Citrus flavonoid naringenin reduces mammary tumor cell viability, adipose mass, and adipose inflammation in obese ovariectomized mice

2017 ◽  
Vol 61 (9) ◽  
pp. 1600934 ◽  
Author(s):  
Jia-Yu Ke ◽  
Taylor Banh ◽  
Yung-Hsuan Hsiao ◽  
Rachel M. Cole ◽  
Shana R. Straka ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Viability ◽  
Mammary Tumor ◽  
Mammary Tumor Cell ◽  
Ovariectomized Mice ◽  
Adipose Inflammation ◽  
Adipose Mass

scholarly journals Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

2002 ◽  
Vol 109 (12) ◽  
pp. 1551-1559 ◽  
Author(s):  
Rebecca S. Muraoka ◽  
Nancy Dumont ◽  
Christoph A. Ritter ◽  
Teresa C. Dugger ◽  
Dana M. Brantley ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Viability ◽  
Mammary Tumor ◽  
Mammary Tumor Cell

Isolation, Identification, and Assay of [3H]-Porfiromycin Adducts of EMT6 Mouse Mammary Tumor Cell DNA: Effects of Hypoxia and Dicumarol on Adduct Patterns

1991 ◽  
Vol 3 (7) ◽  
pp. 213-223 ◽  
Author(s):  
Maria Tomasz ◽  
Christine S. Hughes ◽  
Dondapati Chowdary ◽  
Susan Riley Keyes ◽  
Roselyn Lipman ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Mammary Tumor ◽  
Mammary Tumor Cell ◽  
Mouse Mammary Tumor ◽  
Mouse Mammary Tumor Cell

scholarly journals CXCR2: A Novel Mediator of Mammary Tumor Bone Metastasis

2019 ◽  
Vol 20 (5) ◽  
pp. 1237 ◽  
Author(s):  
Bhawna Sharma ◽  
Kalyan Nannuru ◽  
Sugandha Saxena ◽  
Michelle Varney ◽  
Rakesh Singh
Keyword(s):  
Breast Cancer ◽  
Bone Metastasis ◽  
Tumor Cell ◽  
Cancer Patients ◽  
Mammary Tumor ◽  
Critical Role ◽  
Breast Cancer Patients ◽  
Mammary Tumor Cell ◽  
Primary Tumors

Most breast cancer patients die due to bone metastasis. Although metastasis accounts for 5% of the breast cancer cases, it is responsible for most of the deaths. Sometimes even before the detection of a primary tumor, most of the patients have bone and lymph node metastasis. Moreover, at the time of death, breast cancer patients have the bulk of the tumor burden in their bones. Therapy options are available for the treatment of primary tumors, but there are minimal options for treating breast cancer patients who have bone metastasis. C-X-C motif chemokine receptor type 2 (CXCR2) receptor-mediated signaling has been shown to play a critical role during bone-related inflammations and its ligands C-X-C motif chemokine ligand 6 (CXCL6) and 8 (CXCL8) aid in the resorption of bone during bone metastasis. In this study, we tested the hypothesis that CXCR2 contributes to mammary tumor-induced osteolysis and bone metastasis. In the present study, we examined the role of both tumor cell-derived and host-derived CXCR2 in influencing mammary tumor cell bone metastasis. For understanding the role of tumor cell-derived CXCR2, we utilized Cl66 CXCR2 knockdown (Cl66-shCXCR2) and Cl66-Control cells (Cl66-Control) and observed a significant decrease in tumor growth and tumor-induced osteolysis in Cl66-shCXCR2 cells in comparison with the Cl66-Control cells. Next, for understanding the role of host-derived CXCR2, we utilized mice with genomic knockdown of CXCR2 (Cxcr2−/−) and injected Cl66-Luciferase (Cl66-Luc) or 4T1-Luciferase (4T1-Luc) cells. We observed decreased bone destruction and metastasis in the bone of Cxcr2−/− mice. Our data suggest the importance of both tumor cell- and host-derived CXCR2 signaling in the bone metastasis of breast cancer cells.

Abstract 4214: Stem cell antigen-1 (Sca1) modulates PI3K/PTEN signaling and mammary tumor cell survival

2010 ◽  
Author(s):  
Geeta Upadhyay ◽  
Claire Pollock ◽  
Yuzhi Yin ◽  
Hongyan Yuan ◽  
Levi Kopelovich ◽  
...  
Keyword(s):  
Stem Cell ◽  
Tumor Cell ◽  
Cell Survival ◽  
Mammary Tumor ◽  
Mammary Tumor Cell ◽  
Cell Antigen ◽  
Tumor Cell Survival

Establishment and characterization of a new murine mammary tumor cell line, balb/c-MC

1987 ◽  
Vol 23 (11) ◽  
pp. 755-758 ◽  
Author(s):  
Junji Morimoto ◽  
Shunsuke Imai ◽  
Yuzo Taniguchi ◽  
Yoshihiko Tsubura ◽  
Howard L. Hosick
Keyword(s):  
Tumor Cell ◽  
Cell Line ◽  
Mammary Tumor ◽  
Tumor Cell Line ◽  
Mammary Tumor Cell ◽  
Mammary Tumor Cell Line ◽  
Murine Mammary Tumor
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