scholarly journals Knee joint transplantation combined with surgical angiogenesis in rabbits—A new experimental model

Microsurgery ◽  
2011 ◽  
Vol 32 (2) ◽  
pp. 118-127 ◽  
Author(s):  
Thomas Kremer ◽  
Guilherme Giusti ◽  
Patricia F. Friedrich ◽  
Wouter Willems ◽  
Allen T. Bishop ◽  
...  
1998 ◽  
Vol 11 (s1) ◽  
pp. S487-S490 ◽  
Author(s):  
G. O. Hofmann ◽  
M. H. Kirschner ◽  
L. Brauns ◽  
F. D. Wagner ◽  
W. Land ◽  
...  

2008 ◽  
Vol 16 (4) ◽  
pp. 470-479 ◽  
Author(s):  
C. Boulocher ◽  
M.-E. Duclos ◽  
F. Arnault ◽  
O. Roualdes ◽  
D. Fau ◽  
...  

2013 ◽  
Vol 131 (2) ◽  
pp. 148e-157e ◽  
Author(s):  
Thomas Kremer ◽  
Goetz A. Giessler ◽  
Patricia F. Friedrich ◽  
Wouter F. Willems ◽  
Guilherme Giusti ◽  
...  

2002 ◽  
Vol 11 (2) ◽  
pp. 75-79 ◽  
Author(s):  
Diadelis Remirez ◽  
Ricardo González ◽  
Nelson Merino ◽  
Sandra Rodriguez ◽  
Odelsa Ancheta

The anti-inflammatory effect of microalgae Spirulina was studied in zymosan-induced arthritis in mice. Four days after the intra-articular injection of zymosan (15 mg/ml), Spirulina (100 and 400 mg/kg per-orally) was administered to animals for 8 days. The mice were than killed and β-glucuronidase was measured in the synovial fluid. Each knee joint was totally removed for histopathological studies. Spirulina significantly reduced the levels of β-glucuronidase that had been increased by zymosan. Histopathological and ultrastructural studies showed inhibition of the inflammatory reaction, whereas no destruction of cartilage, well-preserved chondrocytes, and normal rough endoplasmic reticulum and mitochondria were seen. The anti-arthritic effect exerted by Spirulina as shown in this model may be at least partly due to the previously reported anti-inflammatory and antioxidative properties of its constituent, phycocyanin. To our knowledge, this is the first report on the anti-inflammatory effect of Spirulina in an experimental model of arthritis.


1998 ◽  
Vol 11 (0) ◽  
pp. S487-S490 ◽  
Author(s):  
G. O. Hofmann ◽  
M. H. Kirschner ◽  
L. Brauns ◽  
F. D. Wagner ◽  
W. Land ◽  
...  

1997 ◽  
Vol 63 (12) ◽  
pp. 1723-1733 ◽  
Author(s):  
Raphael Rosso ◽  
Dirk Sch??fer ◽  
Renato Fricker ◽  
J??rg Brennwald ◽  
Gernot Jundt ◽  
...  

1996 ◽  
Vol 118 (4) ◽  
pp. 557-564 ◽  
Author(s):  
J. J. Duquette ◽  
P. Grigg ◽  
A. H. Hoffman

A series of experiments was performed to determine the effect of diabetes on the viscoelastic properties of knee joint ligaments. The experimental model was collateral ligaments from spontaneously diabetic, hyperglycemic (BBZDP/Wor) rats, and various controls including nondiabetic littermates, insulin treated diabetic rats, and alloxan treated rats. Material properties were measured using a dynamic, uniaxial loading paradigm. Ligaments were subjected to load controlled, sinusoidal tensile testing, using frequencies from 0.1 to 2.0 Hz. The resulting data were used to determine the storage and loss compliances of the ligaments Storage compliance, which reflects tissue elastic properties, did not differ between groups Loss compliance, which reflects the viscous component of the tissue response, was increased in the hyperglycemic animals. Thus, hyperglycemic diabetes affects tissue mechanical properties through the viscous rather than the elastic component of the response to dynamic loading. Rats treated with alloxan to induce diabetes did not show an increase in loss compliance.


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