d -Allulose supplementation normalized the body weight and fat-pad mass in diet-induced obese mice via the regulation of lipid metabolism under isocaloric fed condition

2016 ◽  
Vol 60 (7) ◽  
pp. 1695-1706 ◽  
Author(s):  
Youngji Han ◽  
Hye Jin Han ◽  
Ae-Hyang Kim ◽  
Ji-Young Choi ◽  
Su-Jung Cho ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Metabolism ◽  
The Body ◽  
Obese Mice ◽  
Fat Pad

Effects of Agave tequilana fructans with different degree of polymerization profiles on the body weight, blood lipids and count of fecal Lactobacilli/Bifidobacteria in obese mice

2013 ◽  
Vol 4 (8) ◽  
pp. 1237 ◽  
Author(s):  
Ana Laura Márquez-Aguirre ◽  
Rosa Maria Camacho-Ruiz ◽  
Myriam Arriaga-Alba ◽  
Eduardo Padilla-Camberos ◽  
Manuel Reinhart Kirchmayr ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Lipids ◽  
Degree Of Polymerization ◽  
The Body ◽  
Agave Tequilana ◽  
Obese Mice

Effect of Changes in Ambient Temperature on Spontaneous Activity, Food Intake and Body Weight of Goldthioglucose-Obese and Nonobese Mice

1957 ◽  
Vol 188 (3) ◽  
pp. 435-438 ◽  
Author(s):  
M. J. Fregly ◽  
N. B. Marshall ◽  
J. Mayer
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Ambient Temperature ◽  
The Body ◽  
Lower Body ◽  
Obese Mice ◽  
Ambient Temperatures ◽  
Exposure To Cold ◽  
Running Activity ◽  
Body Weights

Goldthioglucose-obese mice cannot adjust their food intake to meet the increased energy requirements due to cold. At all ambient temperatures above 15°C the spontaneous running activity of these animals is less than that observed for nonobese controls. Activity of obese mice is maximal at 19°C and minimal at 15°C or lower. Body weights decrease during exposure to cold. In contrast to that of obese mice, running activity of nonobese controls is maximal at an ambient temperature of 25°C but nearly ceases at 15°C or lower. The food intake of these animals increases in the cold and remains elevated even at temperatures at which activity decreases. The body weight of nonobese controls is either maintained constant or increases during exposure to cold air.

scholarly journals Anti-Obesity Effects of Collagen Peptide Derived from Skate (Raja kenojei) Skin Through Regulation of Lipid Metabolism

Marine Drugs ◽  
2018 ◽  
Vol 16 (9) ◽  
pp. 306 ◽  
Author(s):  
Minji Woo ◽  
Yeong Song ◽  
Keon-Hee Kang ◽  
Jeong Noh
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Lipid Metabolism ◽  
Protein Expression ◽  
The Body ◽  
Chow Diet ◽  
Dependent Manner ◽  
Hepatic Lipid ◽  
Collagen Peptide

This study investigated the anti-obesity effects of collagen peptide derived from skate skin on lipid metabolism in high-fat diet (HFD)-fed mice. All C57BL6/J male mice were fed a HFD with 60% kcal fat except for mice in the normal group which were fed a chow diet. The collagen-fed groups received collagen peptide (1050 Da) orally (100, 200, or 300 mg/kg body weight per day) by gavage, whereas the normal and control groups were given water (n = 9 per group). The body weight gain and visceral adipose tissue weight were lower in the collagen-fed groups than in the control group (p < 0.05). Plasma and hepatic lipid levels were significantly reduced by downregulating the hepatic protein expression levels for fatty acid synthesis (sterol regulatory element binding protein-1 (SREBP-1), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC)) and cholesterol synthesis (SREBP-2 and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)) and upregulating those for β-oxidation (peroxisome proliferator-activated receptor alpha (PPAR-α) and carnitine palmitoyltransferase 1 (CPT1)) and synthesis of bile acid (cytochrome P450 family 7 subfamily A member 1 (CYP7A1)) (p < 0.05). In the collagen-fed groups, the hepatic protein expression level of phosphorylated 5′ adenosine monophosphate-activated protein kinase (p-AMPK) and plasma adiponectin levels were higher, and the leptin level was lower (p < 0.05). Histological analysis revealed that collagen treatment suppressed hepatic lipid accumulation and reduced the lipid droplet size in the adipose tissue. These effects were increased in a dose-dependent manner. The findings indicated that skate collagen peptide has anti-obesity effects through suppression of fat accumulation and regulation of lipid metabolism.

scholarly journals Anti-obesity Effect of (8-E)-Nüzhenide, a Secoiridoid from Ligustrum lucidum, in High-fat Diet-induced Obese Mice

2014 ◽  
Vol 9 (10) ◽  
pp. 1934578X1400901 ◽  
Author(s):  
Qing Liu ◽  
Sang Hyun Kim ◽  
Seon Beom Kim ◽  
Yang Hee Jo ◽  
Eun Sil Kim ◽  
...  
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
Treated Group ◽  
The Body ◽  
Metabolic Parameters ◽  
Obese Mice ◽  
High Fat ◽  
Ligustrum Lucidum ◽  
Epididymal Fat

The effect of the extract of Ligustrum lucidum fruits (LFE) and its major secoiridoid (LFS), (8- E)-nüzhenide, on obesity was investigated using high fat-diet (HFD)-induced C58BL/6J obese mice. LFE and LFS were administered at the doses of 300 mg/kg and 30 mg/kg, respectively, for 6 weeks. The anti-obesity activity was evaluated by measuring body weight, epididymal fat and metabolic plasma parameters. On Day 42, the body weight of the LFS-treated group was significantly lower compared with the HFD-treated group. Body weight gain was also reduced by 23.2% and 32.0% in the LFE- and LFS-treated groups, respectively, compared with the HFD group. In addition, the weight of the epididymal fat in the mice was significantly decreased in the HFD+LFS group. The food efficiency ratios (FERs) of the HFD+LFE and HFD+LFS groups were also lower compared with the HFD group with the same food intake. Metabolic parameters that had increased in the HFD group were decreased in the HFD+LFE and HFD+LFS groups. In particular, the increased triglyceride values were significantly reduced in the HFD+LFS group. These results show that treatment with LFE and LFS decreased HFD-induced obesity, mainly by improving metabolic parameters, such as fats and triglycerides. Therefore, LFE and LFS have potential benefits in regulation of obesity.

scholarly journals Effect of the Bacillus subtilis-based drug on the morphobiochemical and productive parameters of calves

2021 ◽  
Vol 273 ◽  
pp. 02011
Author(s):  
Galina Molyanova ◽  
Maxim Nogotkov ◽  
Nelly Chigina
Keyword(s):  
Body Weight ◽  
Bacillus Subtilis ◽  
Lipid Metabolism ◽  
Average Daily Gain ◽  
Dairy Farm ◽  
The Body ◽  
Control Group ◽  
Production Experiment ◽  
Daily Gain ◽  
Experimental Group

The effect of Bisolbi drug based on Bacillus subtilis on the physiological, biochemical and productive parameters of calves was studied. The research and production experiment was carried out in a dairy farm “Kupinskoe” of Samara Region on 30 calves of the Holstein-Frisian breed. The drug increases the intensity of the anabolic processes in animals: the amount of total protein in blood serum of calves of the experimental group at 120 days of age was higher by 8.9% (p≤0.05), albumin 9.2% (p≤0.01), compared with control animals. The purpose of Bisolbi contributed to the increase in the intensity of carbohydrate-lipid metabolism: cholesterol was higher by 23% (p≤0.01), glucose 0.4 mmol/l (p≤0.05) in blood 120-day calves of the experimental group, relative to the data of the control group. It was found that the body weight of calves in the control group at 100 days of age was 105.23±2.11 kg, in the experimental group -108.6±2.19 kg. The average daily gain in the experimental group was significantly higher by 0.075 kg (p≤0.01). At 120 days of age, the body weight of the experimental calves was higher by 4.19 kg (p≤0.05), the average daily increase by 0.080 kg (p≤0.05), relative to the control animals.

scholarly journals Evaluation of Polyherbal Formulation (Kemite) on Cafeteria Diet-induced Obesity in Wistar Rats

2021 ◽  
Vol 70 (1) ◽  
Author(s):  
GNANGORAN Boua Narcisse ◽  
Traoré Moussa ◽  
YAPO Angoué Paul
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Risk Index ◽  
The Body ◽  
Cafeteria Diet ◽  
Atherogenic Index ◽  
Coronary Risk ◽  
Fat Pad

Obesity is a chronic disorder of global prevalence and associated with morbidity and mortality. This pathology is a real public health problem. The work was undertaken to evaluate the antiobesity efficacy of aqueous extract of Kemite in cafeteria diet induced obese Wistar rats for a period of 28 days. Aqueous extract of Kemite (AEK) was prepared by hot extraction method. Female Wistar rats weighing 124-170 g were divided into different groups i.e. Normal control, cafeteria control and aqueous extract of Kemite at dose of 200 mg/kg bw. The antiobesity activity is estimated in terms of body weight gain, food intake, serum triglycerides (TG), Total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), VLDL cholesterol (VLDL-C), blood glucose (BG), ASAT and ALAT activities, atherogenic index, coronary risk index and liver and fat pad weights. Results showed Cafeteria diet fed rats for 28 successive days significantly increased the body weight, food intake, ASAT and ALAT activities, liver and fat pad weights, atherogenic index, coronary risk index TG, TC, LDL, VLDL, BG and not influenced HDL levels. Rats treated with extract for 28 successive days along with cafeteria diet reversed the effects induced by cafeteria diet. In conclusion, this study revealed that AEK may be a natural and safe remedy for the prevention and control of obesity.

Mifepristone (RU 486), a blocker of type II glucocorticoid and progestin receptors, reverses a dietary form of obesity

1992 ◽  
Vol 262 (6) ◽  
pp. R1106-R1110 ◽  
Author(s):  
S. Okada ◽  
D. A. York ◽  
G. A. Bray
Keyword(s):  
Body Weight ◽  
Glucocorticoid Receptors ◽  
Body Weight Gain ◽  
The Body ◽  
Receptor Activity ◽  
Minor Role ◽  
Type Ii ◽  
Fat Pad ◽  
Ru 486 ◽  
A Minor

The effect of mifepristone (RU 486), a blocker of type II glucocorticoid receptors on the development of obesity that follows the feeding of a high-fat (HF) diet to Osborne-Mendel (OM) rats, has been investigated. OM rats fed a HF diet gained more weight and had larger retroperitoneal and parametrial fat pads than OM rats fed a high-carbohydrate low-fat (LF) diet. RU 486 (30 mg.kg-1.day-1) for 14 days completely reversed the body weight gain and the increase in fat pad size of OM rats fed a HF diet. RU 486 had no effect on body weight of OM rats fed a LF diet, but did reduce fat pad weights. The data suggest that type II glucocorticoid receptor activity modulates body fat deposition and is essential for the development of obesity, although a minor role for progestin receptor activity cannot be ruled out.

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