scholarly journals 5-Demethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G2/M cell cycle arrest and apoptosis

2013 ◽  
Vol 57 (12) ◽  
pp. 2103-2111 ◽  
Author(s):  
Noppawat Charoensinphon ◽  
Peiju Qiu ◽  
Ping Dong ◽  
Jinkai Zheng ◽  
Pearline Ngauv ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Nonsmall Cell Lung Cancer ◽  
Lung Cancer Cell ◽  
M Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest

Ganoderma tsugae extracts inhibit colorectal cancer cell growth via G2/M cell cycle arrest

2008 ◽  
Vol 120 (3) ◽  
pp. 394-401 ◽  
Author(s):  
Shih-Chung Hsu ◽  
Chien-Chih Ou ◽  
Jhy-Wei Li ◽  
Tzu-Chao Chuang ◽  
Han-Pon Kuo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
M Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest

scholarly journals Effects of Dihydroartemisinin, a Metabolite of Artemisinin, on Colon Cancer Chemoprevention and Adaptive Immune Regulation

2021 ◽  
Author(s):  
Chong-Zhi Wang ◽  
Chunping Wan ◽  
Yun Luo ◽  
Chun-Feng Zhang ◽  
Qi-Hui Zhang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Immune Regulation ◽  
M Cell ◽  
Cancer Cell Growth ◽  
Adaptive Immune ◽  
Cycle Arrest ◽  
Anti Inflammation

Abstract Artemisinin (ART) is an anti-malaria natural compound with a moderate anticancer action. As a metabolite of ART, dihydroartemisinin (DHA) may have stronger anti-colorectal cancer (CRC) bioactivities. However, the effects of DHA and ART on CRC chemoprevention have not been systematically evaluated and compared, including on adaptive immune regulation. Coupled with a newly-established HPLC analytical method, enteric microbiome biotransformation was conducted to identify if the DHA is a gut microbial metabolite of ART. The anti-CRC potential of these compounds was compared using two different human CRC cell lines for cell cycle arrest, apoptotic induction, and anti-inflammation activities. Naive CD4+ T cells were also obtained for testing the compounds on the differentiation of Treg, Th1 and Th17. Using compound extraction and analytical methods, we observed for the first time that ART completely converted into its metabolites within 24 h, but no DHA was detected. Although ART did not obviously influence cancer cell growth in the concentration tested, DHA very significantly inhibited the cancer cell growth at relatively low concentrations. DHA included G2/M cell cycle arrest via upregulation of cyclin A and apoptosis. Both ART and DHA downregulated the pro-inflammatory cytokine expression. The DHA significantly promoted Treg cell proliferation, while both ART and DHA inhibited Th1 and Th17 cell differentiation. As a metabolite of ART, DHA possessed stronger anti-CRC activities. The DHA significantly inhibited cell growth via cell cycle arrest, apoptosis induction and anti-inflammation actions. The adaptive immune regulation is a related mechanism of actions for the observed effects.

scholarly journals ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis

2016 ◽  
Vol 7 (1) ◽  
pp. 60-68 ◽  
Author(s):  
Xingjie Ma ◽  
Minlu Huang ◽  
Zhenqiang Wang ◽  
Bingya Liu ◽  
Zhenggang Zhu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest

A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest

2006 ◽  
Vol 340 (4) ◽  
pp. 1224-1228 ◽  
Author(s):  
Michael B. Ujiki ◽  
Ben Milam ◽  
Xian-Zhong Ding ◽  
Alexandra B. Roginsky ◽  
M. Reza Salabat ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest

scholarly journals ICT1 knockdown inhibits breast cancer cell growth via induction of cell cycle arrest and apoptosis

2017 ◽  
Vol 39 (4) ◽  
pp. 1037-1045 ◽  
Author(s):  
Chen Wang ◽  
Chenlu Liang ◽  
Weiliang Feng ◽  
Xianghou Xia ◽  
Feng Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Cycle Arrest

Molecular imaging of p53 signal pathway in lung cancer cell cycle arrest induced by cisplatin

2012 ◽  
Vol 52 (11) ◽  
pp. 900-907 ◽  
Author(s):  
Shenxu Wang ◽  
Weijie Li ◽  
Zengfu Xue ◽  
Yuanyuan Lu ◽  
Kazim Narsinh ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Molecular Imaging ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Signal Pathway ◽  
Lung Cancer Cell ◽  
Cycle Arrest

scholarly journals Cidan inhibits liver cancer cell growth by reducing COX-2 and VEGF expression and cell cycle arrest

2015 ◽  
Vol 9 (5) ◽  
pp. 1709-1718 ◽  
Author(s):  
NAN LI ◽  
DONGHAI ZHENG ◽  
JIE XUE ◽  
WEIXING GUO ◽  
JIE SHI ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Liver Cancer ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Liver Cancer Cell ◽  
Vegf Expression ◽  
Cancer Cell Growth ◽  
Cycle Arrest ◽  
Cox 2
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