The Immunomodulatory Properties of Propyl-Propane Thiosulfonate Contribute to its Intestinal Anti-Inflammatory Effect in Experimental Colitis

2019 ◽  
Vol 63 (5) ◽  
pp. 1800653 ◽  
Author(s):  
Teresa Vezza ◽  
Francesca Algieri ◽  
José Garrido-Mesa ◽  
María Pilar Utrilla ◽  
María Elena Rodríguez-Cabezas ◽  
...  
Keyword(s):  
Experimental Colitis ◽  
Immunomodulatory Properties ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Effect of a Milk-Based Fruit Beverage Enriched with Plant Sterols and/or Galactooligosaccharides in a Murine Chronic Colitis Model

Foods ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 114 ◽  
Author(s):  
Gabriel López-García ◽  
Antonio Cilla ◽  
Reyes Barberá ◽  
Amparo Alegría ◽  
María Recio
Keyword(s):  
Ulcerative Colitis ◽  
Experimental Colitis ◽  
Plant Sterols ◽  
Mice Model ◽  
Colon Tissue ◽  
Clinical Model ◽  
Need To Evaluate ◽  
Anti Inflammatory ◽  
Enriched Milk ◽  
Inflammatory Effect

The potential anti-inflammatory effect of plant sterols (PS) enriched milk-based fruit beverages (PS, 1 g/100 mL) (MfB) with/without galactooligosaccharides (GOS, 2 g/100 mL) (MfB-G) in an experimental mice model of chronic ulcerative colitis was evaluated. Beverages were orally administered to mice every day by gavage to achieve PS and GOS doses of 35 and 90 mg/kg, respectively, and experimental colitis was induced by giving mice drinking water ad libitum containing 2% (w/v) dextran sulphate sodium (DSS) for 7 days, alternating with periods without DSS up to the end of the study (56 days). MfB beverage showed significant reduction of symptoms associated to ulcerative colitis and improved the colon shortening and mucosal colonic damage, but it was not able to reduce the increase of myeloperoxidase levels produced by DSS. MfB-G showed higher incidence of bloody feces and loss of stool consistency than MfB, as well as high levels of immune cells infiltration in colon tissue and myeloperoxidase. Therefore, PS-enriched milk-based fruit beverage could be an interesting healthy food to extend the remission periods of the diseases and the need to evaluate, in a pre-clinical model, the anti-inflammatory effect of the combination of bioactive compounds in the context of a whole food matrix.

scholarly journals Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity

2020 ◽  
Vol 9 (9) ◽  
pp. 2913
Author(s):  
Ji Yeon Kang ◽  
Mi-Kyung Oh ◽  
Hansol Joo ◽  
Hyun Sung Park ◽  
Dong-Hoon Chae ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Experimental Colitis ◽  
Wharton’S Jelly ◽  
Differentiation Potential ◽  
Hematopoietic Stem ◽  
Wharton's Jelly ◽  
Indoleamine 2,3 Dioxygenase ◽  
Immunomodulatory Properties ◽  
Anti Inflammatory

The therapeutic applications of mesenchymal stem cells (MSCs) have been actively explored due to their broad anti-inflammatory and immunomodulatory properties. However, the use of xenogeneic components, including fetal bovine serum (FBS), in the expansion media might pose a risk of xenoimmunization and zoonotic transmission to post-transplanted patients. Here, we extensively compared the physiological functions of human Wharton’s jelly-derived MSCs (WJ-MSCs) in a xeno-free medium (XF-MSCs) and a medium containing 10% FBS (10%-MSCs). Both groups showed similar proliferation potential; however, the 10%-MSCs showed prolonged expression of CD146, with higher colony-forming unit-fibroblast (CFU-F) ability than the XF-MSCs. The XF-MSCs showed enhanced adipogenic differentiation potential and sufficient hematopoietic stem cell (HSC) niche activity, with elevated niche-related markers including CXCL12. Furthermore, we demonstrated that the XF-MSCs had a significantly higher suppressive effect on human peripheral blood-derived T cell proliferation, Th1 and Th17 differentiation, as well as naïve macrophage polarization toward an M1 phenotype. Among the anti-inflammatory molecules, the production of indoleamine 2,3-dioxygenase (IDO) and nitric oxide synthase 2 (NOS2) was profoundly increased, whereas cyclooxygenase-2 (COX-2) was decreased in the XF-MSCs. Finally, the XF-MSCs had an enhanced therapeutic effect against mouse experimental colitis. These findings indicate that xeno-free culture conditions improved the immunomodulatory properties of WJ-MSCs and ex vivo-expanded XF-MSCs might be an effective strategy for preventing the progression of colitis.

scholarly journals Helicobacter pyloriDNA's anti-inflammatory effect on experimental colitis

Gut Microbes ◽  
2012 ◽  
Vol 3 (2) ◽  
pp. 168-171 ◽  
Author(s):  
Stephanie Y. Owyang ◽  
Jay Luther ◽  
Christopher C. Owyang ◽  
Min Zhang ◽  
John Y. Kao
Keyword(s):  
Experimental Colitis ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Anti-inflammatory effect of acute stress on experimental colitis is mediated by cholecystokinin-B receptors

Life Sciences ◽  
2004 ◽  
Vol 75 (1) ◽  
pp. 77-91 ◽  
Author(s):  
Mehmet Ali Gülpınar ◽  
Dilek Özbeyli ◽  
Serap Arbak ◽  
Berrak Ç Yeğen
Keyword(s):  
Acute Stress ◽  
Experimental Colitis ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis

Microbiome ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Zhenhua Wu ◽  
Shimeng Huang ◽  
Tiantian Li ◽  
Na Li ◽  
Dandan Han ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Green Tea ◽  
Fecal Microbiota Transplantation ◽  
Experimental Colitis ◽  
Short Chain Fatty Acids ◽  
Dependent Manner ◽  
Barrier Integrity ◽  
Green Tea Polyphenol ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Abstract Background Alteration of the gut microbiota may contribute to the development of inflammatory bowel disease (IBD). Epigallocatechin-3-gallate (EGCG), a major bioactive constituent of green tea, is known to be beneficial in IBD alleviation. However, it is unclear whether the gut microbiota exerts an effect when EGCG attenuates IBD. Results We first explored the effect of oral or rectal EGCG delivery on the DSS-induced murine colitis. Our results revealed that anti-inflammatory effect and colonic barrier integrity were enhanced by oral, but not rectal, EGCG. We observed a distinct EGCG-mediated alteration in the gut microbiome by increasing Akkermansia abundance and butyrate production. Next, we demonstrated that the EGCG pre-supplementation induced similar beneficial outcomes to oral EGCG administration. Prophylactic EGCG attenuated colitis and significantly enriched short-chain fatty acids (SCFAs)-producing bacteria such as Akkermansia and SCFAs production in DSS-induced mice. To validate these discoveries, we performed fecal microbiota transplantation (FMT) and sterile fecal filtrate (SFF) to inoculate DSS-treated mice. Microbiota from EGCG-dosed mice alleviated the colitis over microbiota from control mice and SFF shown by superiorly anti-inflammatory effect and colonic barrier integrity, and also enriched bacteria such as Akkermansia and SCFAs. Collectively, the attenuation of colitis by oral EGCG suggests an intimate involvement of SCFAs-producing bacteria Akkermansia, and SCFAs, which was further demonstrated by prophylaxis and FMT. Conclusions This study provides the first data indicating that oral EGCG ameliorated the colonic inflammation in a gut microbiota-dependent manner. Our findings provide novel insights into EGCG-mediated remission of IBD and EGCG as a potential modulator for gut microbiota to prevent and treat IBD.

scholarly journals Curcuma longa Extract Exerts a Myorelaxant Effect on the Ileum and Colon in a Mouse Experimental Colitis Model, Independent of the Anti-Inflammatory Effect

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e44650 ◽  
Author(s):  
Rita Aldini ◽  
Roberta Budriesi ◽  
Giulia Roda ◽  
Matteo Micucci ◽  
Pierfranco Ioan ◽  
...  
Keyword(s):  
Curcuma Longa ◽  
Experimental Colitis ◽  
Model Independent ◽  
Anti Inflammatory ◽  
Colitis Model ◽  
Inflammatory Effect

scholarly journals Anti-inflammatory effect of Chang-An-Shuan on TNBS-induced experimental colitis in rats

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Hong Mi ◽  
Feng-bin Liu ◽  
Hai-wen Li ◽  
Jiang-tao Hou ◽  
Pei-wu Li
Keyword(s):  
Experimental Colitis ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The intestinal anti-inflammatory effect of minocycline in experimental colitis involves both its immunomodulatory and antimicrobial properties

2011 ◽  
Vol 63 (4) ◽  
pp. 308-319 ◽  
Author(s):  
Natividad Garrido-Mesa ◽  
Desirée Camuesco ◽  
Belén Arribas ◽  
Mònica Comalada ◽  
Elvira Bailón ◽  
...  
Keyword(s):  
Antimicrobial Properties ◽  
Experimental Colitis ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Anti-inflammatory effect of novel analogs of natural enkephalinase inhibitors in a mouse model of experimental colitis

2016 ◽  
Vol 8 (18) ◽  
pp. 2231-2243 ◽  
Author(s):  
Elżbieta Kamysz ◽  
Maciej Sałaga ◽  
Małgorzata Sobocińska ◽  
Artur Giełdoń ◽  
Jakub Fichna
Keyword(s):  
Mouse Model ◽  
Experimental Colitis ◽  
Anti Inflammatory ◽  
Enkephalinase Inhibitors ◽  
Inflammatory Effect
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