Predicting Novel Antitumor Agents: 3D-Pharmacophore Mapping of β-N -biaryl Ether Sulfonamide-Based Hydroxamates as Potentially MMP-2 Inhibitors

2014 ◽  
Vol 33 (9) ◽  
pp. 573-587 ◽  
Author(s):  
Kely Medeiros Turra ◽  
Diogo Pineda Rivelli ◽  
Silvia Berlanga de Moraes Barros ◽  
Kerly Fernanda Mesquita Pasqualoto
Keyword(s):  
Antitumor Agents ◽  
Pharmacophore Mapping ◽  
3D Pharmacophore ◽  
Biaryl Ether

3D-Pharmacophore mapping of thymidine-based inhibitors of TMPK as potential antituberculosis agents

2010 ◽  
Vol 24 (2) ◽  
pp. 157-172 ◽  
Author(s):  
Carolina Horta Andrade ◽  
Kerly F. M. Pasqualoto ◽  
Elizabeth I. Ferreira ◽  
Anton J. Hopfinger
Keyword(s):  
Pharmacophore Mapping ◽  
3D Pharmacophore

Rational Design and 3D-Pharmacophore Mapping of 5′-Thiourea-Substituted α-Thymidine Analogues as Mycobacterial TMPK Inhibitors

2009 ◽  
Vol 49 (4) ◽  
pp. 1070-1078 ◽  
Author(s):  
Carolina H. Andrade ◽  
Kerly F. M. Pasqualoto ◽  
Elizabeth I. Ferreira ◽  
Anton J. Hopfinger
Keyword(s):  
Rational Design ◽  
Pharmacophore Mapping ◽  
3D Pharmacophore

scholarly journals Molecular modeling and analysis of the 3D pharmacophore structure of the selective PI3K-α inhibitors as antitumor agents

2018 ◽  
Vol 68 (4) ◽  
pp. 860-873
Author(s):  
Milan Jovanović ◽  
Katarina Nikolić ◽  
Žarko Gagić ◽  
Danica Agbaba
Keyword(s):  
Molecular Modeling ◽  
Antitumor Agents ◽  
Modeling And Analysis ◽  
3D Pharmacophore

Vitamin D as potential therapeutic anticancer agent

2018 ◽  
pp. 1-3
Keyword(s):  
Vitamin D ◽  
Anticancer Activity ◽  
Anticancer Agent ◽  
Antitumor Agents ◽  
Metastatic Potential ◽  
Anticancer Properties ◽  
Chemotherapy Agents

The role of vitamin D is implicated in carcinogenesis through numerous biological processes like induction of apoptosis, modulation of immune system inhibition of inflammation and cell proliferation and promotion of cell differentiation. Its use as additional adjuvant drug with cancer treatment may be novel combination for improved outcome of different cancers. Numerous preclinical, epidemiological and clinical studies support the role of vitamin D as an anticancer agent. Anticancer properties of vitamin D have been studied widely (both in vivo and in vitro) among various cancers and found to have promising results. There are considerable data that indicate synergistic potential of calcitriol and antitumor agents. Possible mechanisms for modulatory anticancer activity of vitamin D include its antiproliferative, prodifferentiating, and anti-angiogenic and apoptic properties. Calcitriol reduces invasiveness and metastatic potential of many cancer cells by inhibiting angiogenesis and regulating expression of the key molecules involved in invasion and metastasis. Anticancer activity of vitamin D is synergistic or additive with the antineoplastic actions of several drugs including cytotoxic chemotherapy agents like paclitaxel, docetaxel, platinum base compounds and mitoxantrone. Benefits of addition of vitamin D should be weighed against the risk of its toxicity.

Oxazole: A Promising Building Block for the Development of Potent Antitumor Agents

2016 ◽  
Vol 16 (30) ◽  
pp. 3582-3589 ◽  
Author(s):  
Hua Zhou ◽  
Jiang-Qun Cheng ◽  
Zhi-Sen Wang ◽  
Fei-Hu Chen ◽  
Xin-Hua Liu
Keyword(s):  
Building Block ◽  
Antitumor Agents
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