scholarly journals Drug-Like ProteinProtein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology

2014 ◽  
Vol 33 (6-7) ◽  
pp. 414-437 ◽  
Author(s):  
Bruno O. Villoutreix ◽  
Melaine A. Kuenemann ◽  
Jean-Luc Poyet ◽  
Heriberto Bruzzoni-Giovanelli ◽  
Céline Labbé ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Protein Interaction ◽  
Chemical Biology ◽  
Protein Protein Interaction ◽  
Challenges And Opportunities

Protein-Protein Interaction (PPI) Network: Recent Advances in Drug Discovery

2017 ◽  
Vol 18 (1) ◽  
pp. 5-10 ◽  
Author(s):  
Alexiou Athanasios ◽  
Vairaktarakis Charalampos ◽  
Tsiamis Vasileios ◽  
Ghulam Ashraf
Keyword(s):  
Drug Discovery ◽  
Protein Interaction ◽  
Ppi Network ◽  
Protein Protein Interaction ◽  
Recent Advances

scholarly journals Developing Inhibitors of the p47phox–p22phox Protein–Protein Interaction by Fragment-Based Drug Discovery

2020 ◽  
Vol 63 (3) ◽  
pp. 1156-1177 ◽  
Author(s):  
Sara Marie Øie Solbak ◽  
Jie Zang ◽  
Dilip Narayanan ◽  
Lars Jakobsen Høj ◽  
Saskia Bucciarelli ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Protein Interaction ◽  
Protein Protein Interaction ◽  
Fragment Based Drug Discovery

scholarly journals Optimization of Protein–Protein Interaction Measurements for Drug Discovery Using AFM Force Spectroscopy

2019 ◽  
Vol 18 ◽  
pp. 509-517
Author(s):  
Yongliang Yang ◽  
Lixin Dong ◽  
Ruiguo Yang ◽  
Ning Xi ◽  
Bixi Zeng ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Protein Interaction ◽  
Force Spectroscopy ◽  
Protein Protein Interaction

scholarly journals Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

2016 ◽  
Vol 15 (8) ◽  
pp. 533-550 ◽  
Author(s):  
Duncan E. Scott ◽  
Andrew R. Bayly ◽  
Chris Abell ◽  
John Skidmore
Keyword(s):  
Drug Discovery ◽  
Small Molecules ◽  
Protein Interaction ◽  
Protein Protein Interaction

scholarly journals Identification of key candidate genes and molecular pathways in white fat browning: an anti-obesity drug discovery based on computational biology

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Yuyan Pan ◽  
Jiaqi Liu ◽  
Fazhi Qi
Keyword(s):  
Adipose Tissue ◽  
Drug Discovery ◽  
Text Mining ◽  
Protein Interaction ◽  
Metabolic Diseases ◽  
Interaction Analysis ◽  
Brown Fat ◽  
Molecular Pathways ◽  
Protein Protein Interaction ◽  
White Fat

Abstract Background Obesity—with its increased risk of obesity-associated metabolic diseases—has become one of the greatest public health epidemics of the twenty-first century in affluent countries. To date, there are no ideal drugs for treating obesity. Studies have shown that activation of brown adipose tissue (BAT) can promote energy consumption and inhibit obesity, which makes browning of white adipose tissue (WAT) a potential therapeutic target for obesity. Our objective was to identify genes and molecular pathways associated with WAT and the activation of BAT to WAT browning, by using publicly available data and computational tools; this knowledge might help in targeting relevant signaling pathways for treating obesity and other related metabolic diseases. Results In this study, we used text mining to find out genes related to brown fat and white fat browning. Combined with biological process and pathway analysis in GeneCodis and protein-protein interaction analysis by using STRING and Cytoscape, a list of high priority target genes was developed. The Human Protein Atlas was used to analyze protein expression. Candidate drugs were derived on the basis of the drug-gene interaction analysis of the final genes. Our study identified 18 genes representing 6 different pathways, targetable by a total of 33 drugs as possible drug treatments. The final list included 18 peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists, 4 beta 3 adrenoceptor (β3-AR) agonists, 1 insulin sensitizer, 3 insulins, 6 lipase clearing factor stimulants and other drugs. Conclusions Drug discovery using in silico text mining, pathway, and protein-protein interaction analysis tools may be a method of exploring drugs targeting the activation of brown fat or white fat browning, which provides a basis for the development of novel targeted therapies as potential treatments for obesity and related metabolic diseases.

Target validation and drug discovery using genomic and protein–protein interaction technologies

2002 ◽  
Vol 6 (4) ◽  
pp. 517-531 ◽  
Author(s):  
Renuka C Pillutla ◽  
Paul B Fisher ◽  
Arthur J Blume ◽  
Neil I Goldstein
Keyword(s):  
Drug Discovery ◽  
Protein Interaction ◽  
Target Validation ◽  
Protein Protein Interaction

Novel Technology for Protein-Protein Interaction-based Targeted Drug Discovery

2011 ◽  
Vol 2 (Supplement A) ◽  
pp. A61-A65 ◽  
Author(s):  
Jung Me Hwang ◽  
Kyung-Bok Lee ◽  
Jong-Soon Choi ◽  
Jaerang Rho ◽  
Gun-Hwa Kim ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Protein Interaction ◽  
Protein Protein Interaction ◽  
Novel Technology ◽  
Targeted Drug ◽  
Targeted Drug Discovery
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