New molecular and field evidences for the implication of mycotoxins but not aristolochic acid in human nephropathy and urinary tract tumor

2007 ◽  
Vol 51 (9) ◽  
pp. 1131-1146 ◽  
Author(s):  
Annie Pfohl-Leszkowicz ◽  
Mariana Tozlovanu ◽  
Richard Manderville ◽  
Maja Peraica ◽  
Marcel Castegnaro ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Aristolochic Acid ◽  
Human Nephropathy

1164 TP53 Mutational Signature of Aristolochic Acid in Carcinomas of the Upper Urinary Tract

2012 ◽  
Vol 48 ◽  
pp. S280
Author(s):  
N. Slade ◽  
M. Moriya ◽  
B. Brdar ◽  
B. Jelakovic ◽  
Z. Medverec ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Aristolochic Acid ◽  
Upper Urinary Tract ◽  
Mutational Signature

scholarly journals Aristolochic acid-associated urinary tract cancers: an updated meta-analysis of risk and oncologic outcomes after surgery and systematic review of molecular alterations observed in human studies

2021 ◽  
Vol 12 ◽  
pp. 204209862199772
Author(s):  
Yu-Chan Kang ◽  
Ming-Hong Chen ◽  
Chung-Ying Lin ◽  
Chih-Yun Lin ◽  
Yen-Ta Chen
Keyword(s):  
Systematic Review ◽  
Urinary Tract ◽  
Aristolochic Acid ◽  
Meta Analysis ◽  
Oncologic Outcomes ◽  
Driver Genes ◽  
Tissue Samples ◽  
Molecular Changes ◽  
Molecular Alterations ◽  
Increased Risk

Background: The risk of primary aristolochic acid (AA)-associated urothelial carcinoma (AA-UC) has been summarized by a 2013-published meta-analysis. Given that additional evidence has been continuously reported by original studies, an updated meta-analysis is needed. Meanwhile, to complete the whole picture, a systematic review of molecular alterations observed in AA-urinary tract cancers (AA-UTC) was also performed. Methods: We searched PubMed, Embase and four Chinese databases up to October 2020. Observational studies comparing risk or oncologic outcomes of UTC between patients with and without AA exposure were eligible for systematic review and meta-analysis. Studies investigating molecular alterations in AA-UTC using human tissue samples were eligible for systematic review. Results: In total, 38 and 20 studies were included in the systematic review and meta-analysis, respectively. Exposure to AA led to an overall increased risks of primary UTC [UC and renal cell carcinoma (RCC)] (OR 6.085, 95% CI 3.045–12.160) and postoperatively recurrent UC (RR 1.831, 95% CI 1.528–2.194). Subgroup analysis of postoperative primary AA-upper tract UC (AA-UTUC) showed increased risks of bladder recurrence (adjusted RR 1.949, 95% CI 1.462–2.597) and contralateral UTUC recurrence (crude RR 3.760, 95% CI 2.225–6.353), worse overall survival (adjusted HR 2.025, 95% CI 1.432–2.865) and worse disease-specific survival (adjusted HR 3.061, 95% CI 1.190–7.872), but no effect on cancer-specific survival (adjusted HR 0.772, 95% CI 0.269–2.215). High mutation load with AA mutational signature presenting largely in the putative driver genes was observed in AA-UTUC. In contrast, AA mutational signature is rarely found in the mutated RCC driver genes and the mutation load in AA-RCC is low. Therefore, AA has different roles in the genesis of UTUC and RCC. Conclusions: Implementing effective strategies to completely protect people from exposure to AA is urgently needed. Additionally, more effort should be made in identifying the precise carcinogenic mechanisms of AA to determine the future treatment strategies. Plain language summary Risk, recurrence and survival outcomes after surgery and molecular changes possibly involved in the genesis of aristolochic acid-associated urinary tract cancers Background: The association between aristolochic acid (AA) and primary urothelial carcinoma (UC) has been summarized by a 2013-published meta-analysis. Given that additional evidence has been reported in the past 7 years, an updated meta-analysis is needed. Meanwhile, to complete the whole picture, a systematic review of molecular changes possibly involved in AA-mediated urinary tract carcinogenesis was also performed. Methods: We searched PubMed, Embase and four Chinese databases for human studies up to October 2020. Studies comparing the risk of urinary tract cancer (UTC) between patients with and without AA exposure and studies investigating the molecular changes in AA-associated UTC (AA-UTC) using human tissue samples were eligible for inclusion. Thirty-eight studies were finally included. Results: The results showed that exposure to AA was associated with a 6-fold increased risk of primary UTC (UC and renal cell carcinoma, RCC) and a 1.8-fold increased risk of postoperatively recurrent UC. After studies reporting primary AA-upper tract UC (AA-UTUC) were analyzed, a 1.9-fold increased risk of bladder recurrence and a 3.8-fold increased risk of contralateral UTUC recurrence was observed. Additionally, exposure to AA worsened the postoperative survival of patients with UTUC by a 2-fold increased risk of overall death and a 3-fold increased risk of death from other diseases and recurrences. However, there was no effect on death due to cancer. Lastly, AA seemed to play different roles in the etiology of UTUC and RCC based on the observations of different mutation loads and different distributions of AA-induced mutations in AA-UTUC and AA-RCC samples. Conclusions: Implementing effective strategies to completely protect people from exposure to AA is urgently needed. Moreover, more effort should be made in identifying the precise carcinogenic mechanisms of AA-UTC to determine the future treatment strategies.

scholarly journals Additive effects of arsenic and aristolochic acid in chemical carcinogenesis of upper urinary tract urothelium

2020 ◽  
pp. cebp.1090.2020
Author(s):  
Chung-Hsin Chen ◽  
Arthur P Grollman ◽  
Chao-Yuan Huang ◽  
Chia-Tung Shun ◽  
Viktoriya S Sidorenko ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Aristolochic Acid ◽  
Chemical Carcinogenesis ◽  
Upper Urinary Tract ◽  
Additive Effects

scholarly journals Risk of urinary tract carcinoma in aristolochic acid nephropathy

2011 ◽  
Vol 27 (1) ◽  
pp. 456-456
Author(s):  
A. A. Pozdzik ◽  
T. Baudoux ◽  
T. Roumeguere ◽  
J.-L. Vanherweghem ◽  
J. L. Nortier
Keyword(s):  
Urinary Tract ◽  
Aristolochic Acid ◽  
Aristolochic Acid Nephropathy
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