Mononuclear Cells ◽  
Krill Oil ◽  
Fatty Fish ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Circulating Inflammatory Markers

AbstractMarine n-3 (omega-3) fatty acids alter gene expression by regulating the activity of transcription factors. Krill oil is a source of marine n-3 fatty acids that has been shown to modulate gene expression in animal studies; however, the effect in humans is not known. Hence, we aimed to compare the effect of intake of krill oil, lean and fatty fish with a similar content of n-3 fatty acids, and high-oleic sunflower oil (HOSO) with added astaxanthin on the expression of genes involved in glucose and lipid metabolism and inflammation in peripheral blood mononuclear cells (PBMC) as well as circulating inflammatory markers. In an 8-week trial, healthy men and women aged 18–70 years with fasting TAG of 1·3–4·0 mmol/l were randomised to receive krill oil capsules (n 12), HOSO capsules (n 12) or lean and fatty fish (n 12). The weekly intakes of marine n-3 fatty acids from the interventions were 4654, 0 and 4103 mg, respectively. The mRNA expression of four genes, PPAR γ coactivator 1A (PPARGC1A), steaoryl-CoA desaturase (SCD), ATP binding cassette A1 (ABCA1) and cluster of differentiation 40 (CD40), were differently altered by the interventions. Furthermore, within-group analyses revealed that krill oil down-regulated the mRNA expression of thirteen genes, including genes involved in glucose and cholesterol metabolism and β-oxidation. Fish altered the mRNA expression of four genes and HOSO down-regulated sixteen genes, including several inflammation-related genes. There were no differences between the groups in circulating inflammatory markers after the intervention. In conclusion, the intake of krill oil and HOSO with added astaxanthin alter the PBMC mRNA expression of more genes than the intake of fish.

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