Phenylpropenoic acid glucoside augments pancreatic beta cell mass in high-fat diet-fed mice and protects beta cells from ER stress-induced apoptosis

2014 ◽  
Vol 58 (10) ◽  
pp. 1980-1990 ◽  
Author(s):  
Iris Mathijs ◽  
Daniel A. Da Cunha ◽  
Eddy Himpe ◽  
Laurence Ladriere ◽  
Nireshni Chellan ◽  
...  
Keyword(s):  
Beta Cell ◽  
Er Stress ◽  
Beta Cells ◽  
High Fat Diet ◽  
Pancreatic Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
High Fat ◽  
Induced Apoptosis ◽  
Pancreatic Beta Cell Mass

scholarly journals p8 deficiency leads to elevated pancreatic beta cell mass but does not contribute to insulin resistance in mice fed with high-fat diet

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0201159
Author(s):  
Marcus Hollenbach ◽  
Nora Klöting ◽  
Ines Sommerer ◽  
Jana Lorenz ◽  
Mario Heindl ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Beta Cell ◽  
High Fat Diet ◽  
Pancreatic Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
High Fat ◽  
Pancreatic Beta Cell Mass

scholarly journals MicroRNA-24 promotes pancreatic beta cells toward dedifferentiation to avoid endoplasmic reticulum stress-induced apoptosis

2019 ◽  
Vol 11 (9) ◽  
pp. 747-760 ◽  
Author(s):  
Yunxia Zhu ◽  
Yi Sun ◽  
Yuncai Zhou ◽  
Yan Zhang ◽  
Tao Zhang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Beta Cell ◽  
Er Stress ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Stress Conditions ◽  
Beta Cell Apoptosis ◽  
Induced Apoptosis

AbstractCurrent research indicates that beta cell loss in type 2 diabetes may be attributed to beta cell dedifferentiation rather than apoptosis; however, the mechanisms by which this occurs remain poorly understood. Our previous study demonstrated that elevation of microRNA-24 (miR-24) in a diabetic setting caused beta cell dysfunction and replicative deficiency. In this study, we focused on the role of miR-24 in beta cell apoptosis and dedifferentiation under endoplasmic reticulum (ER) stress conditions. We found that miR-24 overabundance protected beta cells from thapsigargin-induced apoptosis at the cost of accelerating the impairment of glucose-stimulated insulin secretion (GSIS) and enhancing the presence of dedifferentiation markers. Ingenuity® Pathway Analysis (IPA) revealed that elevation of miR-24 had an inhibitory effect on XBP1 and ATF4, which are downstream effectors of two key branches of ER stress, by inhibiting its direct target, Ire1α. Notably, elevated miR-24 initiated another pathway that targeted Mafa and decreased GSIS function in surviving beta cells, thus guiding their dedifferentiation under ER stress conditions. Our results demonstrated that the elevated miR-24, to the utmost extent, preserves beta cell mass by inhibiting apoptosis and inducing dedifferentiation. This study not only provides a novel mechanism by which miR-24 dominates beta cell turnover under persistent metabolic stress but also offers a therapeutic consideration for treating diabetes by inducing dedifferentiated beta cells to re-differentiation.

scholarly journals The Class I Histone Deacetylase Inhibitor MS-275 Prevents Pancreatic Beta Cell Death Induced by Palmitate

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Valérie Plaisance ◽  
Laure Rolland ◽  
Valéry Gmyr ◽  
Jean-Sébastien Annicotte ◽  
Julie Kerr-Conte ◽  
...  
Keyword(s):  
Cell Death ◽  
Beta Cell ◽  
Er Stress ◽  
Beta Cells ◽  
Pancreatic Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Activating Transcription Factor 3 ◽  
Beta Cell Death ◽  
Stress Markers

Elevation of the dietary saturated fatty acid palmitate contributes to the reduction of functional beta cell mass in the pathogenesis of type 2 diabetes. The diabetogenic effect of palmitate is achieved by increasing beta cell death through induction of the endoplasmic reticulum (ER) stress markers including activating transcription factor 3 (Atf3) and CAAT/enhancer-binding protein homologous protein-10 (Chop). In this study, we investigated whether treatment of beta cells with the MS-275, a HDAC1 and HDAC3 activity inhibitor which prevents beta cell death elicited by cytokines, is beneficial for combating beta cell dysfunction caused by palmitate. We show that culture of isolated human islets and MIN6 cells with MS-275 reduced apoptosis evoked by palmitate. The protective effect of MS-275 was associated with the attenuation of the expression of Atf3 and Chop. Silencing of HDAC3, but not of HDAC1, mimicked the effects of MS-275 on the expression of the two ER stress markers and apoptosis. These data point to HDAC3 as a potential drug target for preserving beta cells against lipotoxicity in diabetes.

scholarly journals Autophagy protects pancreatic beta cell mass and function in the setting of a high-fat and high-glucose diet

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Qingfeng Sheng ◽  
Xiangwei Xiao ◽  
Krishna Prasadan ◽  
Congde Chen ◽  
Yungching Ming ◽  
...  
Keyword(s):  
Beta Cell ◽  
High Glucose ◽  
Pancreatic Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
High Fat ◽  
And Function ◽  
Pancreatic Beta Cell Mass

Investigation on the Protective Effect of Canagliflozin on Pancreatic Beta-Cell Mass Using SPECT/CT Imaging with 111In-Labeled Exendin-4

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2124-P
Author(s):  
KEITA HAMAMATSU ◽  
HIROYUKI FUJIMOTO ◽  
NAOTAKA FUJITA ◽  
TAKAAKI MURAKAMI ◽  
MASAHARU SHIOTANI ◽  
...  
Keyword(s):  
Beta Cell ◽  
Protective Effect ◽  
Pancreatic Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Ct Imaging ◽  
Pancreatic Beta Cell Mass

Novel Use of Agent11C-PHNO for Pet CT Imaging of Pancreatic Beta-Cell Mass

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2145-P
Author(s):  
ELIZABETH SANCHEZ RANGEL ◽  
JASON BINI ◽  
NABEEL B. NABULSI ◽  
YIYUN HUANG ◽  
KEVAN C. HEROLD ◽  
...  
Keyword(s):  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Ct Imaging ◽  
Pet Ct ◽  
Pancreatic Beta Cell Mass
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