Efficacy of sliced nerves of different thickness in a biodegradable nerve conduit to promote Schwann cell migration and axonal growth: An experimental study in the rat model

Microsurgery ◽  
2021 ◽  
Author(s):  
Yu Sueyoshi ◽  
Noritaka Isogai ◽  
Yoshiaki Nagumo ◽  
Yuta Onodera ◽  
Takeshi Teramura ◽  
...  
Keyword(s):  
Experimental Study ◽  
Cell Migration ◽  
Schwann Cell ◽  
Rat Model ◽  
Axonal Growth ◽  
Nerve Conduit ◽  
Schwann Cell Migration ◽  
Different Thickness

Functionalization of Electrospun Poly(ε-Caprolactone) Fibers with the Extracellular Matrix-Derived Peptide GRGDS Improves Guidance of Schwann Cell Migration and Axonal Growth

2011 ◽  
Vol 17 (3-4) ◽  
pp. 475-486 ◽  
Author(s):  
Julia Bockelmann ◽  
Kristina Klinkhammer ◽  
Alexander von Holst ◽  
Nadine Seiler ◽  
Andreas Faissner ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Migration ◽  
Schwann Cell ◽  
Axonal Growth ◽  
Schwann Cell Migration

scholarly journals Lysophosphatidic acid (LPA) and its receptor, LPA1, influence embryonic schwann cell migration, myelination, and cell-to-axon segregation

Glia ◽  
2013 ◽  
Vol 61 (12) ◽  
pp. 2009-2022 ◽  
Author(s):  
Brigitte Anliker ◽  
Ji Woong Choi ◽  
Mu-En Lin ◽  
Shannon E. Gardell ◽  
Richard R. Rivera ◽  
...  
Keyword(s):  
Cell Migration ◽  
Schwann Cell ◽  
Lysophosphatidic Acid ◽  
Schwann Cell Migration

scholarly journals ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration

2008 ◽  
Vol 181 (2) ◽  
pp. 351-365 ◽  
Author(s):  
Junji Yamauchi ◽  
Yuki Miyamoto ◽  
Jonah R. Chan ◽  
Akito Tanoue
Keyword(s):  
Cell Migration ◽  
Schwann Cell ◽  
Rho Gtpase ◽  
Morphological Changes ◽  
Nucleotide Exchange ◽  
Exchange Factor ◽  
Guanine Nucleotide Exchange ◽  
Nucleotide Exchange Factor ◽  
Schwann Cell Migration ◽  
Subsequent Activation

The cellular events that precede myelination in the peripheral nervous system require rapid and dynamic morphological changes in the Schwann cell. These events are thought to be mainly controlled by axonal signals. But how signals on the axons are coordinately organized and transduced to promote proliferation, migration, radial sorting, and myelination is unknown. We describe that the axonal signal neuregulin-1 (NRG1) controls Schwann cell migration via activation of the atypical Dock180-related guanine nucleotide exchange factor (GEF) Dock7 and subsequent activation of the Rho guanine triphosphatases (GTPases) Rac1 and Cdc42 and the downstream c-Jun N-terminal kinase. We show that the NRG1 receptor ErbB2 directly binds and activates Dock7 by phosphorylating Tyr-1118. Dock7 knockdown, or expression of Dock7 harboring the Tyr-1118–to–Phe mutation in Schwann cells, attenuates the effects of NRG1. Thus, Dock7 functions as an intracellular substrate for ErbB2 to promote Schwann cell migration. This provides an unanticipated mechanism through which ligand-dependent tyrosine phosphorylation can trigger the activation of Rho GTPase-GEFs of the Dock180 family.

Promoting Neurite Growth and Schwann Cell Migration by the Harnessing Decellularized Nerve Matrix onto Nanofibrous Guidance

2019 ◽  
Vol 11 (19) ◽  
pp. 17167-17176 ◽  
Author(s):  
Shihao Chen ◽  
Zhaoyi Du ◽  
Jianlong Zou ◽  
Shuai Qiu ◽  
Zilong Rao ◽  
...  
Keyword(s):  
Cell Migration ◽  
Schwann Cell ◽  
Neurite Growth ◽  
Schwann Cell Migration
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