GABA (γ-aminobutyric acid), a non-protein amino acid counters the β-adrenergic cascade-activated oncogenic signaling in pancreatic cancer: A review of experimental evidence

2011 ◽  
Vol 55 (12) ◽  
pp. 1745-1758 ◽  
Author(s):  
Hussein A. N. Al-Wadei ◽  
Mohammad F. Ullah ◽  
Mohammed Al-Wadei
Keyword(s):  
Pancreatic Cancer ◽  
Amino Acid ◽  
Experimental Evidence ◽  
Aminobutyric Acid ◽  
Oncogenic Signaling ◽  
Protein Amino Acid

scholarly journals In SilicoPrediction of Gamma-Aminobutyric Acid Type-A Receptors Using Novel Machine-Learning-Based SVM and GBDT Approaches

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Zhijun Liao ◽  
Yong Huang ◽  
Xiaodong Yue ◽  
Huijuan Lu ◽  
Ping Xuan ◽  
...  
Keyword(s):  
Amino Acid ◽  
Type A ◽  
Aminobutyric Acid ◽  
Gradient Boosting ◽  
Support Vector ◽  
Sequence Information ◽  
Gamma Aminobutyric Acid ◽  
K Nearest Neighbor ◽  
Protein Amino Acid ◽  
Acid Type

Gamma-aminobutyric acid type-A receptors (GABAARs) belong to multisubunit membrane spanning ligand-gated ion channels (LGICs) which act as the principal mediators of rapid inhibitory synaptic transmission in the human brain. Therefore, the category prediction ofGABAARs just from the protein amino acid sequence would be very helpful for the recognition and research of novel receptors. Based on the proteins’ physicochemical properties, amino acids composition and position, aGABAARclassifier was first constructed using a 188-dimensional (188D) algorithm at 90% cd-hit identity and compared with pseudo-amino acid composition (PseAAC) and ProtrWeb web-based algorithms for humanGABAARproteins. Then, four classifiers including gradient boosting decision tree (GBDT), random forest (RF), a library for support vector machine (libSVM), and k-nearest neighbor (k-NN) were compared on the dataset at cd-hit 40% low identity. This work obtained the highest correctly classified rate at 96.8% and the highest specificity at 99.29%. But the values of sensitivity, accuracy, and Matthew’s correlation coefficient were a little lower than those of PseAAC and ProtrWeb; GBDT and libSVM can make a little better performance than RF andk-NN at the second dataset. In conclusion, aGABAARclassifier was successfully constructed using only the protein sequence information.

scholarly journals Systemic induced resistance

2002 ◽  
Vol 38 (SI 1 - 6th Conf EFPP 2002) ◽  
pp. S122-S125
Author(s):  
Y. Cohen
Keyword(s):  
Amino Acid ◽  
Penicillium Chrysogenum ◽  
Plant Disease ◽  
Control Plant ◽  
Aminobutyric Acid ◽  
Systemic Resistance ◽  
Local Resistance ◽  
Protein Amino Acid ◽  
Soil Borne Pathogens ◽  
Induce Resistance

Biotic and abiotic agents may induce resistance in plants against pathogens. Abiotic agents may be synthetic or natural. The natural, non-protein amino acid BABA (DL-β-aminobutyric acid) induces systemic resistance in crop plants against pathogens. Dry, killed mycelia of Penicillium chrysogenum (DM) induces local resistance in plants against soil-borne pathogens. The activity of BABA and DM are described here in detail. Both products were shown to effectively control plant disease in nature.

Purification of Antihemophilic Factor (Factor VIII) by Amino Acid Precipitation*

1964 ◽  
Vol 11 (01) ◽  
pp. 064-074 ◽  
Author(s):  
Robert H Wagner ◽  
William D McLester ◽  
Marion Smith ◽  
K. M Brinkhous
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Factor Viii ◽  
Plasma Protein ◽  
Acid Precipitation ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Specific Procedure ◽  
Beta Alanine ◽  
Antihemophilic Factor

Summary1. The use of several amino acids, glycine, alpha-aminobutyric acid, alanine, beta-alanine, and gamma-aminobutyric acid, as plasma protein precipitants is described.2. A specific procedure is detailed for the preparation of canine antihemophilic factor (AHF, Factor VIII) in which glycine, beta-alanine, and gammaaminobutyric acid serve as the protein precipitants.3. Preliminary results are reported for the precipitation of bovine and human AHF with amino acids.

Isolation from atelia herbert-smithii pittier (sophoreae, leguminosae) and x-ray structure of cis-1-amino-3-hydroxymethyl-cyclobutane-1-carboxylic acid, an achiral non-protein amino acid

Tetrahedron ◽  
1987 ◽  
Vol 43 (8) ◽  
pp. 1857-1861 ◽  
Author(s):  
Geoffrey N. Austin ◽  
Peter D. Baird ◽  
Hak-Fun Chow ◽  
L.E. Fellows ◽  
G.W.J. Fleet ◽  
...  
Keyword(s):  
Amino Acid ◽  
Carboxylic Acid ◽  
Protein Amino Acid ◽  
X Ray
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