Prediction of Bovine Serum Albumin-Water Partition Coefficients of a Wide Variety of Neutral Organic Compounds by Means of Support Vector Machine

2012 ◽  
Vol 31 (11-12) ◽  
pp. 867-878 ◽  
Author(s):  
Hassan Golmohammadi ◽  
Zahra Dashtbozorgi ◽  
William E. Acree
Keyword(s):  
Support Vector Machine ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Organic Compounds ◽  
Bovine Serum ◽  
Partition Coefficients ◽  
Support Vector ◽  
Neutral Organic Compounds

Partition coefficients of four perfluoroalkyl acid alternatives between bovine serum albumin (BSA) and water in comparison to ten classical perfluoroalkyl acids

2019 ◽  
Vol 21 (11) ◽  
pp. 1852-1863 ◽  
Author(s):  
Flora Allendorf ◽  
Urs Berger ◽  
Kai-Uwe Goss ◽  
Nadin Ulrich
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Partition Coefficients ◽  
Perfluoroalkyl Acids ◽  
Long Chain ◽  
Perfluoroalkyl Acid

Alternatives to long-chain PFAAs sorb similarly strongly to serum albumin as the classical PFAAs.

scholarly journals The thermodynamics of interaction between Sephadex and penetrating solutes

1970 ◽  
Vol 116 (2) ◽  
pp. 171-175 ◽  
Author(s):  
A. G. Ogston ◽  
Panee Silpananta
Keyword(s):  
Phase Separation ◽  
Polyethylene Glycol ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Partition Coefficients ◽  
Virial Coefficients

1. We have measured the partition coefficients of bovine serum albumin with Sephadex grades G-100, G-150 and G-200, and of a dextran ([unk]n 19700) and a polyethylene glycol ([unk]n 8000) with Sephadex G-200. We have also measured the effects of these solutes on the inner volumes of the grades of Sephadex. 2. The results can be described with fair consistency by means of a simple thermodynamic treatment that makes use of the virial coefficients of Sephadex and of the solute, and of a coefficient that expresses their interaction. This coefficient is related to the ‘exclusion volume’ of Sephadex for the solutes. 3. The Sephadex G-200–polyethylene glycol system shows anomalies of behaviour that are ascribed to the occurrence of ‘incompatible’ phase separation within the Sephadex beads.

scholarly journals 3D-QSAR predictions for bovine serum albumin–water partition coefficients of organic anions using quantum mechanically based descriptors

2017 ◽  
Vol 19 (3) ◽  
pp. 261-269 ◽  
Author(s):  
Lukas Linden ◽  
Kai-Uwe Goss ◽  
Satoshi Endo
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Partition Coefficients ◽  
3D Qsar ◽  
Qsar Model ◽  
Organic Anions ◽  
Steric Effects

The 3D-QSAR model predicts the bovine serum albumin–water partition coefficients for neutral and anionic chemicals influenced by steric effects.

Improvement of an artificial test substrate technique for evaluation of em immunocytochemical labeling

1987 ◽  
Vol 45 ◽  
pp. 762-763
Author(s):  
G. D. Gagne ◽  
M. F. Miller
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Artificial Substrate ◽  
Chemical Fixation ◽  
As If

We recently described an artificial substrate system which could be used to optimize labeling parameters in EM immunocytochemistry (ICC). The system utilizes blocks of glutaraldehyde polymerized bovine serum albumin (BSA) into which an antigen is incorporated by a soaking procedure. The resulting antigen impregnated blocks can then be fixed and embedded as if they are pieces of tissue and the effects of fixation, embedding and other parameters on the ability of incorporated antigen to be immunocyto-chemically labeled can then be assessed. In developing this system further, we discovered that the BSA substrate can also be dried and then sectioned for immunolabeling with or without prior chemical fixation and without exposing the antigen to embedding reagents. The effects of fixation and embedding protocols can thus be evaluated separately.

Stability of Prostacyclin in Human Plasma and Whole Blood: Studies on the Protective Effect of Albumin

1981 ◽  
Vol 46 (03) ◽  
pp. 645-647 ◽  
Author(s):  
M A Orchard ◽  
C Robinson
Keyword(s):  
Platelet Aggregation ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Protective Effect ◽  
Whole Blood ◽  
Bovine Serum ◽  
Fatty Acid Content ◽  
Krebs Solution ◽  
Antiaggregatory Activity ◽  
Free Plasma

SummaryThe biological half-life of prostacyclin in Krebs solution, human cell-free plasma or whole blood was measured by bracket assay on ADP-induced platelet aggregation. At 37°C, pH 7.4, plasma and blood reduced the rate of loss of antiaggregatory activity compared with Krebs solution. The protective effect of plasma was greater than that of whole blood. This effect could be partially mimicked by the addition of human or bovine serum albumin to the Krebs solution. The stabilisation afforded by human serum albumin was dependent on the fatty acid content of the albumin, although this was less important for bovine serum albumin.

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