Regulatory Efficacy of Brown Seaweed Lessonia nigrescens Extract on the Gene Expression Profile and Intestinal Microflora in Type 2 Diabetic Mice

2018 ◽  
Vol 62 (4) ◽  
pp. 1700730 ◽  
Author(s):  
Chao Zhao ◽  
Chengfeng Yang ◽  
Mingjun Chen ◽  
Xucong Lv ◽  
Bin Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Intestinal Microflora ◽  
Brown Seaweed ◽  
Diabetic Mice ◽  
Lessonia Nigrescens ◽  
Type 2 Diabetic

scholarly journals Gene Expression Profile Analysis of Type 2 Diabetic Mouse Liver

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e57766 ◽  
Author(s):  
Fang Zhang ◽  
Xiang Xu ◽  
Yi Zhang ◽  
Ben Zhou ◽  
Zhishui He ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Mouse Liver ◽  
Profile Analysis ◽  
Diabetic Mouse ◽  
Expression Profile Analysis ◽  
Type 2 Diabetic

Gene expression profile in leucocytes of type 2 diabetic subjects

2009 ◽  
Vol 20 (3) ◽  
pp. 158 ◽  
Author(s):  
S Muniandy ◽  
R Qvist ◽  
IS Ismail ◽  
S Kaviarasan
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Type 2 Diabetic

scholarly journals Reducing effect of insulin resistance on alpha-synuclein gene expression in skeletal muscle

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Amirhosein Khoshi ◽  
Golnaz Goodarzi ◽  
Rezvan Mohammadi ◽  
Roghaye Arezumand ◽  
Meysam Moghbeli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Insulin Resistance ◽  
Glucose Uptake ◽  
Alpha Synuclein ◽  
C2c12 Cells ◽  
Diabetic Mice ◽  
Insulin Metabolism ◽  
Insulin Resistant ◽  
Type 2 Diabetic

Abstract Background Alpha-synuclein (SNCA) as the presynaptic protein is expressed in different tissues and prevents insulin-resistance (IR) through increasing glucose-uptake by adipocytes and muscles. However, the effect of insulin metabolism on SNCA expression has scarcely elucidated. In present study we assessed the probable effect of insulin resistance on SNCA expression in muscle C2C12 cells and also skeletal muscle tissues of type 2 diabetic mice. Materials and methods Sixteen male C57BL/6 mice were divided into two experimental groups, including control and type 2 diabetic mice with IR (induced by high-fat diet + low-dose streptozotocin). The animals of the study involved the measurements of fasting blood glucose, oral-glucose-tolerance-test, as well as fasting plasma insulin. Moreover, insulin-resistant and insulin-sensitive muscle C2C12 cells were prepared. The insulin-resistance was confirmed by the glucose-uptake assay. Comparative quantitative real time PCR was used to assess the SNCA expression. Results The obtained results have showed a significant ~ 27% decrease in SNCA expression level in muscle tissue of diabetic mice (P = 0.022). Moreover, there was a significant change of SNCA expression in insulin-resistant C2C12 cells (P < 0.001). Conclusion Type 2 diabetes due to insulin-resistance can decrease SNCA gene expression in muscles. In addition to the role of SNCA in cell susceptibility to insulin and glucose uptake, the SNCA expression can also be affected by insulin metabolism.

scholarly journals Gene expression profile in streptozotocin-induced diabetic mice kidneys undergoing glomerulosclerosis

2001 ◽  
Vol 59 (4) ◽  
pp. 1363-1373 ◽  
Author(s):  
Jun Wada ◽  
Hong Zhang ◽  
Yoshinori Tsuchiyama ◽  
Keita Hiragushi ◽  
Kazuyuki Hida ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Diabetic Mice

scholarly journals Gene Expression Profile in Skeletal Muscle of Type 2 Diabetes and the Effect of Insulin Treatment

Diabetes ◽  
2002 ◽  
Vol 51 (6) ◽  
pp. 1913-1920 ◽  
Author(s):  
R. Sreekumar ◽  
P. Halvatsiotis ◽  
J. C. Schimke ◽  
K. S. Nair
Keyword(s):  
Gene Expression ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Insulin Treatment

scholarly journals Role of Green Macroalgae Enteromorpha Prolifera Polyphenols in the Modulation of Gene Expression and Intestinal Microflora Profiles in Type 2 Diabetic Mice

2018 ◽  
Vol 20 (1) ◽  
pp. 25 ◽  
Author(s):  
Guopeng Lin ◽  
Xiaoyan Liu ◽  
Xin Yan ◽  
Dan Liu ◽  
Chengfeng Yang ◽  
...  
Keyword(s):  
Intestinal Microflora ◽  
Fasting Blood Glucose ◽  
Antidiabetic Activity ◽  
Rrna Gene ◽  
Regulation Mechanism ◽  
Diabetic Mice ◽  
Enteromorpha Prolifera ◽  
Green Macroalgae ◽  
Type 2 Diabetic

Effects of green macroalgae 55% ethanolic extract Enteromorpha prolifera through an ultrafiltration membrane of 3 kDa (EPE3k) on antidiabetic activity, gut microbiota, and regulation mechanism were investigated in high-fat/high-sucrose diet and streptozocin-induced diabetic mice. The structural characterizations of its major compounds in EPE3k were determined by ultra-performance liquid chromatography-quadrupole/time of flight mass spectrometry. Furthermore, the intestinal microflora modulation in diabetic mice was also investigated with high-throughput 16S rRNA gene sequencing. The proposed presence of polyphenols in EPE3k was confirmed. EPE3k could significantly decrease the fasting blood glucose and improve fasting glucose tolerance. The hypoglycemic effect of EPE3k was via activation of phosphatidylinositol 3-kinase and suppression of c-Jun N-terminal kinase in liver. EPE3k treatment significantly increased the relative abundance of Akkermansia and decreased the proportion of Alistipes and Turicibacter. The above results indicated that EPE3k could be provided as a new potential therapy for the treatment of type 2 diabetic mellitus.

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