scholarly journals On the potential in non‐Gaussian chain polymer models

2019 ◽  
Vol 42 (18) ◽  
pp. 7452-7460
Author(s):  
Wolfgang Bock ◽  
José Luís Silva ◽  
Ludwig Streit
Keyword(s):  
Chain Polymer ◽  
Gaussian Chain ◽  
Polymer Models ◽  
Non Gaussian

Single-Chain Polymer Models Incorporating the Effects of Side Groups: An Approach to General Polymer Models

2019 ◽  
Vol 52 (19) ◽  
pp. 7324-7330 ◽  
Author(s):  
Wanhao Cai ◽  
Song Lu ◽  
Junhao Wei ◽  
Shuxun Cui
Keyword(s):  
Single Chain ◽  
Chain Polymer ◽  
Polymer Models

A Consideration of the Yamamoto Network Theory with Non‐Gaussian Chain Segments

1987 ◽  
Vol 31 (5) ◽  
pp. 371-384 ◽  
Author(s):  
E. P. Vrahopoulou ◽  
A. J. McHugh
Keyword(s):  
Network Theory ◽  
Gaussian Chain ◽  
Non Gaussian

scholarly journals Molecular aspects of multivalent engagement between Syk and FcεRIγ

2018 ◽  
Author(s):  
Timothy Travers ◽  
William Kanagy ◽  
Elton Jhamba ◽  
Byron Goldstein ◽  
Diane S. Lidke ◽  
...  
Keyword(s):  
Computational Models ◽  
Md Simulations ◽  
Immune Recognition ◽  
Chain Polymer ◽  
Sh2 Domains ◽  
Model Predictions ◽  
Polymer Models ◽  
Molecular Aspects ◽  
Binding Orientations ◽  
The Impact

ABSTRACTSyk/Zap70 family kinases are essential for signaling via multichain immune-recognition receptors such as the tetrameric (αβγ2) FcεRI The simplest model assumes that Syk activation occurs through cis binding of its tandem SH2 domains to dual phosphotyrosines within immunoreceptor tyrosine-based activation motifs of individual γ chains. In this model, Syk activity is modulated by phosphorylation occurring between adjacent Syk molecules docked on γ homodimers and by Lyn molecules bound to FcεRIβ. However, the mechanistic details of Syk docking on γ homodimers are not fully resolved, particularly the possibility of trans binding orientations and the impact of Y130 autophosphorylation within Syk interdomain A. Analytical modeling shows that multivalent interactions lead to increased WT Syk cis-oriented binding by three orders of magnitude. Molecular dynamics (MD) simulations show increased inter-SH2 flexibility in a Y130E phosphomimetic form of Syk, associated with reduced overall helicity of interdomain A. Hybrid MD/worm-like chain polymer models show that the Y130E substitution reduces cis binding of Syk. We report computational models and estimates of relative binding for all possible cis and trans 2:2 Syk:FcεRIγ complexes. Calcium imaging experiments confirm model predictions that cis binding of WT Syk is strongly preferred for efficient signaling, while trans conformations trigger weak but measurable responses.

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