β-Sitosterol attenuates high-fat diet-induced intestinal inflammation in mice by inhibiting the binding of lipopolysaccharide to toll-like receptor 4 in the NF-κB pathway

2014 ◽  
Vol 58 (5) ◽  
pp. 963-972 ◽  
Author(s):  
Kyung-Ah Kim ◽  
In-Ah Lee ◽  
Wan Gu ◽  
Supriya R. Hyam ◽  
Dong-Hyun Kim
Keyword(s):  
High Fat Diet ◽  
Intestinal Inflammation ◽  
Toll Like Receptor ◽  
High Fat ◽  
Toll Like Receptor 4

scholarly journals Apolipoprotein E deficiency and high-fat diet cooperate to trigger lipidosis and inflammation in the lung via the toll-like receptor 4 pathway

2015 ◽  
Vol 12 (2) ◽  
pp. 2589-2597 ◽  
Author(s):  
QIUFANG OUYANG ◽  
ZIYANG HUANG ◽  
HUILI LIN ◽  
JINGQIN NI ◽  
HUIXIA LU ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
High Fat Diet ◽  
Toll Like Receptor ◽  
High Fat ◽  
Toll Like Receptor 4

scholarly journals Selective overexpression of Toll-like receptor-4 in skeletal muscle impairs metabolic adaptation to high-fat feeding

2015 ◽  
Vol 309 (3) ◽  
pp. R304-R313 ◽  
Author(s):  
Ryan P. McMillan ◽  
Yaru Wu ◽  
Kevin Voelker ◽  
Gabrielle Fundaro ◽  
John Kavanaugh ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
High Fat Diet ◽  
Whole Body ◽  
Metabolic Adaptation ◽  
Acid Oxidation ◽  
Chow Diet ◽  
Toll Like Receptor ◽  
High Fat ◽  
Toll Like Receptor 4 ◽  
Fat Feeding

Toll-like receptor-4 (TLR-4) is elevated in skeletal muscle of obese humans, and data from our laboratory have shown that activation of TLR-4 in skeletal muscle via LPS results in decreased fatty acid oxidation (FAO). The purpose of this study was to determine whether overexpression of TLR-4 in skeletal muscle alters mitochondrial function and whole body metabolism in the context of a chow and high-fat diet. C57BL/6J mice (males, 6–8 mo of age) with skeletal muscle-specific overexpression of the TLR-4 (mTLR-4) gene were created and used for this study. Isolated mitochondria and whole muscle homogenates from rodent skeletal muscle (gastrocnemius and quadriceps) were investigated. TLR-4 overexpression resulted in a significant reduction in FAO in muscle homogenates; however, mitochondrial respiration and reactive oxygen species (ROS) production did not appear to be affected on a standard chow diet. To determine the role of TLR-4 overexpression in skeletal muscle in response to high-fat feeding, mTLR-4 mice and WT control mice were fed low- and high-fat diets for 16 wk. The high-fat diet significantly decreased FAO in mTLR-4 mice, which was observed in concert with elevated body weight and fat, greater glucose intolerance, and increase in production of ROS and cellular oxidative damage compared with WT littermates. These findings suggest that TLR-4 plays an important role in the metabolic response in skeletal muscle to high-fat feeding.

scholarly journals Obesity Takes Its Toll on Visceral Pain: High-Fat Diet Induces Toll-Like Receptor 4-Dependent Visceral Hypersensitivity

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0155367 ◽  
Author(s):  
Mónica Tramullas ◽  
Beate C. Finger ◽  
Timothy G. Dinan ◽  
John F. Cryan
Keyword(s):  
High Fat Diet ◽  
Visceral Pain ◽  
Visceral Hypersensitivity ◽  
Toll Like Receptor ◽  
High Fat ◽  
Toll Like Receptor 4

scholarly journals Loss of Toll-Like Receptor 4 Function Partially Protects against Peripheral and Cardiac Glucose Metabolic Derangements During a Long-Term High-Fat Diet

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142077 ◽  
Author(s):  
Ellen E. Jackson ◽  
Elisabeth Rendina-Ruedy ◽  
Brenda J. Smith ◽  
Veronique A. Lacombe
Keyword(s):  
High Fat Diet ◽  
Toll Like Receptor ◽  
High Fat ◽  
Toll Like Receptor 4
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