scholarly journals Daidzein and genistein fail to improve glycemic control and insulin sensitivity in Chinese women with impaired glucose regulation: A double‐blind, randomized, placebo‐controlled trial

2014 ◽  
Vol 59 (2) ◽  
pp. 240-249 ◽  
Author(s):  
Yan‐Bin Ye ◽  
Ai‐Ling Chen ◽  
Wei Lu ◽  
Shu‐Yu Zhuo ◽  
Juan Liu ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Glycemic Control ◽  
Chinese Women ◽  
Controlled Trial ◽  
Glucose Regulation ◽  
Impaired Glucose Regulation ◽  
Double Blind

Effects of daidzein and genistein on markers of cardiovascular disease risk among women with impaired glucose regulation: A double-blind, randomized, placebo-controlled trial

2021 ◽  
Author(s):  
Yanbin Ye ◽  
Kai-yin He ◽  
Wan-lin Li ◽  
Shu-yu Zhuo ◽  
Yu M. Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Soy Protein ◽  
Disease Risk ◽  
Controlled Trial ◽  
Cardiovascular Disease Risk ◽  
Soy Isoflavones ◽  
Glucose Regulation ◽  
Impaired Glucose Regulation ◽  
Double Blind

Background and objective: Soy protein and soy isoflavones have been suggested to be associated with improved cardiovascular risk factors (e.g., lipid profiles and uric acid (UA)), but few studies have...

scholarly journals Lactobacillus plantarum HAC01 Supplementation Improves Glycemic Control in Prediabetic Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2337
Author(s):  
Mi-Ra Oh ◽  
Hui-Yeon Jang ◽  
Si-Yeon Lee ◽  
Su-Jin Jung ◽  
Soo-Wan Chae ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Lactobacillus Plantarum ◽  
Human Subjects ◽  
Controlled Trial ◽  
Short Chain Fatty Acids ◽  
Postprandial Glucose ◽  
Microbiota Composition ◽  
Double Blind ◽  
Single Strain ◽  
Hba1c Levels

A recent animal study demonstrated that administration of Lactobacillus plantarum HAC01 isolated from Korean kimchi improved glycemic control in type 2 diabetic mice. In the present study, we evaluated Lactobacillus plantarum HAC01’s effects on metabolic parameters of prediabetic human subjects. Forty subjects with isolated impaired glucose tolerance were randomly assigned to receive a daily placebo (n = 20) or a dose of Lactobacillus plantarum HAC01 (n = 20) over eight weeks. The primary endpoint was a change in 2 h postprandial glucose (2h-PPG) levels and the secondary endpoints were assessment of other glucose metabolism parameters, including HbA1c, gut microbiota composition, and fecal short-chain fatty acids (SCFAs). The group with a diet supplemented with Lactobacillus plantarum HAC01 saw a significant reduction in 2h-PPG and HbA1c levels compared to the placebo group. Fasting plasma glucose, insulin, HOMA-IR, QUICKI, microbiota composition, and fecal SCFAs, however, were not significantly altered. No serious adverse effects were reported. This is the first clinical trial to show a beneficial effect of single-strain probiotic supplementation administered over eight weeks on HbA1c levels in prediabetic subjects.

scholarly journals GH effect on enzyme activity of 11βHSD in abdominal obesity is dependent on treatment duration

2006 ◽  
Vol 154 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Helga Á Sigurjónsdóttir ◽  
Josef Koranyi ◽  
Magnus Axelson ◽  
Bengt-Åke Bengtsson ◽  
Gudmundur Johannsson
Keyword(s):  
Insulin Sensitivity ◽  
Abdominal Obesity ◽  
Fat Mass ◽  
Visceral Fat ◽  
Controlled Trial ◽  
Metabolic Effects ◽  
Glucose Disposal ◽  
Gh Treatment ◽  
Double Blind

Objective: In the past years the interaction of GH and 11βhydroxysteroid dehydrogenase (11βHSD) in the pathogenesis of central obesity has been suggested. Design: We studied the effects of 9 months of GH treatment on 11βHSD activity and its relationship with body composition and insulin sensitivity in 30 men with abdominal obesity, aged 48–66 years, in a randomised, double-blind, placebo-controlled trial. Methods: Urinary steroid profile was used to estimate 11βHSD type 1 and 2 (11βHSD1 and 11βHSD2) activities. Abdominal s.c. and visceral adipose tissues were measured using computed tomography. Glucose disposal rate (GDR) obtained during a euglycaemic–hyperinsulinaemic glucose clamp was used to assess insulin sensitivity. Results: In the GH-treated group the 11βHSD1 activity decreased transiently after 6 weeks (P < 0.01) whereas 11βHSD2 increased after 9 months of treatment (P < 0.05). Between 6 weeks and 9 months, GDR increased and visceral fat mass decreased. Changes in 11βHSD1 correlated with changes in visceral fat mass between baseline and 6 weeks. There were no significant correlations between 11βHSD1 and 11βHSD 2 and changes in GDR. Discussion: The study demonstrates that short- and long-term GH treatment has different effects on 11βHSD1 and 11βHSD2 activity. Moreover, the data do not support that long-term metabolic effects of GH are mediated through its action on 11βHSD.

Effects of low doses of fish and milk proteins on glucose regulation and markers of insulin sensitivity in overweight adults: a randomised, double blind study

2019 ◽  
Vol 59 (3) ◽  
pp. 1013-1029 ◽  
Author(s):  
Ida Heir Hovland ◽  
Ingrid Sande Leikanger ◽  
Oddbjørg Stokkeland ◽  
Kaia Hevrøy Waage ◽  
Svein A. Mjøs ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Milk Proteins ◽  
Blind Study ◽  
Glucose Regulation ◽  
Double Blind Study ◽  
Low Doses ◽  
Double Blind ◽  
Overweight Adults
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