C1 esterase inhibitor ameliorates ischemia reperfusion injury in a swine musculocutaneous flap model

Microsurgery ◽  
2016 ◽  
Vol 37 (2) ◽  
pp. 142-147 ◽  
Author(s):  
C.Anton Fries ◽  
Carole Y. Villamaria ◽  
Jerry R. Spencer ◽  
Todd E. Rasmussen ◽  
Michael R. Davis
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Musculocutaneous Flap ◽  
C1 Esterase Inhibitor ◽  
Esterase Inhibitor

scholarly journals C1 Esterase Inhibitor Reduces Lower Extremity Ischemia/Reperfusion Injury and Associated Lung Damage

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72059 ◽  
Author(s):  
Claudia Duehrkop ◽  
Yara Banz ◽  
Rolf Spirig ◽  
Sylvia Miescher ◽  
Marc W. Nolte ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Lung Damage ◽  
C1 Esterase Inhibitor ◽  
Lower Extremity Ischemia ◽  
Esterase Inhibitor ◽  
Extremity Ischemia

Effects of C1 esterase inhibitor on attenuation of ischemia/reperfusion injury in a rat hind limb model

Immunobiology ◽  
2012 ◽  
Vol 217 (11) ◽  
pp. 1165-1166
Author(s):  
Claudia Dührkop-Sisewitsch ◽  
Yara Banz Wälti ◽  
Rolf Spirig ◽  
Sylvia Miescher ◽  
Marc W. Nolte ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Hind Limb ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
C1 Esterase Inhibitor ◽  
Esterase Inhibitor

scholarly journals Three-Year Outcomes of a Randomized, Double-Blind, Placebo-Controlled Study Assessing Safety and Efficacy of C1 Esterase Inhibitor for Prevention of Delayed Graft Function in Deceased Donor Kidney Transplant Recipients

2019 ◽  
Vol 15 (1) ◽  
pp. 109-116 ◽  
Author(s):  
Edmund Huang ◽  
Ashley Vo ◽  
Jua Choi ◽  
Noriko Ammerman ◽  
Kathlyn Lim ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Graft Failure ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Controlled Trial ◽  
Graft Function ◽  
Deceased Donor ◽  
Delayed Graft Function ◽  
C1 Esterase Inhibitor ◽  
Esterase Inhibitor

Background and objectivesDelayed graft function is related to ischemia-reperfusion injury and may be complement dependent. We previously reported from a randomized, placebo-controlled trial that treatment with C1 esterase inhibitor was associated with a shorter duration of delayed graft function and higher eGFR at 1 year. Here, we report longer-term outcomes from this trial.Design, setting, participants, & measurementsThis is a post hoc analysis of a phase 1/2, randomized, controlled trial enrolling 70 recipients of deceased donor kidney transplants at risk for delayed graft function (NCT02134314). Subjects were randomized to receive C1 esterase inhibitor 50 U/kg (n=35) or placebo (n=35) intraoperatively and at 24 hours. The cumulative incidence functions method was used to compare graft failure and death over 3.5 years. eGFR slopes were compared using a linear mixed effects model.ResultsThree deaths occurred among C1 esterase inhibitor–treated patients compared with none receiving placebo. Seven graft failures developed in the placebo group compared with one among C1 esterase inhibitor–treated recipients; the cumulative incidence of graft failure was lower over 3.5 years among C1 esterase inhibitor–treated recipients compared with placebo (P=0.03). Although no difference in eGFR slopes was observed between groups (P for group-time interaction =0.12), eGFR declined in placebo-treated recipients (−4 ml/min per 1.73 m2 per year; 95% confidence interval, −8 to −0.1) but was stable in C1 esterase inhibitor–treated patients (eGFR slope: 0.5 ml/min per 1.73 m2 per year; 95% confidence interval, −4 to 5). At 3.5 years, eGFR was 56 ml/min per 1.73 m2 (95% confidence interval, 42 to 70) in the C1 esterase inhibitor group versus 35 ml/min per 1.73 m2 (95% confidence interval, 21 to 48) in the placebo group, with an estimated mean eGFR difference of 21 ml/min per 1.73 m2 (95% confidence interval, 2 to 41 ml/min per 1.73 m2).ConclusionsTreatment of patients at risk for ischemia-reperfusion injury and delayed graft function with C1 esterase inhibitor was associated with a lower incidence of graft failure.

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