Dynamics of an HIV‐1 virus model with both virus‐to‐cell and cell‐to‐cell transmissions, general incidence rate, intracellular delay, and CTL immune responses

2019 ◽  
Vol 42 (18) ◽  
pp. 6385-6406 ◽  
Author(s):  
Hong Yan ◽  
Yanyu Xiao ◽  
Qian Yan ◽  
Xianning Liu
Keyword(s):  
Immune Responses ◽  
Incidence Rate ◽  
Intracellular Delay ◽  
General Incidence Rate ◽  
Virus Model ◽  
Hiv 1

scholarly journals Global Stability of an HIV-1 Infection Model with General Incidence Rate and Distributed Delays

2014 ◽  
Vol 2014 ◽  
pp. 1-10
Author(s):  
Abdoul Samba Ndongo ◽  
Hamad Talibi Alaoui
Keyword(s):  
Incidence Rate ◽  
Viral Entry ◽  
Disease Transmission ◽  
Transmission Function ◽  
Infection Model ◽  
Global Dynamics ◽  
General Incidence Rate ◽  
Delay Differential ◽  
Hiv 1 ◽  
Intracellular Delays

In this work an HIV-1 infection model with nonlinear incidence rate and distributed intracellular delays and with humoral immunity is investigated. The disease transmission function is assumed to be governed by general incidence rate f(T,V)V. The intracellular delays describe the time between viral entry into a target cell and the production of new virus particles and the time between infection of a cell and the emission of viral particle. Lyapunov functionals are constructed and LaSalle invariant principle for delay differential equation is used to establish the global asymptotic stability of the infection-free equilibrium, infected equilibrium without B cells response, and infected equilibrium with B cells response. The results obtained show that the global dynamics of the system depend on both the properties of the general incidence function and the value of certain threshold parameters R0 and R1 which depends on the delays.

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