Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells

2011 ◽  
Vol 55 (11) ◽  
pp. 1646-1654 ◽  
Author(s):  
Jia-Ching Wu ◽  
Ching-Shu Lai ◽  
Vladimir Badmaev ◽  
Kalyanam Nagabhushanam ◽  
Chi-Tang Ho ◽  
...  
Keyword(s):  
Cell Death ◽  
Signaling Pathways ◽  
Mapk Signaling ◽  
Major Metabolite ◽  
Autophagic Cell Death ◽  
Human Leukemia ◽  
Mapk Signaling Pathways

scholarly journals C11 cyclopentenone from the ascidian Diplosoma sp. prevents epidermal growth factor-induced transformation of JB6 cells

2012 ◽  
Vol 2 (1) ◽  
pp. 4 ◽  
Author(s):  
Sergey N. Fedorov ◽  
Sergey A. Dyshlovoy ◽  
Larisa K. Shubina ◽  
Alla Guzii ◽  
Alexandra S. Kuzmich ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Signaling Pathways ◽  
Cellular Response ◽  
Cell Transformation ◽  
Soft Agar ◽  
Mapk Signaling ◽  
Human Leukemia ◽  
Epidermal Growth ◽  
Mapk Signaling Pathways

C<sub>11</sub> cyclopentenone, 5-hydroxy-7-prop-2-en- (E)-ylidene-7,7a-dihydro-2H-cyclopenta[b] pyran-6-one, isolated earlier from the sponges and ascidians, is known as a natural product possessing antimicrobial and cytotoxic properties. However, its cancer preventive activity has not been studied. Cancer preventive and proapoptotic properties of the compound as well as its effect on the main Mitogen- Activated Protein-Kinase (MAPK) signaling pathways were examined by the methods of epidermal growth factor- induced (EGFinduced) JB6 Cl41 P+ cell transformation in soft agar, flow cytometry, and MTS test of cell viability. Results: the compound inhibits EGFinduced neoplastic JB6 Cl41 P+ cell transformation in soft agar and induces apoptosis of HL-60 and THP-1 human leukemia cells. Jun N-terminal Kinase and p38 MAPK signaling pathways are involved in the cellular response to the treatment by the compound. Conclusions: 5-hydroxy-7-prop-2-en-(E)-ylidene- 7,7a-dihydro-2H-cyclopenta[b]pyran-6- one and other related marine C11 cyclopentenones have potential for development of a new antitumor agent in cancer prophylactics and should be further investigated.

Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism

APOPTOSIS ◽  
2010 ◽  
Vol 16 (2) ◽  
pp. 145-161 ◽  
Author(s):  
Jayaraj Ravindran ◽  
Nimesh Gupta ◽  
Mona Agrawal ◽  
A. S. Bala Bhaskar ◽  
P. V. Lakshmana Rao
Keyword(s):  
Cell Death ◽  
Signaling Pathways ◽  
Okadaic Acid ◽  
Mapk Signaling ◽  
Mapk Signaling Pathways ◽  
Dependent Mechanism
Sign in / Sign up

Export Citation Format

Share Document