scholarly journals Stochastic generation and suppression of early afterdepolarizations in a three‐dimensional model of cardiac action potential

2021 ◽  
Author(s):  
Evdokiia Slepukhina ◽  
Irina Bashkirtseva ◽  
Philipp Kügler ◽  
Lev Ryashko
Keyword(s):  
Action Potential ◽  
Three Dimensional ◽  
Cardiac Action Potential ◽  
Dimensional Model ◽  
Three Dimensional Model ◽  
Early Afterdepolarizations ◽  
Stochastic Generation ◽  
Cardiac Action

scholarly journals A protocol combining current- and voltage-clamp provides a novel and useful three-dimensional representation of cardiac action potential

2014 ◽  
Vol 87 (1) ◽  
Author(s):  
Massimiliano Zaniboni ◽  
Francesca Cacciani
Keyword(s):  
Action Potential ◽  
Current Source ◽  
Three Dimensional ◽  
Membrane Conductance ◽  
Ventricular Repolarization ◽  
Cardiac Action Potential ◽  
Dimensional Representation ◽  
Cardiac Action ◽  
Three Dimensional Representation

A compact three-dimensional representation of cardiac action potential (AP) properties in terms of current source is presented here. The experimental protocol used to obtain such representation is based on the measure of instantaneous current-voltage relationships during the course of the AP. The procedure, which combines current- and voltage-clamps on patch clamped cardiac myocytes, has been previously applied to real cells, and then extended to computer simulations with cellular ventricular AP models. The three-dimensional AP representation allows to easily estimate membrane resistance during repolarization, a key factor for the modulation of ventricular repolarization. It also shows that, during late ventricular repolarization, membrane conductance becomes negative, <em>i.e.</em> repolarization is auto-regenerative. The novel AP representation is therefore a useful tool for both in vivo and in silico cardiac cellular electrophysiological investigations.

scholarly journals An Optical Mapping of Cardiac Action Potential on the Three-Dimensional Surface Model of a Heart

2004 ◽  
Vol 16 (Supplement) ◽  
pp. 221-222
Author(s):  
Shiho Nashimoto ◽  
Yuhei Takata ◽  
Takahiro Yamaguchi ◽  
Tatsuhiko Arafune ◽  
Etsuko Kobayashi ◽  
...  
Keyword(s):  
Action Potential ◽  
Optical Mapping ◽  
Three Dimensional ◽  
Cardiac Action Potential ◽  
Surface Model ◽  
Cardiac Action ◽  
Dimensional Surface

scholarly journals Cisapride-induced prolongation of cardiac action potential and early afterdepolarizations in rabbit Purkinje fibres

1996 ◽  
Vol 117 (7) ◽  
pp. 1377-1379 ◽  
Author(s):  
François L. Puisieux ◽  
Monique M. Adamantidis ◽  
Bérengére M. Dumotier ◽  
Bernard A. Dupuis
Keyword(s):  
Action Potential ◽  
Cardiac Action Potential ◽  
Early Afterdepolarizations ◽  
Purkinje Fibres ◽  
Cardiac Action

Three-Dimensional Model for Virtual Surgical Simulation, during Complex Skull Base Surgery and Aneurysm Surgery

Skull Base ◽  
2008 ◽  
Vol 18 (S 01) ◽  
Author(s):  
Akio Morita ◽  
Toshikazu Kimura ◽  
Shigeo Sora ◽  
Kengo Nishimura ◽  
Hisayuki Sugiyama ◽  
...  
Keyword(s):  
Skull Base ◽  
Surgical Simulation ◽  
Skull Base Surgery ◽  
Three Dimensional ◽  
Aneurysm Surgery ◽  
Dimensional Model ◽  
Three Dimensional Model
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