Resveratrol 3-O -d -glucuronide and resveratrol 4′-O -d -glucuronide inhibit colon cancer cell growth: Evidence for a role of A3 adenosine receptors, cyclin D1 depletion, and G1 cell cycle arrest

2013 ◽  
Vol 57 (10) ◽  
pp. 1708-1717 ◽  
Author(s):  
Elena Polycarpou ◽  
Lisiane B. Meira ◽  
Simon Carrington ◽  
Elizabeth Tyrrell ◽  
Helmout Modjtahedi ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Adenosine Receptors ◽  
Colon Cancer Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest

A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest

2006 ◽  
Vol 340 (4) ◽  
pp. 1224-1228 ◽  
Author(s):  
Michael B. Ujiki ◽  
Ben Milam ◽  
Xian-Zhong Ding ◽  
Alexandra B. Roginsky ◽  
M. Reza Salabat ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest

scholarly journals ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis

2016 ◽  
Vol 7 (1) ◽  
pp. 60-68 ◽  
Author(s):  
Xingjie Ma ◽  
Minlu Huang ◽  
Zhenqiang Wang ◽  
Bingya Liu ◽  
Zhenggang Zhu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest

G1 Cell-Cycle Arrest and Apoptosis by Histone Deacetylase Inhibition in MLL-AF9 Acute Myeloid Leukemia Cells Is MLL-AF9 Independent.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 4410-4410
Author(s):  
Roberto Tonelli ◽  
Roberta Sartini ◽  
Raffaele Fronza ◽  
Francesca Freccero ◽  
Monica Franzoni ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Myeloid Leukemia ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Myeloid Leukemia ◽  
Combined Treatment ◽  
Histone Deacetylase Inhibition ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest ◽  
Acute Myeloid

Abstract Acute myeloid leukemia (AML) with MLL rearrangements (MLLmut), found mainly in M5 or M4 FAB subtypes, is frequent in infants and secondary leukemias. The most common MLL translocation gives rise to MLL-AF9. MLL protein interacts with histone deacetylases (HDACs) -1 and -2 through the MLL repression domain. We report the effects of HDAC inhibition by valproic acid (VPA) in MLL-AF9 AML-M5 cells (THP-1, MM6 and MOLM-13) and MLLmut AML-M5 blasts. VPA led to histone hyper-acetylation, strong cell-growth inhibition, G1 cell-cycle arrest and apoptosis. Combined treatment with all-trans-retinoic-acid (ATRA) did not substantially improve these effects. VPA increased MLL-AF9 transcription, indicating that VPA overcomes the cell-growth promoting activity and resistance to apoptosis conferred by MLL-AF9 in AML-M5 cells, even with increased MLL-AF9. A small number of genes were significantly affected by VPA in p53-absent THP-1 cells (GeneChip analysis), and the majority of these were up-regulated. VPA potently induced p21 and cyclin G2 (CG2) expression. p21 and CG2 targeted inhibition demonstrated that p21 acts as a key regulator in the VPA-inducted G1 cell-cycle arrest, while induction of CG2 has no effect. These data suggest that these poor prognosis patients may benefit from HDAC inhibitor therapy.

Ganoderma tsugae extracts inhibit colorectal cancer cell growth via G2/M cell cycle arrest

2008 ◽  
Vol 120 (3) ◽  
pp. 394-401 ◽  
Author(s):  
Shih-Chung Hsu ◽  
Chien-Chih Ou ◽  
Jhy-Wei Li ◽  
Tzu-Chao Chuang ◽  
Han-Pon Kuo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
M Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest
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